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Gene: NELL1 |
Gene summary for NELL1 |
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Gene information | Species | Human | Gene symbol | NELL1 | Gene ID | 4745 |
Gene name | neural EGFL like 1 | |
Gene Alias | IDH3GL | |
Cytomap | 11p15.1 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | B3KXR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4745 | NELL1 | RNA-P18T-P18T-2 | Human | Lung | IAC | 5.73e-08 | 1.55e+00 | 0.1129 |
4745 | NELL1 | RNA-P18T-P18T-4 | Human | Lung | IAC | 2.30e-04 | 1.13e+00 | 0.1024 |
4745 | NELL1 | RNA-P18T-P18T-6 | Human | Lung | IAC | 7.96e-06 | 1.28e+00 | 0.0856 |
4745 | NELL1 | RNA-P18T-P18T-8 | Human | Lung | IAC | 1.76e-10 | 1.86e+00 | 0.1151 |
4745 | NELL1 | RNA-P23T2-P23T2-2 | Human | Lung | MIAC | 3.17e-04 | 9.25e-01 | -0.028 |
4745 | NELL1 | RNA-P23T2-P23T2-4 | Human | Lung | MIAC | 3.47e-02 | 8.50e-01 | -0.0272 |
4745 | NELL1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.03e-03 | 3.65e-01 | -0.2116 |
4745 | NELL1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.54e-17 | 1.43e+00 | -0.0961 |
4745 | NELL1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 2.95e-17 | 1.29e+00 | -0.0876 |
4745 | NELL1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 5.30e-14 | 1.21e+00 | -0.0822 |
4745 | NELL1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.20e-20 | 1.38e+00 | -0.0809 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00421768 | Lung | IAC | regulation of protein catabolic process | 97/2061 | 391/18723 | 6.32e-15 | 1.25e-11 | 97 |
GO:19033628 | Lung | IAC | regulation of cellular protein catabolic process | 63/2061 | 255/18723 | 4.30e-10 | 9.45e-08 | 63 |
GO:00098958 | Lung | IAC | negative regulation of catabolic process | 66/2061 | 320/18723 | 3.26e-07 | 2.48e-05 | 66 |
GO:00313308 | Lung | IAC | negative regulation of cellular catabolic process | 57/2061 | 262/18723 | 3.31e-07 | 2.49e-05 | 57 |
GO:00421778 | Lung | IAC | negative regulation of protein catabolic process | 29/2061 | 121/18723 | 3.88e-05 | 9.51e-04 | 29 |
GO:19033637 | Lung | IAC | negative regulation of cellular protein catabolic process | 18/2061 | 75/18723 | 1.06e-03 | 1.26e-02 | 18 |
GO:004217613 | Lung | AIS | regulation of protein catabolic process | 92/1849 | 391/18723 | 1.34e-15 | 3.91e-12 | 92 |
GO:190336213 | Lung | AIS | regulation of cellular protein catabolic process | 62/1849 | 255/18723 | 1.37e-11 | 6.13e-09 | 62 |
GO:003133013 | Lung | AIS | negative regulation of cellular catabolic process | 50/1849 | 262/18723 | 3.94e-06 | 2.05e-04 | 50 |
GO:000989513 | Lung | AIS | negative regulation of catabolic process | 55/1849 | 320/18723 | 3.22e-05 | 1.01e-03 | 55 |
GO:004217713 | Lung | AIS | negative regulation of protein catabolic process | 26/1849 | 121/18723 | 1.09e-04 | 2.57e-03 | 26 |
GO:190336312 | Lung | AIS | negative regulation of cellular protein catabolic process | 18/1849 | 75/18723 | 2.89e-04 | 5.40e-03 | 18 |
GO:004217633 | Lung | MIAC | regulation of protein catabolic process | 47/967 | 391/18723 | 6.27e-08 | 2.15e-05 | 47 |
GO:190336233 | Lung | MIAC | regulation of cellular protein catabolic process | 34/967 | 255/18723 | 3.83e-07 | 6.52e-05 | 34 |
GO:003133033 | Lung | MIAC | negative regulation of cellular catabolic process | 28/967 | 262/18723 | 2.23e-04 | 7.67e-03 | 28 |
GO:190336322 | Lung | MIAC | negative regulation of cellular protein catabolic process | 11/967 | 75/18723 | 1.56e-03 | 2.65e-02 | 11 |
GO:000989523 | Lung | MIAC | negative regulation of catabolic process | 29/967 | 320/18723 | 2.42e-03 | 3.56e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NELL1 | SNV | Missense_Mutation | c.1599A>T | p.Lys533Asn | p.K533N | protein_coding | tolerated(0.06) | benign(0.419) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | ||
NELL1 | SNV | Missense_Mutation | c.491G>T | p.Arg164Met | p.R164M | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-55-8090-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
NELL1 | SNV | Missense_Mutation | c.2438G>T | p.Gly813Val | p.G813V | protein_coding | deleterious(0.01) | possibly_damaging(0.691) | TCGA-55-8615-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | ||
NELL1 | SNV | Missense_Mutation | c.230C>T | p.Ser77Phe | p.S77F | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-62-A46R-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NELL1 | SNV | Missense_Mutation | c.963G>C | p.Arg321Ser | p.R321S | protein_coding | tolerated(0.15) | possibly_damaging(0.447) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
NELL1 | SNV | Missense_Mutation | c.757N>A | p.His253Asn | p.H253N | protein_coding | deleterious(0.02) | benign(0.017) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | ||
NELL1 | SNV | Missense_Mutation | c.2020N>C | p.Val674Leu | p.V674L | protein_coding | tolerated(0.07) | probably_damaging(0.952) | TCGA-73-4670-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD | ||
NELL1 | SNV | Missense_Mutation | novel | c.1767N>G | p.His589Gln | p.H589Q | protein_coding | tolerated(0.32) | probably_damaging(0.994) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD | |
NELL1 | SNV | Missense_Mutation | c.1093N>A | p.Tyr365Asn | p.Y365N | protein_coding | deleterious(0.01) | probably_damaging(0.921) | TCGA-78-7146-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
NELL1 | SNV | Missense_Mutation | c.1007C>A | p.Ser336Tyr | p.S336Y | protein_coding | tolerated(0.25) | benign(0.361) | TCGA-78-7152-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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