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Gene: FOXP2 |
Gene summary for FOXP2 |
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Gene information | Species | Human | Gene symbol | FOXP2 | Gene ID | 93986 |
Gene name | forkhead box P2 | |
Gene Alias | CAGH44 | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B7ZLK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93986 | FOXP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.19e-65 | -1.08e+00 | 0.0155 |
93986 | FOXP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.30e-27 | -1.01e+00 | -0.1808 |
93986 | FOXP2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.08e-11 | -1.26e+00 | 0.0216 |
93986 | FOXP2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.14e-26 | -1.23e+00 | -0.0811 |
93986 | FOXP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.12e-13 | -7.61e-01 | -0.1088 |
93986 | FOXP2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.65e-06 | -1.01e+00 | -0.2196 |
93986 | FOXP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.40e-30 | -1.20e+00 | -0.1207 |
93986 | FOXP2 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.75e-10 | -7.26e-01 | -0.1526 |
93986 | FOXP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.66e-27 | -6.93e-01 | -0.1464 |
93986 | FOXP2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.16e-17 | -6.68e-01 | -0.1001 |
93986 | FOXP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.15e-28 | -9.29e-01 | -0.059 |
93986 | FOXP2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.16e-03 | -7.15e-01 | -0.1706 |
93986 | FOXP2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.91e-18 | -1.04e+00 | -0.2061 |
93986 | FOXP2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.54e-10 | -9.21e-01 | -0.1462 |
93986 | FOXP2 | HTA11_9341_2000001011 | Human | Colorectum | SER | 7.00e-12 | -9.35e-01 | -0.00410000000000005 |
93986 | FOXP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.03e-58 | -1.26e+00 | 0.096 |
93986 | FOXP2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.50e-12 | -9.65e-01 | 0.0446 |
93986 | FOXP2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.22e-14 | -1.10e+00 | 0.0451 |
93986 | FOXP2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.21e-16 | -1.31e+00 | 0.0528 |
93986 | FOXP2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.40e-05 | -4.46e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048857 | Colorectum | AD | neural nucleus development | 27/3918 | 64/18723 | 9.57e-05 | 1.45e-03 | 27 |
GO:1901654 | Colorectum | AD | response to ketone | 59/3918 | 194/18723 | 1.14e-03 | 1.04e-02 | 59 |
GO:00488571 | Colorectum | SER | neural nucleus development | 26/2897 | 64/18723 | 1.09e-06 | 5.11e-05 | 26 |
GO:19016541 | Colorectum | SER | response to ketone | 44/2897 | 194/18723 | 5.01e-03 | 3.88e-02 | 44 |
GO:00488572 | Colorectum | MSS | neural nucleus development | 26/3467 | 64/18723 | 3.19e-05 | 6.30e-04 | 26 |
GO:19016542 | Colorectum | MSS | response to ketone | 58/3467 | 194/18723 | 7.70e-05 | 1.28e-03 | 58 |
GO:00488573 | Colorectum | MSI-H | neural nucleus development | 13/1319 | 64/18723 | 4.43e-04 | 9.50e-03 | 13 |
GO:19016543 | Colorectum | MSI-H | response to ketone | 26/1319 | 194/18723 | 1.17e-03 | 1.92e-02 | 26 |
GO:19016544 | Colorectum | FAP | response to ketone | 45/2622 | 194/18723 | 3.67e-04 | 4.63e-03 | 45 |
GO:00488574 | Colorectum | FAP | neural nucleus development | 19/2622 | 64/18723 | 8.94e-04 | 9.08e-03 | 19 |
GO:0021987 | Colorectum | FAP | cerebral cortex development | 28/2622 | 114/18723 | 1.80e-03 | 1.55e-02 | 28 |
GO:0021543 | Colorectum | FAP | pallium development | 36/2622 | 169/18723 | 6.06e-03 | 3.81e-02 | 36 |
GO:0030900 | Colorectum | FAP | forebrain development | 70/2622 | 379/18723 | 8.64e-03 | 4.98e-02 | 70 |
GO:00309001 | Colorectum | CRC | forebrain development | 66/2078 | 379/18723 | 1.36e-04 | 2.57e-03 | 66 |
GO:00488575 | Colorectum | CRC | neural nucleus development | 17/2078 | 64/18723 | 4.59e-04 | 6.70e-03 | 17 |
GO:00219871 | Colorectum | CRC | cerebral cortex development | 24/2078 | 114/18723 | 1.45e-03 | 1.57e-02 | 24 |
GO:00215431 | Colorectum | CRC | pallium development | 32/2078 | 169/18723 | 1.74e-03 | 1.79e-02 | 32 |
GO:0021537 | Colorectum | CRC | telencephalon development | 43/2078 | 248/18723 | 2.01e-03 | 2.01e-02 | 43 |
GO:190165420 | Esophagus | HGIN | response to ketone | 48/2587 | 194/18723 | 3.17e-05 | 8.12e-04 | 48 |
GO:00335748 | Esophagus | HGIN | response to testosterone | 15/2587 | 42/18723 | 3.03e-04 | 5.13e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXP2 | SNV | Missense_Mutation | novel | c.1742N>G | p.Leu581Arg | p.L581R | O15409 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-IN-A7NU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | taxol | PD |
FOXP2 | SNV | Missense_Mutation | rs867418322 | c.989C>T | p.Ser330Phe | p.S330F | O15409 | protein_coding | deleterious(0.02) | benign(0.362) | TCGA-MX-A5UG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
FOXP2 | SNV | Missense_Mutation | novel | c.659A>G | p.Lys220Arg | p.K220R | O15409 | protein_coding | tolerated(0.12) | probably_damaging(0.953) | TCGA-RD-A8MV-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
FOXP2 | SNV | Missense_Mutation | rs145254341 | c.2072C>T | p.Pro691Leu | p.P691L | O15409 | protein_coding | tolerated(0.17) | benign(0.062) | TCGA-RD-A8MW-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
FOXP2 | SNV | Missense_Mutation | novel | c.1715N>A | p.Thr572Asn | p.T572N | O15409 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
FOXP2 | SNV | Missense_Mutation | novel | c.995N>A | p.Ala332Glu | p.A332E | O15409 | protein_coding | tolerated(0.24) | benign(0.186) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
FOXP2 | SNV | Missense_Mutation | novel | c.163N>G | p.Gln55Glu | p.Q55E | O15409 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.953) | TCGA-VQ-A91S-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
FOXP2 | insertion | Frame_Shift_Ins | novel | c.1865dupA | p.Asn622LysfsTer13 | p.N622Kfs*13 | O15409 | protein_coding | TCGA-CD-A4MJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | ||
FOXP2 | deletion | In_Frame_Del | rs767010865 | c.643_645delNNN | p.Gln216del | p.Q216del | O15409 | protein_coding | TCGA-FP-7998-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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