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Gene: WDR72 |
Gene summary for WDR72 |
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Gene information | Species | Human | Gene symbol | WDR72 | Gene ID | 256764 |
Gene name | WD repeat domain 72 | |
Gene Alias | AI2A3 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | A0A087WTC3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256764 | WDR72 | CCI_3 | Human | Cervix | CC | 1.51e-08 | 5.45e-01 | 0.516 |
256764 | WDR72 | Tumor | Human | Cervix | CC | 6.51e-40 | 6.42e-01 | 0.1241 |
256764 | WDR72 | sample3 | Human | Cervix | CC | 8.48e-43 | 6.20e-01 | 0.1387 |
256764 | WDR72 | T3 | Human | Cervix | CC | 1.47e-41 | 6.24e-01 | 0.1389 |
256764 | WDR72 | LZE2D | Human | Esophagus | HGIN | 1.05e-04 | 5.49e-01 | 0.0642 |
256764 | WDR72 | LZE2T | Human | Esophagus | ESCC | 9.99e-04 | 6.59e-01 | 0.082 |
256764 | WDR72 | LZE4T | Human | Esophagus | ESCC | 3.35e-22 | 6.23e-01 | 0.0811 |
256764 | WDR72 | LZE5T | Human | Esophagus | ESCC | 1.55e-05 | 6.16e-01 | 0.0514 |
256764 | WDR72 | LZE7T | Human | Esophagus | ESCC | 3.08e-02 | 3.31e-01 | 0.0667 |
256764 | WDR72 | LZE8T | Human | Esophagus | ESCC | 6.86e-15 | 6.62e-01 | 0.067 |
256764 | WDR72 | LZE20T | Human | Esophagus | ESCC | 2.63e-10 | 5.15e-01 | 0.0662 |
256764 | WDR72 | LZE22D1 | Human | Esophagus | HGIN | 8.76e-04 | 1.64e-01 | 0.0595 |
256764 | WDR72 | LZE22T | Human | Esophagus | ESCC | 6.90e-07 | 5.94e-01 | 0.068 |
256764 | WDR72 | LZE24T | Human | Esophagus | ESCC | 1.81e-35 | 1.08e+00 | 0.0596 |
256764 | WDR72 | LZE21T | Human | Esophagus | ESCC | 9.54e-04 | 4.33e-01 | 0.0655 |
256764 | WDR72 | P1T-E | Human | Esophagus | ESCC | 2.44e-21 | 1.51e+00 | 0.0875 |
256764 | WDR72 | P2T-E | Human | Esophagus | ESCC | 5.96e-28 | 3.69e-01 | 0.1177 |
256764 | WDR72 | P4T-E | Human | Esophagus | ESCC | 5.32e-41 | 9.90e-01 | 0.1323 |
256764 | WDR72 | P5T-E | Human | Esophagus | ESCC | 1.91e-32 | 5.78e-01 | 0.1327 |
256764 | WDR72 | P8T-E | Human | Esophagus | ESCC | 1.25e-65 | 1.24e+00 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:0030198 | Cervix | CC | extracellular matrix organization | 52/2311 | 301/18723 | 7.43e-03 | 3.98e-02 | 52 |
GO:0043062 | Cervix | CC | extracellular structure organization | 52/2311 | 302/18723 | 7.92e-03 | 4.17e-02 | 52 |
GO:0022617 | Cervix | CC | extracellular matrix disassembly | 15/2311 | 63/18723 | 8.52e-03 | 4.40e-02 | 15 |
GO:0031214 | Cervix | CC | biomineral tissue development | 32/2311 | 169/18723 | 8.73e-03 | 4.48e-02 | 32 |
GO:0045229 | Cervix | CC | external encapsulating structure organization | 52/2311 | 304/18723 | 9.00e-03 | 4.57e-02 | 52 |
GO:0110148 | Cervix | CC | biomineralization | 32/2311 | 171/18723 | 1.04e-02 | 4.97e-02 | 32 |
GO:002241120 | Esophagus | HGIN | cellular component disassembly | 102/2587 | 443/18723 | 8.31e-08 | 4.33e-06 | 102 |
GO:007265920 | Esophagus | HGIN | protein localization to plasma membrane | 66/2587 | 284/18723 | 1.11e-05 | 3.18e-04 | 66 |
GO:199077818 | Esophagus | HGIN | protein localization to cell periphery | 71/2587 | 333/18723 | 1.05e-04 | 2.24e-03 | 71 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:00226172 | Esophagus | ESCC | extracellular matrix disassembly | 39/8552 | 63/18723 | 6.92e-03 | 2.52e-02 | 39 |
GO:00726597 | Liver | NAFLD | protein localization to plasma membrane | 51/1882 | 284/18723 | 2.97e-05 | 7.83e-04 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR72 | SNV | Missense_Mutation | c.3048G>T | p.Met1016Ile | p.M1016I | Q3MJ13 | protein_coding | tolerated(0.58) | benign(0) | TCGA-44-A4SU-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WDR72 | SNV | Missense_Mutation | c.3072G>A | p.Met1024Ile | p.M1024I | Q3MJ13 | protein_coding | tolerated(0.25) | benign(0) | TCGA-49-4507-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
WDR72 | SNV | Missense_Mutation | novel | c.2861N>T | p.Cys954Phe | p.C954F | Q3MJ13 | protein_coding | tolerated(0.69) | benign(0.003) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
WDR72 | SNV | Missense_Mutation | c.2689N>C | p.Glu897Gln | p.E897Q | Q3MJ13 | protein_coding | tolerated(0.32) | benign(0.007) | TCGA-50-6592-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WDR72 | SNV | Missense_Mutation | novel | c.763N>T | p.Gly255Trp | p.G255W | Q3MJ13 | protein_coding | deleterious(0.04) | probably_damaging(0.988) | TCGA-53-A4EZ-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR72 | SNV | Missense_Mutation | novel | c.2336A>C | p.Gln779Pro | p.Q779P | Q3MJ13 | protein_coding | tolerated(0.08) | benign(0.04) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WDR72 | SNV | Missense_Mutation | novel | c.1529N>T | p.Gly510Val | p.G510V | Q3MJ13 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-8614-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR72 | SNV | Missense_Mutation | rs747582414 | c.1633N>A | p.Glu545Lys | p.E545K | Q3MJ13 | protein_coding | tolerated(0.1) | benign(0.388) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
WDR72 | SNV | Missense_Mutation | c.2555N>T | p.Gly852Val | p.G852V | Q3MJ13 | protein_coding | tolerated(0.19) | benign(0.174) | TCGA-78-7158-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
WDR72 | SNV | Missense_Mutation | c.1144N>A | p.Asp382Asn | p.D382N | Q3MJ13 | protein_coding | tolerated(0.07) | benign(0.02) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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