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Gene: ARFGEF1 |
Gene summary for ARFGEF1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ARFGEF1 | Gene ID | 10565 |
Gene name | ADP ribosylation factor guanine nucleotide exchange factor 1 | |
Gene Alias | ARFGEP1 | |
Cytomap | 8q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024R7X0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10565 | ARFGEF1 | CCI_1 | Human | Cervix | CC | 1.77e-04 | 7.29e-01 | 0.528 |
10565 | ARFGEF1 | CCI_2 | Human | Cervix | CC | 2.50e-10 | 1.18e+00 | 0.5249 |
10565 | ARFGEF1 | CCI_3 | Human | Cervix | CC | 7.27e-08 | 8.20e-01 | 0.516 |
10565 | ARFGEF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.19e-30 | -7.61e-01 | 0.0155 |
10565 | ARFGEF1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.79e-04 | -4.77e-01 | -0.1808 |
10565 | ARFGEF1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.03e-03 | -7.50e-01 | 0.0216 |
10565 | ARFGEF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.48e-09 | -6.77e-01 | -0.1207 |
10565 | ARFGEF1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.62e-07 | -3.86e-01 | -0.1464 |
10565 | ARFGEF1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.72e-03 | -3.16e-01 | -0.1001 |
10565 | ARFGEF1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.37e-05 | -8.05e-01 | -0.1462 |
10565 | ARFGEF1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.88e-16 | -6.56e-01 | 0.096 |
10565 | ARFGEF1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.84e-03 | -6.11e-01 | 0.0528 |
10565 | ARFGEF1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.37e-07 | -5.04e-01 | 0.0338 |
10565 | ARFGEF1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.01e-15 | -5.25e-01 | 0.0674 |
10565 | ARFGEF1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.60e-02 | -8.14e-01 | 0.0397 |
10565 | ARFGEF1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.72e-06 | -5.38e-01 | 0.0588 |
10565 | ARFGEF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.10e-11 | -4.37e-01 | 0.294 |
10565 | ARFGEF1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.87e-11 | -7.90e-01 | 0.2585 |
10565 | ARFGEF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.97e-12 | -4.47e-01 | 0.3005 |
10565 | ARFGEF1 | F007 | Human | Colorectum | FAP | 5.06e-04 | -2.40e-01 | 0.1176 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00300108 | Cervix | CC | establishment of cell polarity | 42/2311 | 143/18723 | 4.30e-08 | 2.62e-06 | 42 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
GO:19030349 | Cervix | CC | regulation of response to wounding | 44/2311 | 167/18723 | 6.33e-07 | 2.31e-05 | 44 |
GO:00081549 | Cervix | CC | actin polymerization or depolymerization | 51/2311 | 218/18723 | 4.05e-06 | 1.05e-04 | 51 |
GO:00300419 | Cervix | CC | actin filament polymerization | 45/2311 | 191/18723 | 1.20e-05 | 2.54e-04 | 45 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:00465785 | Cervix | CC | regulation of Ras protein signal transduction | 44/2311 | 189/18723 | 2.05e-05 | 3.73e-04 | 44 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041448 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa041449 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414434 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARFGEF1 | SNV | Missense_Mutation | novel | c.4771T>C | p.Ser1591Pro | p.S1591P | Q9Y6D6 | protein_coding | tolerated(0.24) | benign(0.012) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ARFGEF1 | SNV | Missense_Mutation | c.2107G>A | p.Glu703Lys | p.E703K | Q9Y6D6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARFGEF1 | SNV | Missense_Mutation | novel | c.243C>A | p.Phe81Leu | p.F81L | Q9Y6D6 | protein_coding | tolerated(0.15) | benign(0.175) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ARFGEF1 | SNV | Missense_Mutation | novel | c.2604N>T | p.Glu868Asp | p.E868D | Q9Y6D6 | protein_coding | tolerated(0.24) | benign(0.428) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARFGEF1 | SNV | Missense_Mutation | novel | c.2054N>A | p.Gly685Asp | p.G685D | Q9Y6D6 | protein_coding | tolerated(0.64) | benign(0.09) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARFGEF1 | SNV | Missense_Mutation | novel | c.788N>A | p.Gly263Glu | p.G263E | Q9Y6D6 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARFGEF1 | SNV | Missense_Mutation | novel | c.2761A>G | p.Thr921Ala | p.T921A | Q9Y6D6 | protein_coding | tolerated(0.12) | benign(0.275) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARFGEF1 | SNV | Missense_Mutation | c.5156N>C | p.Leu1719Pro | p.L1719P | Q9Y6D6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0U7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARFGEF1 | SNV | Missense_Mutation | c.3176T>G | p.Leu1059Arg | p.L1059R | Q9Y6D6 | protein_coding | deleterious(0.01) | possibly_damaging(0.728) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARFGEF1 | SNV | Missense_Mutation | c.5042A>C | p.Lys1681Thr | p.K1681T | Q9Y6D6 | protein_coding | tolerated(0.41) | benign(0.04) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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