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Gene: CRYBG3 |
Gene summary for CRYBG3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CRYBG3 | Gene ID | 131544 |
Gene name | crystallin beta-gamma domain containing 3 | |
Gene Alias | DKFZp667G2110 | |
Cytomap | 3q11.2 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q68DQ2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131544 | CRYBG3 | LZE2T | Human | Esophagus | ESCC | 3.17e-04 | 5.04e-01 | 0.082 |
131544 | CRYBG3 | LZE4T | Human | Esophagus | ESCC | 2.32e-03 | 6.26e-02 | 0.0811 |
131544 | CRYBG3 | LZE5T | Human | Esophagus | ESCC | 1.34e-04 | 4.07e-01 | 0.0514 |
131544 | CRYBG3 | LZE8T | Human | Esophagus | ESCC | 3.04e-09 | 4.49e-01 | 0.067 |
131544 | CRYBG3 | LZE20T | Human | Esophagus | ESCC | 6.34e-03 | 1.61e-01 | 0.0662 |
131544 | CRYBG3 | LZE24T | Human | Esophagus | ESCC | 1.66e-14 | 2.78e-01 | 0.0596 |
131544 | CRYBG3 | P1T-E | Human | Esophagus | ESCC | 4.95e-13 | 3.73e-01 | 0.0875 |
131544 | CRYBG3 | P2T-E | Human | Esophagus | ESCC | 1.16e-08 | 1.36e-01 | 0.1177 |
131544 | CRYBG3 | P4T-E | Human | Esophagus | ESCC | 3.47e-11 | 2.64e-01 | 0.1323 |
131544 | CRYBG3 | P5T-E | Human | Esophagus | ESCC | 5.99e-10 | 1.85e-01 | 0.1327 |
131544 | CRYBG3 | P8T-E | Human | Esophagus | ESCC | 7.43e-28 | 5.12e-01 | 0.0889 |
131544 | CRYBG3 | P9T-E | Human | Esophagus | ESCC | 3.08e-15 | 4.84e-01 | 0.1131 |
131544 | CRYBG3 | P10T-E | Human | Esophagus | ESCC | 1.11e-20 | 2.73e-01 | 0.116 |
131544 | CRYBG3 | P11T-E | Human | Esophagus | ESCC | 1.47e-03 | 1.93e-01 | 0.1426 |
131544 | CRYBG3 | P12T-E | Human | Esophagus | ESCC | 2.50e-06 | 1.71e-01 | 0.1122 |
131544 | CRYBG3 | P17T-E | Human | Esophagus | ESCC | 8.68e-03 | 1.32e-01 | 0.1278 |
131544 | CRYBG3 | P20T-E | Human | Esophagus | ESCC | 6.49e-17 | 3.59e-01 | 0.1124 |
131544 | CRYBG3 | P21T-E | Human | Esophagus | ESCC | 1.80e-19 | 4.62e-01 | 0.1617 |
131544 | CRYBG3 | P22T-E | Human | Esophagus | ESCC | 3.07e-13 | 2.37e-01 | 0.1236 |
131544 | CRYBG3 | P23T-E | Human | Esophagus | ESCC | 3.90e-17 | 5.67e-01 | 0.108 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRYBG3 | SNV | Missense_Mutation | c.7294N>T | p.Leu2432Phe | p.L2432F | Q68DQ2 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CRYBG3 | SNV | Missense_Mutation | c.6365C>A | p.Ser2122Tyr | p.S2122Y | Q68DQ2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CRYBG3 | SNV | Missense_Mutation | c.6663G>T | p.Gln2221His | p.Q2221H | Q68DQ2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CRYBG3 | SNV | Missense_Mutation | c.7718N>A | p.Ser2573Tyr | p.S2573Y | Q68DQ2 | protein_coding | deleterious(0.01) | possibly_damaging(0.852) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CRYBG3 | SNV | Missense_Mutation | c.6533C>A | p.Pro2178His | p.P2178H | Q68DQ2 | protein_coding | deleterious(0.04) | probably_damaging(0.957) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CRYBG3 | SNV | Missense_Mutation | c.7924T>G | p.Trp2642Gly | p.W2642G | Q68DQ2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CRYBG3 | SNV | Missense_Mutation | novel | c.2206N>A | p.Leu736Ile | p.L736I | Q68DQ2 | protein_coding | deleterious(0.01) | possibly_damaging(0.509) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.2813N>T | p.Ser938Ile | p.S938I | Q68DQ2 | protein_coding | deleterious_low_confidence(0.03) | benign(0.26) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.3080N>T | p.Ser1027Ile | p.S1027I | Q68DQ2 | protein_coding | deleterious(0) | possibly_damaging(0.851) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.1129N>G | p.Asn377Asp | p.N377D | Q68DQ2 | protein_coding | deleterious(0.04) | benign(0.236) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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