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Gene: MYCBP2 |
Gene summary for MYCBP2 |
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Gene information | Species | Human | Gene symbol | MYCBP2 | Gene ID | 23077 |
Gene name | MYC binding protein 2 | |
Gene Alias | Myc-bp2 | |
Cytomap | 13q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75592 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23077 | MYCBP2 | CA_HPV_1 | Human | Cervix | CC | 7.00e-03 | -3.50e-02 | 0.0264 |
23077 | MYCBP2 | N_HPV_2 | Human | Cervix | N_HPV | 1.09e-02 | 8.43e-02 | -0.0131 |
23077 | MYCBP2 | CCI_1 | Human | Cervix | CC | 5.43e-07 | 1.10e+00 | 0.528 |
23077 | MYCBP2 | CCI_2 | Human | Cervix | CC | 3.05e-16 | 1.55e+00 | 0.5249 |
23077 | MYCBP2 | CCI_3 | Human | Cervix | CC | 3.17e-11 | 1.17e+00 | 0.516 |
23077 | MYCBP2 | sample3 | Human | Cervix | CC | 2.45e-02 | 9.83e-02 | 0.1387 |
23077 | MYCBP2 | T3 | Human | Cervix | CC | 4.05e-03 | 9.99e-02 | 0.1389 |
23077 | MYCBP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.10e-17 | -6.24e-01 | 0.0155 |
23077 | MYCBP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.63e-06 | -5.58e-01 | -0.1808 |
23077 | MYCBP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.18e-09 | -6.96e-01 | -0.1207 |
23077 | MYCBP2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.85e-03 | -5.11e-01 | -0.1526 |
23077 | MYCBP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.12e-13 | -5.17e-01 | -0.1464 |
23077 | MYCBP2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.59e-08 | -4.74e-01 | -0.1001 |
23077 | MYCBP2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.16e-02 | -6.35e-01 | -0.2061 |
23077 | MYCBP2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.48e-02 | -4.10e-01 | -0.0179 |
23077 | MYCBP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.83e-09 | -4.58e-01 | 0.096 |
23077 | MYCBP2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.23e-05 | -4.54e-01 | 0.0338 |
23077 | MYCBP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.40e-04 | -2.70e-01 | 0.0674 |
23077 | MYCBP2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.20e-04 | -4.38e-01 | 0.0588 |
23077 | MYCBP2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.28e-02 | -2.95e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:190332010 | Cervix | CC | regulation of protein modification by small protein conjugation or removal | 66/2311 | 242/18723 | 2.31e-10 | 3.46e-08 | 66 |
GO:003139610 | Cervix | CC | regulation of protein ubiquitination | 59/2311 | 210/18723 | 5.90e-10 | 7.51e-08 | 59 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:00509203 | Cervix | CC | regulation of chemotaxis | 51/2311 | 223/18723 | 8.03e-06 | 1.86e-04 | 51 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00076238 | Cervix | CC | circadian rhythm | 46/2311 | 210/18723 | 6.76e-05 | 9.60e-04 | 46 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:004217710 | Cervix | CC | negative regulation of protein catabolic process | 30/2311 | 121/18723 | 1.23e-04 | 1.53e-03 | 30 |
GO:00329226 | Cervix | CC | circadian regulation of gene expression | 18/2311 | 68/18723 | 1.18e-03 | 9.56e-03 | 18 |
GO:00219541 | Cervix | CC | central nervous system neuron development | 19/2311 | 81/18723 | 3.96e-03 | 2.48e-02 | 19 |
GO:00313983 | Cervix | CC | positive regulation of protein ubiquitination | 25/2311 | 119/18723 | 5.09e-03 | 3.01e-02 | 25 |
GO:19033224 | Cervix | CC | positive regulation of protein modification by small protein conjugation or removal | 28/2311 | 138/18723 | 5.26e-03 | 3.08e-02 | 28 |
GO:003139625 | Cervix | N_HPV | regulation of protein ubiquitination | 24/534 | 210/18723 | 8.06e-09 | 1.60e-06 | 24 |
GO:190332025 | Cervix | N_HPV | regulation of protein modification by small protein conjugation or removal | 25/534 | 242/18723 | 3.05e-08 | 3.66e-06 | 25 |
GO:004217625 | Cervix | N_HPV | regulation of protein catabolic process | 28/534 | 391/18723 | 8.41e-06 | 2.92e-04 | 28 |
GO:00509202 | Cervix | N_HPV | regulation of chemotaxis | 19/534 | 223/18723 | 2.29e-05 | 6.37e-04 | 19 |
GO:00219531 | Cervix | N_HPV | central nervous system neuron differentiation | 11/534 | 162/18723 | 6.86e-03 | 4.55e-02 | 11 |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYCBP2 | SNV | Missense_Mutation | c.8846N>G | p.Lys2949Arg | p.K2949R | O75592 | protein_coding | deleterious(0.02) | possibly_damaging(0.899) | TCGA-AG-3999-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unspecific | PD | ||
MYCBP2 | SNV | Missense_Mutation | c.1315G>T | p.Asp439Tyr | p.D439Y | O75592 | protein_coding | deleterious(0) | possibly_damaging(0.671) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MYCBP2 | SNV | Missense_Mutation | c.5417A>T | p.Asp1806Val | p.D1806V | O75592 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EI-6513-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
MYCBP2 | SNV | Missense_Mutation | rs148009867 | c.3308N>A | p.Arg1103Gln | p.R1103Q | O75592 | protein_coding | tolerated(0.32) | benign(0) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MYCBP2 | deletion | Frame_Shift_Del | c.12140delC | p.Pro4047GlnfsTer26 | p.P4047Qfs*26 | O75592 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
MYCBP2 | deletion | Frame_Shift_Del | novel | c.9145_9146delNN | p.Asn3049Ter | p.N3049* | O75592 | protein_coding | TCGA-AA-3869-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | ||
MYCBP2 | deletion | Frame_Shift_Del | c.5600delA | p.Asn1867ThrfsTer9 | p.N1867Tfs*9 | O75592 | protein_coding | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
MYCBP2 | insertion | In_Frame_Ins | novel | c.9146_9147insGAGGAGACT | p.Asn3049delinsLysArgArgLeu | p.N3049delinsKRRL | O75592 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MYCBP2 | insertion | Frame_Shift_Ins | novel | c.4518_4519insTTTACAA | p.Thr1507PhefsTer24 | p.T1507Ffs*24 | O75592 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MYCBP2 | insertion | In_Frame_Ins | novel | c.2829_2830insAATGTGAAGACC | p.Gly943_Cys944insAsnValLysThr | p.G943_C944insNVKT | O75592 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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