![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ITGA10 |
Gene summary for ITGA10 |
![]() |
Gene information | Species | Human | Gene symbol | ITGA10 | Gene ID | 8515 |
Gene name | integrin subunit alpha 10 | |
Gene Alias | PRO827 | |
Cytomap | 1q21.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | B4E282 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8515 | ITGA10 | ATC11 | Human | Thyroid | ATC | 3.71e-05 | 7.14e-01 | 0.3386 |
8515 | ITGA10 | ATC12 | Human | Thyroid | ATC | 4.84e-63 | 1.29e+00 | 0.34 |
8515 | ITGA10 | ATC3 | Human | Thyroid | ATC | 5.97e-08 | 6.02e-01 | 0.338 |
8515 | ITGA10 | ATC4 | Human | Thyroid | ATC | 1.29e-70 | 1.46e+00 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158928 | Thyroid | ATC | cell-substrate adhesion | 195/6293 | 363/18723 | 1.58e-15 | 1.17e-13 | 195 |
GO:0007160111 | Thyroid | ATC | cell-matrix adhesion | 128/6293 | 233/18723 | 1.49e-11 | 5.41e-10 | 128 |
GO:000722919 | Thyroid | ATC | integrin-mediated signaling pathway | 63/6293 | 107/18723 | 7.09e-08 | 1.24e-06 | 63 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
COL1A1 | ITGA10_ITGB1 | COL1A1_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL1A2 | ITGA10_ITGB1 | COL1A2_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL4A1 | ITGA10_ITGB1 | COL4A1_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL4A2 | ITGA10_ITGB1 | COL4A2_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL4A3 | ITGA10_ITGB1 | COL4A3_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL4A4 | ITGA10_ITGB1 | COL4A4_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL6A1 | ITGA10_ITGB1 | COL6A1_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL6A2 | ITGA10_ITGB1 | COL6A2_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL6A3 | ITGA10_ITGB1 | COL6A3_ITGA10_ITGB1 | COLLAGEN | Liver | Precancer |
COL1A1 | ITGA10_ITGB1 | COL1A1_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL1A2 | ITGA10_ITGB1 | COL1A2_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL4A1 | ITGA10_ITGB1 | COL4A1_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL4A2 | ITGA10_ITGB1 | COL4A2_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL4A3 | ITGA10_ITGB1 | COL4A3_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL6A1 | ITGA10_ITGB1 | COL6A1_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL6A2 | ITGA10_ITGB1 | COL6A2_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL6A3 | ITGA10_ITGB1 | COL6A3_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
COL9A2 | ITGA10_ITGB1 | COL9A2_ITGA10_ITGB1 | COLLAGEN | THCA | ADJ |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITGA10 | SNV | Missense_Mutation | novel | c.1882N>T | p.Asp628Tyr | p.D628Y | O75578 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-85-A4JB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | CR |
ITGA10 | SNV | Missense_Mutation | c.2690A>T | p.Glu897Val | p.E897V | O75578 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ITGA10 | SNV | Missense_Mutation | novel | c.1585N>G | p.Gln529Glu | p.Q529E | O75578 | protein_coding | tolerated(0.8) | benign(0.275) | TCGA-NC-A5HN-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ITGA10 | insertion | Frame_Shift_Ins | novel | c.1438_1439insG | p.Glu480GlyfsTer10 | p.E480Gfs*10 | O75578 | protein_coding | TCGA-22-0944-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ITGA10 | SNV | Missense_Mutation | rs199533163 | c.2006N>A | p.Arg669Gln | p.R669Q | O75578 | protein_coding | tolerated(0.09) | benign(0.363) | TCGA-CN-5367-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ITGA10 | SNV | Missense_Mutation | novel | c.2094N>C | p.Met698Ile | p.M698I | O75578 | protein_coding | tolerated(1) | benign(0) | TCGA-CV-6441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ITGA10 | SNV | Missense_Mutation | novel | c.631N>A | p.Glu211Lys | p.E211K | O75578 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITGA10 | SNV | Missense_Mutation | c.1223N>A | p.Arg408His | p.R408H | O75578 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-CV-A45P-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ITGA10 | SNV | Missense_Mutation | novel | c.1324N>A | p.Gly442Ser | p.G442S | O75578 | protein_coding | tolerated(0.73) | benign(0.03) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITGA10 | SNV | Missense_Mutation | novel | c.2339A>T | p.Gln780Leu | p.Q780L | O75578 | protein_coding | deleterious(0) | benign(0.065) | TCGA-MT-A51X-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |