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Gene: FAM184A |
Gene summary for FAM184A |
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Gene information | Species | Human | Gene symbol | FAM184A | Gene ID | 79632 |
Gene name | family with sequence similarity 184 member A | |
Gene Alias | C6orf60 | |
Cytomap | 6q22.31 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8NB25 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79632 | FAM184A | TD9 | Human | Lung | IAC | 1.01e-03 | 6.82e-01 | 0.088 |
79632 | FAM184A | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.41e-10 | 6.04e-01 | -0.2116 |
79632 | FAM184A | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.98e-02 | 5.74e-01 | -0.1941 |
79632 | FAM184A | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.37e-03 | 6.86e-01 | -0.2107 |
79632 | FAM184A | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 7.85e-04 | 3.95e-01 | -0.2119 |
79632 | FAM184A | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 7.15e-11 | 4.49e-01 | -0.0166 |
79632 | FAM184A | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 6.90e-15 | 4.96e-01 | -0.0132 |
79632 | FAM184A | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.42e-15 | 3.92e-01 | -0.013 |
79632 | FAM184A | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 8.52e-13 | 4.99e-01 | -0.0121 |
79632 | FAM184A | male-WTA | Human | Thyroid | PTC | 9.80e-14 | 5.05e-02 | 0.1037 |
79632 | FAM184A | PTC01 | Human | Thyroid | PTC | 3.95e-07 | 1.34e-01 | 0.1899 |
79632 | FAM184A | PTC05 | Human | Thyroid | PTC | 5.97e-05 | 3.27e-01 | 0.2065 |
79632 | FAM184A | PTC06 | Human | Thyroid | PTC | 7.59e-22 | 5.74e-01 | 0.2057 |
79632 | FAM184A | PTC07 | Human | Thyroid | PTC | 4.59e-36 | 7.65e-01 | 0.2044 |
79632 | FAM184A | ATC5 | Human | Thyroid | ATC | 1.52e-04 | -5.85e-02 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM184A | SNV | Missense_Mutation | c.1327G>A | p.Glu443Lys | p.E443K | Q8NB25 | protein_coding | tolerated(0.09) | probably_damaging(0.994) | TCGA-55-8094-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
FAM184A | SNV | Missense_Mutation | c.749N>T | p.Gly250Val | p.G250V | Q8NB25 | protein_coding | deleterious(0.04) | possibly_damaging(0.804) | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAM184A | SNV | Missense_Mutation | c.747N>C | p.Glu249Asp | p.E249D | Q8NB25 | protein_coding | tolerated(0.09) | probably_damaging(0.978) | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAM184A | SNV | Missense_Mutation | c.1816G>T | p.Gly606Cys | p.G606C | Q8NB25 | protein_coding | deleterious(0.02) | possibly_damaging(0.599) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
FAM184A | SNV | Missense_Mutation | c.2183N>A | p.Arg728Gln | p.R728Q | Q8NB25 | protein_coding | deleterious(0.03) | benign(0.024) | TCGA-78-8660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAM184A | SNV | Missense_Mutation | c.1342N>A | p.Glu448Lys | p.E448K | Q8NB25 | protein_coding | deleterious(0.04) | benign(0.321) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FAM184A | SNV | Missense_Mutation | c.3349C>G | p.Gln1117Glu | p.Q1117E | Q8NB25 | protein_coding | tolerated(0.67) | probably_damaging(0.979) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
FAM184A | SNV | Missense_Mutation | rs868167807 | c.2016G>T | p.Leu672Phe | p.L672F | Q8NB25 | protein_coding | tolerated(0.18) | benign(0.023) | TCGA-34-5234-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM184A | SNV | Missense_Mutation | novel | c.538N>A | p.Glu180Lys | p.E180K | Q8NB25 | protein_coding | deleterious(0.05) | probably_damaging(0.996) | TCGA-56-7822-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | eloxatin | PD |
FAM184A | SNV | Missense_Mutation | novel | c.1443N>C | p.Lys481Asn | p.K481N | Q8NB25 | protein_coding | tolerated(0.08) | probably_damaging(0.997) | TCGA-56-A62T-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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