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Gene: DENND2C |
Gene summary for DENND2C |
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Gene information | Species | Human | Gene symbol | DENND2C | Gene ID | 163259 |
Gene name | DENN domain containing 2C | |
Gene Alias | dJ1156J9.1 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q68D51 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
163259 | DENND2C | CA_HPV_2 | Human | Cervix | CC | 1.19e-05 | 3.75e-01 | 0.0391 |
163259 | DENND2C | CCI_1 | Human | Cervix | CC | 4.53e-24 | 1.82e+00 | 0.528 |
163259 | DENND2C | CCI_2 | Human | Cervix | CC | 2.13e-02 | 4.03e-01 | 0.5249 |
163259 | DENND2C | CCI_3 | Human | Cervix | CC | 4.63e-12 | 8.12e-01 | 0.516 |
163259 | DENND2C | sample3 | Human | Cervix | CC | 4.10e-10 | 3.21e-01 | 0.1387 |
163259 | DENND2C | T1 | Human | Cervix | CC | 3.11e-02 | 1.96e-01 | 0.0918 |
163259 | DENND2C | T3 | Human | Cervix | CC | 1.06e-13 | 3.47e-01 | 0.1389 |
163259 | DENND2C | LZE4T | Human | Esophagus | ESCC | 3.24e-14 | 3.96e-01 | 0.0811 |
163259 | DENND2C | LZE7T | Human | Esophagus | ESCC | 9.82e-05 | 2.65e-01 | 0.0667 |
163259 | DENND2C | LZE8T | Human | Esophagus | ESCC | 2.37e-02 | 1.79e-01 | 0.067 |
163259 | DENND2C | LZE20T | Human | Esophagus | ESCC | 3.55e-04 | 1.75e-01 | 0.0662 |
163259 | DENND2C | LZE24T | Human | Esophagus | ESCC | 2.39e-09 | 3.75e-01 | 0.0596 |
163259 | DENND2C | LZE21T | Human | Esophagus | ESCC | 4.73e-03 | 4.80e-01 | 0.0655 |
163259 | DENND2C | P1T-E | Human | Esophagus | ESCC | 5.98e-10 | 6.51e-01 | 0.0875 |
163259 | DENND2C | P2T-E | Human | Esophagus | ESCC | 3.44e-10 | 8.73e-02 | 0.1177 |
163259 | DENND2C | P4T-E | Human | Esophagus | ESCC | 1.68e-05 | 2.05e-01 | 0.1323 |
163259 | DENND2C | P5T-E | Human | Esophagus | ESCC | 7.31e-20 | 4.90e-01 | 0.1327 |
163259 | DENND2C | P8T-E | Human | Esophagus | ESCC | 6.01e-04 | 1.08e-01 | 0.0889 |
163259 | DENND2C | P9T-E | Human | Esophagus | ESCC | 5.17e-21 | 5.83e-01 | 0.1131 |
163259 | DENND2C | P10T-E | Human | Esophagus | ESCC | 3.65e-03 | 1.65e-02 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DENND2C | SNV | Missense_Mutation | novel | c.1910N>A | p.Gly637Glu | p.G637E | Q68D51 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
DENND2C | insertion | Nonsense_Mutation | novel | c.315_316insGAACTCTGAAGTT | p.His106GlufsTer3 | p.H106Efs*3 | Q68D51 | protein_coding | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DENND2C | insertion | Frame_Shift_Ins | novel | c.360_361insCCCTCCAGTTTATGCACAAGCT | p.Val121ProfsTer12 | p.V121Pfs*12 | Q68D51 | protein_coding | TCGA-77-8156-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
DENND2C | SNV | Missense_Mutation | rs756849345 | c.664N>A | p.Glu222Lys | p.E222K | Q68D51 | protein_coding | deleterious(0.04) | probably_damaging(0.91) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DENND2C | SNV | Missense_Mutation | rs781305601 | c.2147N>G | p.Tyr716Cys | p.Y716C | Q68D51 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-ZG-A9LY-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
DENND2C | SNV | Missense_Mutation | rs763423714 | c.2746N>T | p.Arg916Trp | p.R916W | Q68D51 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
DENND2C | SNV | Missense_Mutation | c.429N>A | p.Phe143Leu | p.F143L | Q68D51 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
DENND2C | SNV | Missense_Mutation | c.1544A>T | p.Gln515Leu | p.Q515L | Q68D51 | protein_coding | deleterious(0) | possibly_damaging(0.886) | TCGA-CG-4469-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
DENND2C | SNV | Missense_Mutation | novel | c.2312N>C | p.Lys771Thr | p.K771T | Q68D51 | protein_coding | deleterious(0) | possibly_damaging(0.886) | TCGA-D7-A747-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicinum | PD |
DENND2C | SNV | Missense_Mutation | rs748975071 | c.2440N>T | p.Leu814Phe | p.L814F | Q68D51 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-HU-A4H0-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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