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Gene: CCDC141 |
Gene summary for CCDC141 |
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Gene information | Species | Human | Gene symbol | CCDC141 | Gene ID | 285025 |
Gene name | coiled-coil domain containing 141 | |
Gene Alias | CAMDI | |
Cytomap | 2q31.2 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | B8ZZB3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285025 | CCDC141 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 7.31e-03 | 5.54e-01 | -0.1406 |
285025 | CCDC141 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.67e-11 | 6.10e-01 | -0.2116 |
285025 | CCDC141 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.37e-02 | 4.54e-01 | -0.1941 |
285025 | CCDC141 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 7.22e-04 | 5.15e-01 | -0.2107 |
285025 | CCDC141 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.58e-07 | 4.38e-01 | -0.2119 |
285025 | CCDC141 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.39e-03 | 2.15e-01 | -0.0166 |
285025 | CCDC141 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.32e-03 | 1.56e-01 | -0.013 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00219872 | Lung | IAC | cerebral cortex development | 27/2061 | 114/18723 | 8.78e-05 | 1.77e-03 | 27 |
GO:00215432 | Lung | IAC | pallium development | 33/2061 | 169/18723 | 7.51e-04 | 9.82e-03 | 33 |
GO:00309002 | Lung | IAC | forebrain development | 61/2061 | 379/18723 | 1.52e-03 | 1.61e-02 | 61 |
GO:00516424 | Lung | IAC | centrosome localization | 10/2061 | 32/18723 | 1.68e-03 | 1.76e-02 | 10 |
GO:00618424 | Lung | IAC | microtubule organizing center localization | 10/2061 | 33/18723 | 2.18e-03 | 2.15e-02 | 10 |
GO:0021795 | Lung | IAC | cerebral cortex cell migration | 11/2061 | 42/18723 | 4.72e-03 | 3.68e-02 | 11 |
GO:0022029 | Lung | IAC | telencephalon cell migration | 13/2061 | 56/18723 | 6.78e-03 | 4.73e-02 | 13 |
GO:003090011 | Lung | AIS | forebrain development | 55/1849 | 379/18723 | 2.37e-03 | 2.48e-02 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC141 | SNV | Missense_Mutation | c.2279G>T | p.Ser760Ile | p.S760I | protein_coding | tolerated(0.06) | benign(0.381) | TCGA-CC-A7II-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | ||
CCDC141 | SNV | Missense_Mutation | c.758N>T | p.Gln253Leu | p.Q253L | protein_coding | tolerated(0.34) | benign(0.006) | TCGA-ED-A7PZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CCDC141 | SNV | Missense_Mutation | c.1393G>T | p.Gly465Cys | p.G465C | protein_coding | deleterious(0.01) | possibly_damaging(0.781) | TCGA-EP-A3JL-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CCDC141 | SNV | Missense_Mutation | c.1943C>T | p.Ser648Leu | p.S648L | protein_coding | tolerated_low_confidence(0.66) | benign(0) | TCGA-05-4415-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | ||
CCDC141 | SNV | Missense_Mutation | c.2225N>A | p.Pro742His | p.P742H | protein_coding | tolerated(0.54) | benign(0.031) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
CCDC141 | SNV | Missense_Mutation | c.1943N>T | p.Glu648Val | p.E648V | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
CCDC141 | SNV | Missense_Mutation | c.1195N>A | p.Gln399Lys | p.Q399K | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-49-4487-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
CCDC141 | SNV | Missense_Mutation | c.1810N>T | p.Asp604Tyr | p.D604Y | protein_coding | deleterious(0) | possibly_damaging(0.453) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
CCDC141 | SNV | Missense_Mutation | c.2006N>G | p.Ser669Cys | p.S669C | protein_coding | deleterious(0.01) | possibly_damaging(0.486) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CCDC141 | SNV | Missense_Mutation | c.1740N>A | p.Ser580Arg | p.S580R | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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