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Gene: DSC3 |
Gene summary for DSC3 |
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Gene information | Species | Human | Gene symbol | DSC3 | Gene ID | 1825 |
Gene name | desmocollin 3 | |
Gene Alias | CDHF3 | |
Cytomap | 18q12.1 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q14574 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1825 | DSC3 | GSM4909281 | Human | Breast | IDC | 1.03e-24 | 5.18e-01 | 0.21 |
1825 | DSC3 | GSM4909282 | Human | Breast | IDC | 5.16e-20 | 4.62e-01 | -0.0288 |
1825 | DSC3 | GSM4909285 | Human | Breast | IDC | 3.80e-03 | 1.41e-01 | 0.21 |
1825 | DSC3 | GSM4909286 | Human | Breast | IDC | 9.09e-10 | 2.28e-01 | 0.1081 |
1825 | DSC3 | GSM4909287 | Human | Breast | IDC | 1.49e-07 | 1.53e-01 | 0.2057 |
1825 | DSC3 | GSM4909295 | Human | Breast | IDC | 4.94e-05 | 1.82e-01 | 0.0898 |
1825 | DSC3 | GSM4909299 | Human | Breast | IDC | 8.47e-03 | 1.42e-01 | 0.035 |
1825 | DSC3 | GSM4909300 | Human | Breast | IDC | 1.67e-02 | 1.37e-01 | 0.0334 |
1825 | DSC3 | GSM4909313 | Human | Breast | IDC | 3.20e-03 | 1.12e-01 | 0.0391 |
1825 | DSC3 | brca3 | Human | Breast | Precancer | 1.09e-02 | 1.26e-01 | -0.0263 |
1825 | DSC3 | DCIS2 | Human | Breast | DCIS | 5.06e-80 | 5.64e-01 | 0.0085 |
1825 | DSC3 | CA_HPV_1 | Human | Cervix | CC | 2.48e-12 | -3.97e-01 | 0.0264 |
1825 | DSC3 | CA_HPV_3 | Human | Cervix | CC | 3.97e-22 | 5.22e-01 | 0.0414 |
1825 | DSC3 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 2.65e-05 | -3.41e-01 | 0.0116 |
1825 | DSC3 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.52e-03 | -3.31e-01 | 0.0208 |
1825 | DSC3 | N_HPV_2 | Human | Cervix | N_HPV | 6.06e-03 | 2.38e-01 | -0.0131 |
1825 | DSC3 | CCI_1 | Human | Cervix | CC | 1.78e-05 | 1.04e+00 | 0.528 |
1825 | DSC3 | CCI_2 | Human | Cervix | CC | 2.36e-02 | 8.15e-01 | 0.5249 |
1825 | DSC3 | CCI_3 | Human | Cervix | CC | 5.35e-11 | 1.32e+00 | 0.516 |
1825 | DSC3 | Tumor | Human | Cervix | CC | 3.97e-54 | 1.00e+00 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0098742 | Cervix | N_HPV | cell-cell adhesion via plasma-membrane adhesion molecules | 17/534 | 273/18723 | 2.26e-03 | 2.11e-02 | 17 |
GO:00987421 | Skin | SCCIS | cell-cell adhesion via plasma-membrane adhesion molecules | 26/919 | 273/18723 | 9.83e-04 | 1.23e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Breast | IDC |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Cervix | CC |
DSG1 | DSC3 | DSG1_DSC3 | DESMOSOME | Cervix | Healthy |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Esophagus | ADJ |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Esophagus | ESCC |
DSG1 | DSC3 | DSG1_DSC3 | DESMOSOME | HNSCC | OSCC |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | HNSCC | OSCC |
DSG1 | DSC3 | DSG1_DSC3 | DESMOSOME | HNSCC | Precancer |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | HNSCC | Precancer |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Prostate | ADJ |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Prostate | BPH |
DSG1 | DSC3 | DSG1_DSC3 | DESMOSOME | Skin | ADJ |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Skin | ADJ |
DSG1 | DSC3 | DSG1_DSC3 | DESMOSOME | Skin | AK |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Skin | AK |
DSG1 | DSC3 | DSG1_DSC3 | DESMOSOME | Skin | cSCC |
DSG1 | DSC3 | DSG1_DSC3 | DESMOSOME | Skin | Healthy |
DSG1 | DSC3 | DSG1_DSC3 | DESMOSOME | Skin | SCCIS |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DSC3 | insertion | Frame_Shift_Ins | novel | c.1143_1144insAAACTATTTAGTT | p.Asp382LysfsTer5 | p.D382Kfs*5 | Q14574 | protein_coding | TCGA-EL-A3ZN-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DSC3 | insertion | In_Frame_Ins | novel | c.1717_1718insGCAAGTCAATCT | p.Asn573delinsSerLysSerIleTyr | p.N573delinsSKSIY | Q14574 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
DSC3 | insertion | Frame_Shift_Ins | novel | c.1143_1144insTT | p.Asp382LeufsTer3 | p.D382Lfs*3 | Q14574 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
DSC3 | insertion | Frame_Shift_Ins | novel | c.1142_1143insACTATTTA | p.Asp382LeufsTer5 | p.D382Lfs*5 | Q14574 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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