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Gene: ZBTB41 |
Gene summary for ZBTB41 |
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Gene information | Species | Human | Gene symbol | ZBTB41 | Gene ID | 360023 |
Gene name | zinc finger and BTB domain containing 41 | |
Gene Alias | FRBZ1 | |
Cytomap | 1q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5SVQ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
360023 | ZBTB41 | HCC1_Meng | Human | Liver | HCC | 3.08e-40 | 8.88e-02 | 0.0246 |
360023 | ZBTB41 | HCC2_Meng | Human | Liver | HCC | 9.15e-19 | 1.59e-01 | 0.0107 |
360023 | ZBTB41 | HCC1 | Human | Liver | HCC | 9.07e-05 | 2.86e+00 | 0.5336 |
360023 | ZBTB41 | HCC2 | Human | Liver | HCC | 3.78e-11 | 2.86e+00 | 0.5341 |
360023 | ZBTB41 | S016 | Human | Liver | HCC | 5.37e-03 | 1.69e-01 | 0.2243 |
360023 | ZBTB41 | S027 | Human | Liver | HCC | 5.93e-04 | 4.50e-01 | 0.2446 |
360023 | ZBTB41 | S028 | Human | Liver | HCC | 2.21e-16 | 6.04e-01 | 0.2503 |
360023 | ZBTB41 | S029 | Human | Liver | HCC | 1.13e-10 | 5.71e-01 | 0.2581 |
360023 | ZBTB41 | male-WTA | Human | Thyroid | PTC | 6.60e-10 | 1.08e-01 | 0.1037 |
360023 | ZBTB41 | PTC01 | Human | Thyroid | PTC | 3.39e-04 | 1.15e-02 | 0.1899 |
360023 | ZBTB41 | PTC04 | Human | Thyroid | PTC | 4.46e-08 | 1.18e-01 | 0.1927 |
360023 | ZBTB41 | PTC05 | Human | Thyroid | PTC | 1.56e-04 | 3.07e-01 | 0.2065 |
360023 | ZBTB41 | PTC06 | Human | Thyroid | PTC | 6.50e-20 | 3.88e-01 | 0.2057 |
360023 | ZBTB41 | PTC07 | Human | Thyroid | PTC | 3.27e-26 | 2.43e-01 | 0.2044 |
360023 | ZBTB41 | ATC12 | Human | Thyroid | ATC | 5.05e-09 | 1.15e-01 | 0.34 |
360023 | ZBTB41 | ATC13 | Human | Thyroid | ATC | 7.67e-27 | 6.42e-01 | 0.34 |
360023 | ZBTB41 | ATC2 | Human | Thyroid | ATC | 1.88e-09 | 6.30e-01 | 0.34 |
360023 | ZBTB41 | ATC4 | Human | Thyroid | ATC | 2.68e-07 | 1.72e-01 | 0.34 |
360023 | ZBTB41 | ATC5 | Human | Thyroid | ATC | 4.30e-36 | 6.77e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB41 | SNV | Missense_Mutation | c.1616N>C | p.Cys539Ser | p.C539S | Q5SVQ8 | protein_coding | deleterious(0.02) | possibly_damaging(0.517) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD | |
ZBTB41 | SNV | Missense_Mutation | c.1594N>C | p.Asn532His | p.N532H | Q5SVQ8 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-62-A46P-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZBTB41 | SNV | Missense_Mutation | c.2074N>C | p.Gly692Arg | p.G692R | Q5SVQ8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7535-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | vinblastine | PD | |
ZBTB41 | SNV | Missense_Mutation | novel | c.1906N>C | p.Cys636Arg | p.C636R | Q5SVQ8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-97-7546-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD |
ZBTB41 | SNV | Missense_Mutation | c.39N>C | p.Lys13Asn | p.K13N | Q5SVQ8 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.634) | TCGA-97-8174-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | vinorelbine | SD | |
ZBTB41 | SNV | Missense_Mutation | novel | c.1012G>T | p.Gly338Cys | p.G338C | Q5SVQ8 | protein_coding | tolerated(0.12) | benign(0.122) | TCGA-99-8032-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZBTB41 | SNV | Missense_Mutation | c.1712N>T | p.Gly571Val | p.G571V | Q5SVQ8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB41 | SNV | Missense_Mutation | c.1711N>A | p.Gly571Arg | p.G571R | Q5SVQ8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB41 | SNV | Missense_Mutation | novel | c.841N>T | p.Asn281Tyr | p.N281Y | Q5SVQ8 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB41 | SNV | Missense_Mutation | novel | c.2257N>T | p.Asp753Tyr | p.D753Y | Q5SVQ8 | protein_coding | tolerated(0.06) | possibly_damaging(0.467) | TCGA-22-1005-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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