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Gene: ADAMTS5 |
Gene summary for ADAMTS5 |
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Gene information | Species | Human | Gene symbol | ADAMTS5 | Gene ID | 11096 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 5 | |
Gene Alias | ADAM-TS 11 | |
Cytomap | 21q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | Q9UNA0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11096 | ADAMTS5 | ATC13 | Human | Thyroid | ATC | 6.21e-57 | 1.69e+00 | 0.34 |
11096 | ADAMTS5 | ATC2 | Human | Thyroid | ATC | 3.27e-02 | 1.44e-01 | 0.34 |
11096 | ADAMTS5 | ATC5 | Human | Thyroid | ATC | 5.95e-74 | 1.78e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002241124 | Thyroid | ATC | cellular component disassembly | 248/6293 | 443/18723 | 1.34e-22 | 3.69e-20 | 248 |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:004269216 | Thyroid | ATC | muscle cell differentiation | 165/6293 | 384/18723 | 7.17e-05 | 5.46e-04 | 165 |
GO:010610621 | Thyroid | ATC | cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:012016121 | Thyroid | ATC | regulation of cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:199084521 | Thyroid | ATC | adaptive thermogenesis | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
GO:005114617 | Thyroid | ATC | striated muscle cell differentiation | 119/6293 | 283/18723 | 1.74e-03 | 8.70e-03 | 119 |
GO:000165912 | Thyroid | ATC | temperature homeostasis | 73/6293 | 174/18723 | 1.29e-02 | 4.51e-02 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS5 | SNV | Missense_Mutation | novel | c.2186N>A | p.Ser729Tyr | p.S729Y | Q9UNA0 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-55-8096-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ADAMTS5 | SNV | Missense_Mutation | c.1790C>A | p.Pro597His | p.P597H | Q9UNA0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ADAMTS5 | SNV | Missense_Mutation | c.2155N>T | p.Asp719Tyr | p.D719Y | Q9UNA0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
ADAMTS5 | SNV | Missense_Mutation | c.1918N>A | p.Gln640Lys | p.Q640K | Q9UNA0 | protein_coding | tolerated(0.06) | benign(0.137) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
ADAMTS5 | SNV | Missense_Mutation | novel | c.1372N>T | p.Ala458Ser | p.A458S | Q9UNA0 | protein_coding | tolerated(0.35) | benign(0.206) | TCGA-64-5774-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ADAMTS5 | SNV | Missense_Mutation | c.1211N>A | p.Ala404Glu | p.A404E | Q9UNA0 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-67-6217-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD | |
ADAMTS5 | SNV | Missense_Mutation | novel | c.1396G>T | p.Asp466Tyr | p.D466Y | Q9UNA0 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-73-4658-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADAMTS5 | SNV | Missense_Mutation | rs764978163 | c.951N>T | p.Lys317Asn | p.K317N | Q9UNA0 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-73-4662-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ADAMTS5 | SNV | Missense_Mutation | novel | c.1444N>T | p.Gly482Cys | p.G482C | Q9UNA0 | protein_coding | deleterious(0.01) | possibly_damaging(0.537) | TCGA-73-4666-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ADAMTS5 | SNV | Missense_Mutation | novel | c.1768N>T | p.Ala590Ser | p.A590S | Q9UNA0 | protein_coding | tolerated(1) | possibly_damaging(0.545) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11096 | ADAMTS5 | DRUGGABLE GENOME, ENZYME, PROTEASE, NEUTRAL ZINC METALLOPEPTIDASE | inhibitor | 252166754 | ||
11096 | ADAMTS5 | DRUGGABLE GENOME, ENZYME, PROTEASE, NEUTRAL ZINC METALLOPEPTIDASE | AGG-523 | AGG-523 | ||
11096 | ADAMTS5 | DRUGGABLE GENOME, ENZYME, PROTEASE, NEUTRAL ZINC METALLOPEPTIDASE | TUMOR NECROSIS FACTOR | 11520168 |
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