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Gene: MYH7B |
Gene summary for MYH7B |
Gene summary. |
Gene information | Species | Human | Gene symbol | MYH7B | Gene ID | 57644 |
Gene name | myosin heavy chain 7B | |
Gene Alias | MHC14 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A7E2Y1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57644 | MYH7B | HCC1 | Human | Liver | HCC | 9.55e-11 | 6.11e+00 | 0.5336 |
57644 | MYH7B | S014 | Human | Liver | HCC | 1.60e-31 | 3.32e+00 | 0.2254 |
57644 | MYH7B | S015 | Human | Liver | HCC | 1.19e-15 | 2.49e+00 | 0.2375 |
57644 | MYH7B | S016 | Human | Liver | HCC | 3.55e-37 | 3.15e+00 | 0.2243 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYH7B | SNV | Missense_Mutation | c.5392N>T | p.Arg1798Trp | p.R1798W | A7E2Y1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MYH7B | SNV | Missense_Mutation | novel | c.2098N>T | p.His700Tyr | p.H700Y | A7E2Y1 | protein_coding | tolerated(0.24) | probably_damaging(0.969) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
MYH7B | SNV | Missense_Mutation | novel | c.2131N>A | p.Leu711Met | p.L711M | A7E2Y1 | protein_coding | deleterious(0.01) | possibly_damaging(0.806) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
MYH7B | SNV | Missense_Mutation | novel | c.4630N>A | p.Leu1544Met | p.L1544M | A7E2Y1 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
MYH7B | SNV | Missense_Mutation | novel | c.1112G>T | p.Gly371Val | p.G371V | A7E2Y1 | protein_coding | tolerated(0.22) | benign(0.074) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYH7B | SNV | Missense_Mutation | rs373972122 | c.5237G>A | p.Arg1746His | p.R1746H | A7E2Y1 | protein_coding | deleterious(0.01) | benign(0.018) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYH7B | SNV | Missense_Mutation | novel | c.5378C>T | p.Ala1793Val | p.A1793V | A7E2Y1 | protein_coding | tolerated(0.15) | benign(0.199) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYH7B | SNV | Missense_Mutation | rs201578499 | c.2060N>A | p.Arg687His | p.R687H | A7E2Y1 | protein_coding | tolerated(0.08) | possibly_damaging(0.706) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
MYH7B | SNV | Missense_Mutation | novel | c.5586N>T | p.Gln1862His | p.Q1862H | A7E2Y1 | protein_coding | deleterious(0.03) | possibly_damaging(0.7) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MYH7B | SNV | Missense_Mutation | c.4715N>C | p.Ile1572Thr | p.I1572T | A7E2Y1 | protein_coding | deleterious(0.04) | benign(0.219) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57644 | MYH7B | NA | activator | CHEMBL1800955 | OMECAMTIV MECARBIL |
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