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Gene: ATP8B1 |
Gene summary for ATP8B1 |
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Gene information | Species | Human | Gene symbol | ATP8B1 | Gene ID | 5205 |
Gene name | ATPase phospholipid transporting 8B1 | |
Gene Alias | ATPIC | |
Cytomap | 18q21.31 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O43520 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5205 | ATP8B1 | CA_HPV_2 | Human | Cervix | CC | 2.86e-02 | 1.89e-01 | 0.0391 |
5205 | ATP8B1 | CCI_1 | Human | Cervix | CC | 7.83e-10 | 9.43e-01 | 0.528 |
5205 | ATP8B1 | CCI_2 | Human | Cervix | CC | 1.03e-08 | 9.17e-01 | 0.5249 |
5205 | ATP8B1 | CCI_3 | Human | Cervix | CC | 1.29e-11 | 9.85e-01 | 0.516 |
5205 | ATP8B1 | sample3 | Human | Cervix | CC | 1.11e-05 | 1.74e-01 | 0.1387 |
5205 | ATP8B1 | H2 | Human | Cervix | HSIL_HPV | 1.30e-06 | 2.46e-01 | 0.0632 |
5205 | ATP8B1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.00e-50 | -8.64e-01 | 0.0155 |
5205 | ATP8B1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.43e-11 | -9.18e-01 | 0.0216 |
5205 | ATP8B1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.33e-20 | 8.51e-01 | -0.1954 |
5205 | ATP8B1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.48e-10 | -5.58e-01 | -0.1207 |
5205 | ATP8B1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.17e-04 | -4.10e-01 | -0.1462 |
5205 | ATP8B1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.02e-09 | -9.56e-01 | -0.00410000000000005 |
5205 | ATP8B1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.08e-12 | -5.49e-01 | 0.096 |
5205 | ATP8B1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.45e-05 | -6.36e-01 | 0.0451 |
5205 | ATP8B1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.31e-03 | -4.20e-01 | 0.0528 |
5205 | ATP8B1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.45e-11 | -6.21e-01 | 0.0338 |
5205 | ATP8B1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.05e-13 | -4.75e-01 | 0.0674 |
5205 | ATP8B1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 4.24e-09 | -8.92e-01 | 0.0397 |
5205 | ATP8B1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.06e-12 | -6.79e-01 | 0.0588 |
5205 | ATP8B1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.47e-06 | -3.75e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:01200328 | Cervix | CC | regulation of plasma membrane bounded cell projection assembly | 38/2311 | 186/18723 | 1.14e-03 | 9.35e-03 | 38 |
GO:00604917 | Cervix | CC | regulation of cell projection assembly | 38/2311 | 188/18723 | 1.40e-03 | 1.10e-02 | 38 |
GO:00300337 | Cervix | CC | microvillus assembly | 7/2311 | 16/18723 | 1.79e-03 | 1.34e-02 | 7 |
GO:00070304 | Cervix | CC | Golgi organization | 32/2311 | 157/18723 | 2.78e-03 | 1.87e-02 | 32 |
GO:00070092 | Cervix | CC | plasma membrane organization | 28/2311 | 142/18723 | 7.85e-03 | 4.14e-02 | 28 |
GO:003003313 | Cervix | HSIL_HPV | microvillus assembly | 5/737 | 16/18723 | 2.83e-04 | 4.69e-03 | 5 |
GO:00325308 | Cervix | HSIL_HPV | regulation of microvillus organization | 4/737 | 13/18723 | 1.28e-03 | 1.48e-02 | 4 |
GO:00325287 | Cervix | HSIL_HPV | microvillus organization | 5/737 | 24/18723 | 2.12e-03 | 2.17e-02 | 5 |
GO:0032530 | Colorectum | AD | regulation of microvillus organization | 10/3918 | 13/18723 | 2.43e-05 | 4.69e-04 | 10 |
GO:0032528 | Colorectum | AD | microvillus organization | 14/3918 | 24/18723 | 6.90e-05 | 1.11e-03 | 14 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0030033 | Colorectum | AD | microvillus assembly | 9/3918 | 16/18723 | 2.06e-03 | 1.64e-02 | 9 |
GO:0042490 | Colorectum | AD | mechanoreceptor differentiation | 24/3918 | 67/18723 | 3.48e-03 | 2.52e-02 | 24 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:0060119 | Colorectum | AD | inner ear receptor cell development | 17/3918 | 45/18723 | 7.10e-03 | 4.33e-02 | 17 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:0120032 | Colorectum | AD | regulation of plasma membrane bounded cell projection assembly | 53/3918 | 186/18723 | 8.51e-03 | 4.97e-02 | 53 |
GO:00325301 | Colorectum | SER | regulation of microvillus organization | 10/2897 | 13/18723 | 1.41e-06 | 6.46e-05 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP8B1 | SNV | Missense_Mutation | novel | c.2507N>T | p.Thr836Ile | p.T836I | O43520 | protein_coding | tolerated(1) | benign(0.037) | TCGA-MT-A67A-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP8B1 | SNV | Missense_Mutation | rs764485724 | c.3728N>T | p.Ala1243Val | p.A1243V | O43520 | protein_coding | deleterious(0.02) | possibly_damaging(0.491) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
ATP8B1 | SNV | Missense_Mutation | rs536502512 | c.2338N>A | p.Ala780Thr | p.A780T | O43520 | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ATP8B1 | insertion | In_Frame_Ins | novel | c.3431_3432insTTCAGTGGTCCACAGGGCTGTACCTGTTTC | p.Tyr1144_Ile1145insSerValValHisArgAlaValProValSer | p.Y1144_I1145insSVVHRAVPVS | O43520 | protein_coding | TCGA-KC-A7F5-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | ||
ATP8B1 | insertion | Nonsense_Mutation | novel | c.299_300insA | p.Tyr100Ter | p.Y100* | O43520 | protein_coding | TCGA-V1-A8WN-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD | ||
ATP8B1 | SNV | Missense_Mutation | c.3304N>G | p.Ser1102Ala | p.S1102A | O43520 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP8B1 | SNV | Missense_Mutation | c.1295C>T | p.Thr432Ile | p.T432I | O43520 | protein_coding | tolerated(0.16) | probably_damaging(0.997) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ATP8B1 | SNV | Missense_Mutation | c.556T>C | p.Phe186Leu | p.F186L | O43520 | protein_coding | tolerated(1) | probably_damaging(0.994) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP8B1 | SNV | Missense_Mutation | rs147183894 | c.523N>C | p.Asn175His | p.N175H | O43520 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-BR-8362-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
ATP8B1 | SNV | Missense_Mutation | rs762857853 | c.2089N>T | p.Asp697Tyr | p.D697Y | O43520 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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