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Gene: ZMIZ1 |
Gene summary for ZMIZ1 |
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Gene information | Species | Human | Gene symbol | ZMIZ1 | Gene ID | 57178 |
Gene name | zinc finger MIZ-type containing 1 | |
Gene Alias | MIZ | |
Cytomap | 10q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0JLS3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57178 | ZMIZ1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.10e-07 | 5.02e-01 | -0.1464 |
57178 | ZMIZ1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.38e-03 | 3.67e-01 | -0.1001 |
57178 | ZMIZ1 | A015-C-203 | Human | Colorectum | FAP | 7.20e-14 | -1.45e-01 | -0.1294 |
57178 | ZMIZ1 | A015-C-204 | Human | Colorectum | FAP | 2.10e-02 | -1.66e-01 | -0.0228 |
57178 | ZMIZ1 | A002-C-201 | Human | Colorectum | FAP | 4.61e-04 | -2.29e-02 | 0.0324 |
57178 | ZMIZ1 | A001-C-119 | Human | Colorectum | FAP | 1.34e-03 | -3.01e-01 | -0.1557 |
57178 | ZMIZ1 | A001-C-108 | Human | Colorectum | FAP | 4.68e-07 | -1.02e-01 | -0.0272 |
57178 | ZMIZ1 | A002-C-205 | Human | Colorectum | FAP | 4.12e-12 | -2.29e-01 | -0.1236 |
57178 | ZMIZ1 | A015-C-006 | Human | Colorectum | FAP | 2.83e-09 | -2.93e-01 | -0.0994 |
57178 | ZMIZ1 | A015-C-106 | Human | Colorectum | FAP | 2.19e-03 | 4.10e-03 | -0.0511 |
57178 | ZMIZ1 | A002-C-114 | Human | Colorectum | FAP | 9.12e-09 | -6.84e-02 | -0.1561 |
57178 | ZMIZ1 | A015-C-104 | Human | Colorectum | FAP | 5.91e-15 | -2.38e-01 | -0.1899 |
57178 | ZMIZ1 | A001-C-014 | Human | Colorectum | FAP | 3.18e-04 | -1.30e-01 | 0.0135 |
57178 | ZMIZ1 | A002-C-016 | Human | Colorectum | FAP | 2.43e-08 | -4.63e-02 | 0.0521 |
57178 | ZMIZ1 | A015-C-002 | Human | Colorectum | FAP | 1.63e-06 | -2.61e-01 | -0.0763 |
57178 | ZMIZ1 | A001-C-203 | Human | Colorectum | FAP | 2.09e-02 | -2.64e-02 | -0.0481 |
57178 | ZMIZ1 | A002-C-116 | Human | Colorectum | FAP | 1.91e-14 | -1.60e-01 | -0.0452 |
57178 | ZMIZ1 | A014-C-008 | Human | Colorectum | FAP | 1.83e-05 | -8.60e-02 | -0.191 |
57178 | ZMIZ1 | A018-E-020 | Human | Colorectum | FAP | 1.62e-09 | -1.93e-01 | -0.2034 |
57178 | ZMIZ1 | F034 | Human | Colorectum | FAP | 3.69e-07 | 7.15e-03 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903320 | Colorectum | AD | regulation of protein modification by small protein conjugation or removal | 86/3918 | 242/18723 | 9.43e-08 | 4.65e-06 | 86 |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:0030522 | Colorectum | AD | intracellular receptor signaling pathway | 87/3918 | 265/18723 | 3.69e-06 | 1.03e-04 | 87 |
GO:0043401 | Colorectum | AD | steroid hormone mediated signaling pathway | 51/3918 | 136/18723 | 6.52e-06 | 1.63e-04 | 51 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0009755 | Colorectum | AD | hormone-mediated signaling pathway | 64/3918 | 190/18723 | 2.78e-05 | 5.24e-04 | 64 |
GO:0030518 | Colorectum | AD | intracellular steroid hormone receptor signaling pathway | 43/3918 | 116/18723 | 4.61e-05 | 7.97e-04 | 43 |
GO:0030521 | Colorectum | AD | androgen receptor signaling pathway | 20/3918 | 44/18723 | 2.26e-04 | 2.94e-03 | 20 |
GO:0021859 | Colorectum | AD | pyramidal neuron differentiation | 9/3918 | 13/18723 | 2.38e-04 | 3.03e-03 | 9 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0021860 | Colorectum | AD | pyramidal neuron development | 8/3918 | 11/18723 | 3.26e-04 | 3.85e-03 | 8 |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
GO:0007179 | Colorectum | AD | transforming growth factor beta receptor signaling pathway | 59/3918 | 198/18723 | 1.94e-03 | 1.58e-02 | 59 |
GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
GO:1903706 | Colorectum | AD | regulation of hemopoiesis | 99/3918 | 367/18723 | 3.08e-03 | 2.28e-02 | 99 |
GO:0060395 | Colorectum | AD | SMAD protein signal transduction | 28/3918 | 82/18723 | 3.73e-03 | 2.63e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZMIZ1 | SNV | Missense_Mutation | rs765239404 | c.1714N>A | p.Val572Met | p.V572M | Q9ULJ6 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
ZMIZ1 | SNV | Missense_Mutation | c.2743N>G | p.Met915Val | p.M915V | Q9ULJ6 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
ZMIZ1 | SNV | Missense_Mutation | c.2105N>T | p.Ala702Val | p.A702V | Q9ULJ6 | protein_coding | deleterious(0.04) | possibly_damaging(0.882) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZMIZ1 | SNV | Missense_Mutation | c.602N>T | p.Ala201Val | p.A201V | Q9ULJ6 | protein_coding | tolerated_low_confidence(0.09) | benign(0.075) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD | |
ZMIZ1 | SNV | Missense_Mutation | rs138149224 | c.1310C>T | p.Pro437Leu | p.P437L | Q9ULJ6 | protein_coding | tolerated_low_confidence(0.06) | benign(0.048) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZMIZ1 | deletion | Frame_Shift_Del | novel | c.2752delN | p.Gln920SerfsTer87 | p.Q920Sfs*87 | Q9ULJ6 | protein_coding | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZMIZ1 | deletion | Frame_Shift_Del | novel | c.2769delN | p.Pro925ArgfsTer82 | p.P925Rfs*82 | Q9ULJ6 | protein_coding | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZMIZ1 | deletion | Frame_Shift_Del | novel | c.2774delC | p.Pro925ArgfsTer82 | p.P925Rfs*82 | Q9ULJ6 | protein_coding | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | ||
ZMIZ1 | insertion | Frame_Shift_Ins | rs746887837 | c.2768_2769insC | p.Asp926GlyfsTer28 | p.D926Gfs*28 | Q9ULJ6 | protein_coding | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | ||
ZMIZ1 | deletion | Frame_Shift_Del | novel | c.379delN | p.Pro128LeufsTer5 | p.P128Lfs*5 | Q9ULJ6 | protein_coding | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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