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Gene: ATP1A2 |
Gene summary for ATP1A2 |
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Gene information | Species | Human | Gene symbol | ATP1A2 | Gene ID | 477 |
Gene name | ATPase Na+/K+ transporting subunit alpha 2 | |
Gene Alias | FHM2 | |
Cytomap | 1q23.2 | |
Gene Type | protein-coding | GO ID | GO:0001504 | UniProtAcc | A0A0S2Z3W6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
477 | ATP1A2 | HCC1 | Human | Liver | HCC | 3.57e-07 | 2.68e+00 | 0.5336 |
477 | ATP1A2 | HCC2 | Human | Liver | HCC | 4.91e-15 | 1.23e+00 | 0.5341 |
477 | ATP1A2 | HCC5 | Human | Liver | HCC | 1.24e-04 | 7.57e-01 | 0.4932 |
477 | ATP1A2 | S014 | Human | Liver | HCC | 2.73e-09 | 5.21e-01 | 0.2254 |
477 | ATP1A2 | S015 | Human | Liver | HCC | 1.80e-10 | 8.67e-01 | 0.2375 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:004854522 | Liver | HCC | response to steroid hormone | 206/7958 | 339/18723 | 6.81e-12 | 2.92e-10 | 206 |
GO:007149622 | Liver | HCC | cellular response to external stimulus | 191/7958 | 320/18723 | 3.40e-10 | 1.13e-08 | 191 |
GO:007138322 | Liver | HCC | cellular response to steroid hormone stimulus | 128/7958 | 204/18723 | 3.92e-09 | 1.04e-07 | 128 |
GO:003297022 | Liver | HCC | regulation of actin filament-based process | 222/7958 | 397/18723 | 3.81e-08 | 8.30e-07 | 222 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:005123521 | Liver | HCC | maintenance of location | 185/7958 | 327/18723 | 1.70e-07 | 3.12e-06 | 185 |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:005165112 | Liver | HCC | maintenance of location in cell | 119/7958 | 214/18723 | 7.11e-05 | 6.39e-04 | 119 |
GO:19026007 | Liver | HCC | proton transmembrane transport | 87/7958 | 157/18723 | 7.27e-04 | 4.42e-03 | 87 |
GO:00712601 | Liver | HCC | cellular response to mechanical stimulus | 48/7958 | 81/18723 | 1.72e-03 | 8.96e-03 | 48 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
GO:015010411 | Liver | HCC | transport across blood-brain barrier | 50/7958 | 87/18723 | 3.42e-03 | 1.55e-02 | 50 |
GO:001023211 | Liver | HCC | vascular transport | 50/7958 | 88/18723 | 4.69e-03 | 2.02e-02 | 50 |
GO:00551191 | Liver | HCC | relaxation of cardiac muscle | 13/7958 | 17/18723 | 4.77e-03 | 2.02e-02 | 13 |
GO:00860642 | Liver | HCC | cell communication by electrical coupling involved in cardiac conduction | 17/7958 | 25/18723 | 8.94e-03 | 3.45e-02 | 17 |
GO:0010882 | Liver | HCC | regulation of cardiac muscle contraction by calcium ion signaling | 18/7958 | 27/18723 | 9.75e-03 | 3.66e-02 | 18 |
GO:0010881 | Liver | HCC | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 15/7958 | 22/18723 | 1.35e-02 | 4.80e-02 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491912 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491913 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP1A2 | SNV | Missense_Mutation | c.2201C>A | p.Ser734Tyr | p.S734Y | P50993 | protein_coding | deleterious(0) | benign(0.284) | TCGA-64-1679-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ATP1A2 | SNV | Missense_Mutation | c.2484N>G | p.Ile828Met | p.I828M | P50993 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-64-5815-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR | |
ATP1A2 | SNV | Missense_Mutation | novel | c.1063C>A | p.Leu355Met | p.L355M | P50993 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-78-8648-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ATP1A2 | SNV | Missense_Mutation | c.2581N>T | p.Gly861Cys | p.G861C | P50993 | protein_coding | deleterious(0.01) | benign(0.12) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP1A2 | SNV | Missense_Mutation | c.443N>T | p.Gln148Leu | p.Q148L | P50993 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-91-6831-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATP1A2 | SNV | Missense_Mutation | c.155N>T | p.Lys52Ile | p.K52I | P50993 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-97-7937-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATP1A2 | SNV | Missense_Mutation | c.2913G>A | p.Met971Ile | p.M971I | P50993 | protein_coding | tolerated(0.05) | benign(0.045) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP1A2 | SNV | Missense_Mutation | novel | c.859G>A | p.Glu287Lys | p.E287K | P50993 | protein_coding | tolerated(0.08) | benign(0.113) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP1A2 | SNV | Missense_Mutation | c.2885N>A | p.Ala962Asp | p.A962D | P50993 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ATP1A2 | SNV | Missense_Mutation | novel | c.2129N>A | p.Ala710Asp | p.A710D | P50993 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-4609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | olanzapine | OLANZAPINE | ||
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | inhibitor | CHEMBL3545057 | ACETYLDIGITOXIN | |
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | inhibitor | CHEMBL254219 | DIGITOXIN | |
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | inhibitor | CHEMBL1751 | DIGOXIN | |
477 | ATP1A2 | ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOME | inhibitor | CHEMBL1614 | DESLANOSIDE |
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