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Gene: DHX57 |
Gene summary for DHX57 |
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Gene information | Species | Human | Gene symbol | DHX57 | Gene ID | 90957 |
Gene name | DExH-box helicase 57 | |
Gene Alias | DDX57 | |
Cytomap | 2p22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6P158 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90957 | DHX57 | HCC1_Meng | Human | Liver | HCC | 2.45e-39 | 1.93e-02 | 0.0246 |
90957 | DHX57 | HCC2_Meng | Human | Liver | HCC | 4.12e-09 | 4.62e-03 | 0.0107 |
90957 | DHX57 | HCC2 | Human | Liver | HCC | 3.92e-02 | 1.36e+00 | 0.5341 |
90957 | DHX57 | HCC5 | Human | Liver | HCC | 2.37e-13 | 4.90e-01 | 0.4932 |
90957 | DHX57 | S014 | Human | Liver | HCC | 8.58e-04 | 2.70e-01 | 0.2254 |
90957 | DHX57 | S015 | Human | Liver | HCC | 4.40e-04 | 3.43e-01 | 0.2375 |
90957 | DHX57 | S016 | Human | Liver | HCC | 4.78e-10 | 3.82e-01 | 0.2243 |
90957 | DHX57 | S027 | Human | Liver | HCC | 1.29e-06 | 5.05e-01 | 0.2446 |
90957 | DHX57 | S029 | Human | Liver | HCC | 1.10e-04 | 3.21e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DHX57 | SNV | Missense_Mutation | novel | c.320N>T | p.Asn107Ile | p.N107I | Q6P158 | protein_coding | deleterious(0.04) | possibly_damaging(0.873) | TCGA-CV-A6JE-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DHX57 | SNV | Missense_Mutation | c.1234N>G | p.Ile412Val | p.I412V | Q6P158 | protein_coding | tolerated(0.53) | benign(0.028) | TCGA-CH-5765-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
DHX57 | SNV | Missense_Mutation | c.215N>A | p.Arg72His | p.R72H | Q6P158 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
DHX57 | SNV | Missense_Mutation | c.2707C>T | p.Pro903Ser | p.P903S | Q6P158 | protein_coding | deleterious(0.03) | possibly_damaging(0.777) | TCGA-J4-A67M-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
DHX57 | SNV | Missense_Mutation | c.215G>A | p.Arg72His | p.R72H | Q6P158 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DHX57 | SNV | Missense_Mutation | rs754003710 | c.1157N>A | p.Arg386His | p.R386H | Q6P158 | protein_coding | tolerated(0.41) | probably_damaging(0.998) | TCGA-EQ-8122-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
DHX57 | SNV | Missense_Mutation | c.215N>A | p.Arg72His | p.R72H | Q6P158 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-FP-A4BF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
DHX57 | SNV | Missense_Mutation | c.3667N>G | p.Pro1223Ala | p.P1223A | Q6P158 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-HU-8243-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
DHX57 | SNV | Missense_Mutation | rs772949216 | c.3235N>T | p.Arg1079Cys | p.R1079C | Q6P158 | protein_coding | tolerated(0.26) | possibly_damaging(0.581) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
DHX57 | SNV | Missense_Mutation | novel | c.1300N>A | p.Asp434Asn | p.D434N | Q6P158 | protein_coding | tolerated(0.5) | benign(0.015) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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