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Gene: MROH7 |
Gene summary for MROH7 |
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Gene information | Species | Human | Gene symbol | MROH7 | Gene ID | 374977 |
Gene name | maestro heat like repeat family member 7 | |
Gene Alias | C1orf175 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B7Z7S6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374977 | MROH7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.06e-10 | 2.37e-01 | 0.0155 |
374977 | MROH7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.17e-11 | 3.08e-01 | -0.1808 |
374977 | MROH7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 2.80e-01 | 0.0216 |
374977 | MROH7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.73e-09 | 2.98e-01 | -0.0811 |
374977 | MROH7 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.17e-12 | 4.23e-01 | -0.1088 |
374977 | MROH7 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.93e-42 | 8.09e-01 | -0.1954 |
374977 | MROH7 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 4.38e-01 | -0.2602 |
374977 | MROH7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.93e-12 | 3.89e-01 | -0.1207 |
374977 | MROH7 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.60e-14 | 4.76e-01 | -0.1526 |
374977 | MROH7 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.84e-22 | 4.41e-01 | -0.1464 |
374977 | MROH7 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.28e-38 | 6.14e-01 | -0.1001 |
374977 | MROH7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.74e-32 | 7.54e-01 | -0.059 |
374977 | MROH7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 2.63e-01 | -0.1706 |
374977 | MROH7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.03e-03 | 2.37e-01 | -0.2061 |
374977 | MROH7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-03 | 3.08e-01 | -0.1462 |
374977 | MROH7 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.21e-19 | 6.14e-01 | -0.0842 |
374977 | MROH7 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.01e-04 | 3.68e-01 | -0.00410000000000005 |
374977 | MROH7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.36e-06 | 3.39e-01 | -0.0179 |
374977 | MROH7 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-10 | 2.55e-01 | 0.096 |
374977 | MROH7 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.89e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MROH7 | insertion | Frame_Shift_Ins | novel | c.486_487insT | p.Leu163PhefsTer10 | p.L163Ffs*10 | Q68CQ1 | protein_coding | TCGA-86-A456-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MROH7 | insertion | Frame_Shift_Ins | novel | c.3209_3210insAGCCTTCTTT | p.Gly1071AlafsTer103 | p.G1071Afs*103 | Q68CQ1 | protein_coding | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | ||
MROH7 | SNV | Missense_Mutation | novel | c.1282N>C | p.Glu428Gln | p.E428Q | Q68CQ1 | protein_coding | deleterious_low_confidence(0.03) | benign(0.208) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MROH7 | SNV | Missense_Mutation | rs554316180 | c.2101G>T | p.Ala701Ser | p.A701S | Q68CQ1 | protein_coding | deleterious(0.01) | possibly_damaging(0.881) | TCGA-CN-5363-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MROH7 | SNV | Missense_Mutation | novel | c.1843N>T | p.Leu615Phe | p.L615F | Q68CQ1 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-CV-6939-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MROH7 | SNV | Missense_Mutation | novel | c.2107G>C | p.Glu703Gln | p.E703Q | Q68CQ1 | protein_coding | deleterious(0) | possibly_damaging(0.637) | TCGA-CV-7433-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MROH7 | SNV | Missense_Mutation | rs200978433 | c.3947N>T | p.Ser1316Phe | p.S1316F | Q68CQ1 | protein_coding | deleterious_low_confidence(0) | benign(0.049) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MROH7 | SNV | Missense_Mutation | novel | c.3292N>C | p.Glu1098Gln | p.E1098Q | Q68CQ1 | protein_coding | tolerated(0.08) | probably_damaging(0.961) | TCGA-HD-7229-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
MROH7 | SNV | Missense_Mutation | novel | c.1242N>G | p.Asp414Glu | p.D414E | Q68CQ1 | protein_coding | tolerated_low_confidence(0.51) | benign(0.003) | TCGA-KK-A7AZ-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
MROH7 | SNV | Missense_Mutation | novel | c.242C>T | p.Pro81Leu | p.P81L | Q68CQ1 | protein_coding | deleterious_low_confidence(0.04) | benign(0.005) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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