![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MAPKBP1 |
Gene summary for MAPKBP1 |
![]() |
Gene information | Species | Human | Gene symbol | MAPKBP1 | Gene ID | 23005 |
Gene name | mitogen-activated protein kinase binding protein 1 | |
Gene Alias | JNKBP-1 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | O60336 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23005 | MAPKBP1 | CCI_1 | Human | Cervix | CC | 1.97e-04 | 7.96e-01 | 0.528 |
23005 | MAPKBP1 | CCI_2 | Human | Cervix | CC | 1.48e-04 | 7.22e-01 | 0.5249 |
23005 | MAPKBP1 | CCI_3 | Human | Cervix | CC | 1.35e-05 | 4.51e-01 | 0.516 |
23005 | MAPKBP1 | LZE4T | Human | Esophagus | ESCC | 3.38e-05 | 2.77e-01 | 0.0811 |
23005 | MAPKBP1 | LZE8T | Human | Esophagus | ESCC | 3.61e-07 | 2.54e-01 | 0.067 |
23005 | MAPKBP1 | LZE24T | Human | Esophagus | ESCC | 1.10e-03 | 9.30e-02 | 0.0596 |
23005 | MAPKBP1 | P2T-E | Human | Esophagus | ESCC | 2.66e-12 | 1.16e-01 | 0.1177 |
23005 | MAPKBP1 | P4T-E | Human | Esophagus | ESCC | 2.20e-11 | 2.39e-01 | 0.1323 |
23005 | MAPKBP1 | P5T-E | Human | Esophagus | ESCC | 9.04e-08 | -5.48e-03 | 0.1327 |
23005 | MAPKBP1 | P8T-E | Human | Esophagus | ESCC | 1.54e-06 | -8.63e-03 | 0.0889 |
23005 | MAPKBP1 | P9T-E | Human | Esophagus | ESCC | 1.32e-03 | 6.99e-02 | 0.1131 |
23005 | MAPKBP1 | P10T-E | Human | Esophagus | ESCC | 1.08e-21 | 2.19e-01 | 0.116 |
23005 | MAPKBP1 | P11T-E | Human | Esophagus | ESCC | 4.02e-03 | 2.23e-01 | 0.1426 |
23005 | MAPKBP1 | P12T-E | Human | Esophagus | ESCC | 1.76e-11 | 2.42e-01 | 0.1122 |
23005 | MAPKBP1 | P15T-E | Human | Esophagus | ESCC | 1.26e-06 | 1.88e-01 | 0.1149 |
23005 | MAPKBP1 | P16T-E | Human | Esophagus | ESCC | 1.41e-13 | 1.68e-01 | 0.1153 |
23005 | MAPKBP1 | P20T-E | Human | Esophagus | ESCC | 7.76e-07 | 1.95e-01 | 0.1124 |
23005 | MAPKBP1 | P21T-E | Human | Esophagus | ESCC | 1.03e-18 | 2.57e-01 | 0.1617 |
23005 | MAPKBP1 | P22T-E | Human | Esophagus | ESCC | 9.15e-17 | 1.17e-01 | 0.1236 |
23005 | MAPKBP1 | P23T-E | Human | Esophagus | ESCC | 1.77e-07 | 2.69e-01 | 0.108 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
GO:00028315 | Cervix | CC | regulation of response to biotic stimulus | 67/2311 | 327/18723 | 1.79e-05 | 3.36e-04 | 67 |
GO:00431228 | Cervix | CC | regulation of I-kappaB kinase/NF-kappaB signaling | 53/2311 | 249/18723 | 4.50e-05 | 6.87e-04 | 53 |
GO:00072497 | Cervix | CC | I-kappaB kinase/NF-kappaB signaling | 56/2311 | 281/18723 | 1.81e-04 | 2.12e-03 | 56 |
GO:00028322 | Cervix | CC | negative regulation of response to biotic stimulus | 27/2311 | 108/18723 | 2.27e-04 | 2.55e-03 | 27 |
GO:00507773 | Cervix | CC | negative regulation of immune response | 41/2311 | 194/18723 | 3.63e-04 | 3.76e-03 | 41 |
GO:00321022 | Cervix | CC | negative regulation of response to external stimulus | 75/2311 | 420/18723 | 5.96e-04 | 5.61e-03 | 75 |
GO:0031348 | Cervix | CC | negative regulation of defense response | 48/2311 | 258/18723 | 2.30e-03 | 1.65e-02 | 48 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:000283212 | Esophagus | ESCC | negative regulation of response to biotic stimulus | 72/8552 | 108/18723 | 8.36e-06 | 8.11e-05 | 72 |
GO:00507775 | Esophagus | ESCC | negative regulation of immune response | 112/8552 | 194/18723 | 4.67e-04 | 2.62e-03 | 112 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:004312218 | Oral cavity | OSCC | regulation of I-kappaB kinase/NF-kappaB signaling | 155/7305 | 249/18723 | 7.79e-14 | 4.14e-12 | 155 |
GO:000724910 | Oral cavity | OSCC | I-kappaB kinase/NF-kappaB signaling | 169/7305 | 281/18723 | 4.69e-13 | 2.25e-11 | 169 |
GO:00028317 | Oral cavity | OSCC | regulation of response to biotic stimulus | 177/7305 | 327/18723 | 1.73e-08 | 3.43e-07 | 177 |
GO:00028324 | Oral cavity | OSCC | negative regulation of response to biotic stimulus | 65/7305 | 108/18723 | 6.62e-06 | 7.29e-05 | 65 |
GO:000268310 | Oral cavity | OSCC | negative regulation of immune system process | 204/7305 | 434/18723 | 3.72e-04 | 2.27e-03 | 204 |
GO:00507774 | Oral cavity | OSCC | negative regulation of immune response | 97/7305 | 194/18723 | 1.16e-03 | 5.91e-03 | 97 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAPKBP1 | SNV | Missense_Mutation | novel | c.1471G>C | p.Gly491Arg | p.G491R | O60336 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-7250-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MAPKBP1 | SNV | Missense_Mutation | rs756380624 | c.1271N>A | p.Arg424His | p.R424H | O60336 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAPKBP1 | SNV | Missense_Mutation | novel | c.2813N>G | p.Glu938Gly | p.E938G | O60336 | protein_coding | tolerated(0.11) | benign(0.07) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAPKBP1 | SNV | Missense_Mutation | rs751962626 | c.4523N>A | p.Arg1508Gln | p.R1508Q | O60336 | protein_coding | deleterious(0.04) | possibly_damaging(0.677) | TCGA-HD-A633-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAPKBP1 | SNV | Missense_Mutation | c.1363G>T | p.Gly455Trp | p.G455W | O60336 | protein_coding | deleterious(0) | probably_damaging(0.933) | TCGA-EJ-7125-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
MAPKBP1 | SNV | Missense_Mutation | novel | c.4123N>A | p.Val1375Ile | p.V1375I | O60336 | protein_coding | tolerated(0.49) | benign(0.036) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
MAPKBP1 | SNV | Missense_Mutation | c.3982N>T | p.Pro1328Ser | p.P1328S | O60336 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAPKBP1 | SNV | Missense_Mutation | c.1040C>T | p.Thr347Ile | p.T347I | O60336 | protein_coding | deleterious(0) | possibly_damaging(0.459) | TCGA-BR-7703-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MAPKBP1 | SNV | Missense_Mutation | rs765785391 | c.1826G>A | p.Arg609Gln | p.R609Q | O60336 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAPKBP1 | SNV | Missense_Mutation | c.1766N>T | p.Ala589Val | p.A589V | O60336 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |