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Gene: CDH6 |
Gene summary for CDH6 |
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Gene information | Species | Human | Gene symbol | CDH6 | Gene ID | 1004 |
Gene name | cadherin 6 | |
Gene Alias | CAD6 | |
Cytomap | 5p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P55285 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1004 | CDH6 | P8T-E | Human | Esophagus | ESCC | 6.93e-81 | 1.91e+00 | 0.0889 |
1004 | CDH6 | P10T-E | Human | Esophagus | ESCC | 1.66e-02 | 9.53e-02 | 0.116 |
1004 | CDH6 | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.23e-01 | 0.1287 |
1004 | CDH6 | P54T-E | Human | Esophagus | ESCC | 1.64e-05 | 3.29e-01 | 0.0975 |
1004 | CDH6 | P75T-E | Human | Esophagus | ESCC | 1.31e-36 | 9.55e-01 | 0.1125 |
1004 | CDH6 | HCC1_Meng | Human | Liver | HCC | 4.18e-06 | -2.01e-01 | 0.0246 |
1004 | CDH6 | HCC2_Meng | Human | Liver | HCC | 8.14e-07 | -1.19e-01 | 0.0107 |
1004 | CDH6 | cirrhotic2 | Human | Liver | Cirrhotic | 1.06e-08 | 2.49e-01 | 0.0201 |
1004 | CDH6 | cirrhotic3 | Human | Liver | Cirrhotic | 1.78e-03 | 9.74e-02 | 0.0215 |
1004 | CDH6 | S014 | Human | Liver | HCC | 8.82e-10 | 8.75e-01 | 0.2254 |
1004 | CDH6 | S015 | Human | Liver | HCC | 1.53e-05 | 8.35e-01 | 0.2375 |
1004 | CDH6 | S016 | Human | Liver | HCC | 1.63e-19 | 1.18e+00 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:004521620 | Esophagus | ESCC | cell-cell junction organization | 114/8552 | 200/18723 | 8.04e-04 | 4.16e-03 | 114 |
GO:004521612 | Liver | Cirrhotic | cell-cell junction organization | 70/4634 | 200/18723 | 7.23e-04 | 5.36e-03 | 70 |
GO:00070437 | Liver | Cirrhotic | cell-cell junction assembly | 50/4634 | 146/18723 | 6.23e-03 | 3.09e-02 | 50 |
GO:00343324 | Liver | Cirrhotic | adherens junction organization | 20/4634 | 49/18723 | 9.60e-03 | 4.35e-02 | 20 |
GO:004521622 | Liver | HCC | cell-cell junction organization | 107/7958 | 200/18723 | 1.06e-03 | 6.11e-03 | 107 |
GO:003433211 | Liver | HCC | adherens junction organization | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
GO:000704312 | Liver | HCC | cell-cell junction assembly | 76/7958 | 146/18723 | 1.23e-02 | 4.47e-02 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDH6 | SNV | Missense_Mutation | c.1913G>A | p.Arg638Gln | p.R638Q | P55285 | protein_coding | tolerated(0.11) | probably_damaging(0.972) | TCGA-85-7844-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CDH6 | SNV | Missense_Mutation | novel | c.107G>T | p.Arg36Met | p.R36M | P55285 | protein_coding | tolerated(0.11) | benign(0.177) | TCGA-85-A50Z-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD |
CDH6 | SNV | Missense_Mutation | novel | c.1084N>T | p.Gly362Trp | p.G362W | P55285 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-85-A511-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CDH6 | SNV | Missense_Mutation | novel | c.2047N>G | p.Ile683Val | p.I683V | P55285 | protein_coding | tolerated(0.22) | benign(0.013) | TCGA-94-8491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
CDH6 | SNV | Missense_Mutation | novel | c.2366N>G | p.Asp789Gly | p.D789G | P55285 | protein_coding | tolerated(0.08) | benign(0.02) | TCGA-NC-A5HH-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CDH6 | SNV | Missense_Mutation | rs748601134 | c.1623N>A | p.Asp541Glu | p.D541E | P55285 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-O2-A52N-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CDH6 | insertion | Frame_Shift_Ins | novel | c.137dupA | p.Asn46LysfsTer2 | p.N46Kfs*2 | P55285 | protein_coding | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | ||
CDH6 | SNV | Missense_Mutation | novel | c.910G>C | p.Glu304Gln | p.E304Q | P55285 | protein_coding | tolerated(0.2) | benign(0.017) | TCGA-BA-6870-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CDH6 | SNV | Missense_Mutation | novel | c.382N>T | p.Ala128Ser | p.A128S | P55285 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-6024-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CDH6 | SNV | Missense_Mutation | c.2089N>A | p.Leu697Ile | p.L697I | P55285 | protein_coding | tolerated(0.45) | benign(0.1) | TCGA-CN-6988-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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