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Gene: CCDC171 |
Gene summary for CCDC171 |
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Gene information | Species | Human | Gene symbol | CCDC171 | Gene ID | 203238 |
Gene name | coiled-coil domain containing 171 | |
Gene Alias | C9orf93 | |
Cytomap | 9p22.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q6TFL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
203238 | CCDC171 | AEH-subject3 | Human | Endometrium | AEH | 3.82e-02 | 2.23e-01 | -0.2576 |
203238 | CCDC171 | AEH-subject4 | Human | Endometrium | AEH | 2.35e-04 | 3.26e-01 | -0.2657 |
203238 | CCDC171 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.09e-04 | -7.02e-02 | -0.1917 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC171 | SNV | Missense_Mutation | c.2564A>C | p.Lys855Thr | p.K855T | Q6TFL3 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CCDC171 | SNV | Missense_Mutation | c.926G>T | p.Arg309Leu | p.R309L | Q6TFL3 | protein_coding | deleterious(0) | possibly_damaging(0.697) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
CCDC171 | SNV | Missense_Mutation | c.3480G>T | p.Gln1160His | p.Q1160H | Q6TFL3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCDC171 | SNV | Missense_Mutation | c.1837N>T | p.Asp613Tyr | p.D613Y | Q6TFL3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCDC171 | SNV | Missense_Mutation | novel | c.3139N>T | p.Leu1047Phe | p.L1047F | Q6TFL3 | protein_coding | tolerated(0.7) | possibly_damaging(0.865) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
CCDC171 | SNV | Missense_Mutation | c.1398N>T | p.Gln466His | p.Q466H | Q6TFL3 | protein_coding | tolerated(0.07) | benign(0.018) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCDC171 | SNV | Missense_Mutation | c.3811N>A | p.Asp1271Asn | p.D1271N | Q6TFL3 | protein_coding | tolerated_low_confidence(0.11) | benign(0.018) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CCDC171 | SNV | Missense_Mutation | c.2110N>A | p.Glu704Lys | p.E704K | Q6TFL3 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
CCDC171 | SNV | Missense_Mutation | novel | c.1166N>C | p.Leu389Pro | p.L389P | Q6TFL3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-66-2765-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CCDC171 | SNV | Missense_Mutation | c.3704N>G | p.Lys1235Arg | p.K1235R | Q6TFL3 | protein_coding | deleterious(0.01) | possibly_damaging(0.831) | TCGA-66-2767-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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