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Gene: CPXM2 |
Gene summary for CPXM2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CPXM2 | Gene ID | 119587 |
Gene name | carboxypeptidase X, M14 family member 2 | |
Gene Alias | CPX2 | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8N436 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
119587 | CPXM2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.65e-12 | 1.33e+00 | 0.0131 |
119587 | CPXM2 | A008-E-015 | Human | Colorectum | FAP | 5.77e-03 | 2.58e-01 | 0.0177 |
119587 | CPXM2 | P2T-E | Human | Esophagus | ESCC | 6.44e-05 | 1.62e-01 | 0.1177 |
119587 | CPXM2 | P4T-E | Human | Esophagus | ESCC | 1.05e-10 | 1.67e-01 | 0.1323 |
119587 | CPXM2 | P15T-E | Human | Esophagus | ESCC | 4.63e-03 | 8.85e-02 | 0.1149 |
119587 | CPXM2 | P16T-E | Human | Esophagus | ESCC | 1.24e-51 | 8.80e-01 | 0.1153 |
119587 | CPXM2 | P26T-E | Human | Esophagus | ESCC | 2.15e-14 | 4.36e-01 | 0.1276 |
119587 | CPXM2 | P27T-E | Human | Esophagus | ESCC | 5.12e-47 | 7.66e-01 | 0.1055 |
119587 | CPXM2 | P30T-E | Human | Esophagus | ESCC | 6.29e-12 | 4.10e-01 | 0.137 |
119587 | CPXM2 | P47T-E | Human | Esophagus | ESCC | 4.38e-02 | 4.18e-02 | 0.1067 |
119587 | CPXM2 | P48T-E | Human | Esophagus | ESCC | 4.77e-05 | 2.39e-01 | 0.0959 |
119587 | CPXM2 | P57T-E | Human | Esophagus | ESCC | 8.09e-05 | 2.74e-01 | 0.0926 |
119587 | CPXM2 | P74T-E | Human | Esophagus | ESCC | 3.51e-13 | 4.01e-01 | 0.1479 |
119587 | CPXM2 | P76T-E | Human | Esophagus | ESCC | 1.07e-15 | 3.44e-01 | 0.1207 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
GO:00164851 | Colorectum | SER | protein processing | 55/2897 | 225/18723 | 2.84e-04 | 4.67e-03 | 55 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPXM2 | SNV | Missense_Mutation | novel | c.1297G>A | p.Gly433Arg | p.G433R | Q8N436 | protein_coding | tolerated(0.54) | benign(0.021) | TCGA-QK-A8Z7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
CPXM2 | SNV | Missense_Mutation | novel | c.1346N>A | p.Gly449Glu | p.G449E | Q8N436 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CPXM2 | SNV | Missense_Mutation | rs749545644 | c.815N>A | p.Arg272His | p.R272H | Q8N436 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
CPXM2 | SNV | Missense_Mutation | rs776218004 | c.931A>G | p.Thr311Ala | p.T311A | Q8N436 | protein_coding | deleterious(0.03) | benign(0.036) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CPXM2 | SNV | Missense_Mutation | c.1463N>C | p.Leu488Pro | p.L488P | Q8N436 | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-BR-6458-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
CPXM2 | SNV | Missense_Mutation | rs78179127 | c.1903N>A | p.Val635Met | p.V635M | Q8N436 | protein_coding | deleterious(0.03) | possibly_damaging(0.847) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPXM2 | SNV | Missense_Mutation | c.2047N>G | p.Asn683Asp | p.N683D | Q8N436 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BR-8297-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | SD | |
CPXM2 | SNV | Missense_Mutation | c.904N>C | p.Tyr302His | p.Y302H | Q8N436 | protein_coding | deleterious(0.04) | benign(0.134) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CPXM2 | SNV | Missense_Mutation | rs145723018 | c.910N>T | p.Arg304Cys | p.R304C | Q8N436 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-BR-8588-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CPXM2 | SNV | Missense_Mutation | rs774426425 | c.806G>A | p.Arg269His | p.R269H | Q8N436 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-A44U-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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