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Gene: EIF5B |
Gene summary for EIF5B |
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Gene information | Species | Human | Gene symbol | EIF5B | Gene ID | 9669 |
Gene name | eukaryotic translation initiation factor 5B | |
Gene Alias | IF2 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | O60841 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9669 | EIF5B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.05e-07 | -4.56e-01 | 0.0155 |
9669 | EIF5B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.90e-02 | -2.02e-01 | -0.1001 |
9669 | EIF5B | A015-C-203 | Human | Colorectum | FAP | 4.53e-20 | 3.33e-02 | -0.1294 |
9669 | EIF5B | A015-C-204 | Human | Colorectum | FAP | 6.51e-04 | 2.60e-01 | -0.0228 |
9669 | EIF5B | A014-C-040 | Human | Colorectum | FAP | 1.02e-02 | 3.05e-01 | -0.1184 |
9669 | EIF5B | A002-C-201 | Human | Colorectum | FAP | 9.30e-06 | -4.48e-02 | 0.0324 |
9669 | EIF5B | A001-C-119 | Human | Colorectum | FAP | 1.33e-03 | 2.11e-01 | -0.1557 |
9669 | EIF5B | A001-C-108 | Human | Colorectum | FAP | 1.67e-18 | 3.58e-01 | -0.0272 |
9669 | EIF5B | A002-C-205 | Human | Colorectum | FAP | 1.14e-20 | 3.13e-01 | -0.1236 |
9669 | EIF5B | A001-C-104 | Human | Colorectum | FAP | 4.46e-05 | 3.12e-01 | 0.0184 |
9669 | EIF5B | A015-C-006 | Human | Colorectum | FAP | 5.25e-22 | 5.21e-01 | -0.0994 |
9669 | EIF5B | A015-C-106 | Human | Colorectum | FAP | 1.89e-10 | 2.32e-01 | -0.0511 |
9669 | EIF5B | A002-C-114 | Human | Colorectum | FAP | 1.34e-15 | 2.09e-01 | -0.1561 |
9669 | EIF5B | A015-C-104 | Human | Colorectum | FAP | 1.08e-27 | 1.85e-01 | -0.1899 |
9669 | EIF5B | A001-C-014 | Human | Colorectum | FAP | 4.57e-14 | 2.71e-01 | 0.0135 |
9669 | EIF5B | A002-C-016 | Human | Colorectum | FAP | 8.75e-19 | 1.81e-01 | 0.0521 |
9669 | EIF5B | A015-C-002 | Human | Colorectum | FAP | 3.70e-13 | 4.05e-01 | -0.0763 |
9669 | EIF5B | A001-C-007 | Human | Colorectum | CRC | 5.72e-06 | 5.29e-01 | 0.1899 |
9669 | EIF5B | A001-C-203 | Human | Colorectum | FAP | 1.21e-10 | 1.90e-01 | -0.0481 |
9669 | EIF5B | A002-C-116 | Human | Colorectum | FAP | 5.88e-24 | -4.53e-02 | -0.0452 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0006446 | Colorectum | AD | regulation of translational initiation | 28/3918 | 79/18723 | 2.02e-03 | 1.63e-02 | 28 |
GO:00064174 | Colorectum | FAP | regulation of translation | 111/2622 | 468/18723 | 8.47e-09 | 1.13e-06 | 111 |
GO:00064463 | Colorectum | FAP | regulation of translational initiation | 26/2622 | 79/18723 | 1.54e-05 | 4.01e-04 | 26 |
GO:00064134 | Colorectum | FAP | translational initiation | 34/2622 | 118/18723 | 2.13e-05 | 5.12e-04 | 34 |
GO:00064175 | Colorectum | CRC | regulation of translation | 82/2078 | 468/18723 | 1.79e-05 | 5.40e-04 | 82 |
GO:000641310 | Endometrium | AEH | translational initiation | 42/2100 | 118/18723 | 2.68e-12 | 4.67e-10 | 42 |
GO:000641716 | Endometrium | AEH | regulation of translation | 94/2100 | 468/18723 | 1.14e-08 | 7.62e-07 | 94 |
GO:00064467 | Endometrium | AEH | regulation of translational initiation | 25/2100 | 79/18723 | 8.99e-07 | 3.19e-05 | 25 |
GO:000641315 | Endometrium | EEC | translational initiation | 42/2168 | 118/18723 | 7.65e-12 | 1.24e-09 | 42 |
GO:000641717 | Endometrium | EEC | regulation of translation | 94/2168 | 468/18723 | 5.37e-08 | 2.88e-06 | 94 |
GO:000644614 | Endometrium | EEC | regulation of translational initiation | 25/2168 | 79/18723 | 1.62e-06 | 5.03e-05 | 25 |
GO:000641727 | Esophagus | HGIN | regulation of translation | 139/2587 | 468/18723 | 1.46e-19 | 7.98e-17 | 139 |
GO:000641320 | Esophagus | HGIN | translational initiation | 55/2587 | 118/18723 | 7.33e-18 | 2.31e-15 | 55 |
GO:000644610 | Esophagus | HGIN | regulation of translational initiation | 34/2587 | 79/18723 | 2.09e-10 | 1.97e-08 | 34 |
GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:000644617 | Esophagus | ESCC | regulation of translational initiation | 65/8552 | 79/18723 | 2.04e-11 | 7.07e-10 | 65 |
GO:000641312 | Liver | Cirrhotic | translational initiation | 76/4634 | 118/18723 | 8.36e-20 | 2.18e-17 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF5B | deletion | Frame_Shift_Del | rs769971529 | c.286delN | p.Lys98ArgfsTer83 | p.K98Rfs*83 | O60841 | protein_coding | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
EIF5B | insertion | Frame_Shift_Ins | novel | c.3452_3453insA | p.Gly1154ArgfsTer14 | p.G1154Rfs*14 | O60841 | protein_coding | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
EIF5B | deletion | Frame_Shift_Del | novel | c.1159delA | p.Arg387GlufsTer15 | p.R387Efs*15 | O60841 | protein_coding | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
EIF5B | deletion | Frame_Shift_Del | rs769971529 | c.293delA | p.Lys98ArgfsTer83 | p.K98Rfs*83 | O60841 | protein_coding | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | ||
EIF5B | deletion | Frame_Shift_Del | novel | c.514delN | p.Ile174LeufsTer7 | p.I174Lfs*7 | O60841 | protein_coding | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | ||
EIF5B | insertion | Frame_Shift_Ins | novel | c.315dupA | p.Gln106ThrfsTer4 | p.Q106Tfs*4 | O60841 | protein_coding | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | ||
EIF5B | deletion | Frame_Shift_Del | rs769971529 | c.286delN | p.Lys98ArgfsTer83 | p.K98Rfs*83 | O60841 | protein_coding | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR | ||
EIF5B | insertion | Frame_Shift_Ins | novel | c.1552_1552+1insTAGAAGGAAACACAGTTCATATA | p.Lys522ThrfsTer5 | p.K522Tfs*5 | O60841 | protein_coding | TCGA-VQ-A91U-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
EIF5B | SNV | Missense_Mutation | novel | c.133A>C | p.Lys45Gln | p.K45Q | O60841 | protein_coding | deleterious_low_confidence(0.01) | benign(0.36) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
EIF5B | insertion | Frame_Shift_Ins | novel | c.469_470insCTGTTTTTTGC | p.Asn158ValfsTer27 | p.N158Vfs*27 | O60841 | protein_coding | TCGA-FY-A40L-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | levothyroxine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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