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Gene: UBE2O |
Gene summary for UBE2O |
Gene summary. |
Gene information | Species | Human | Gene symbol | UBE2O | Gene ID | 63893 |
Gene name | ubiquitin conjugating enzyme E2 O | |
Gene Alias | E2-230K | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9C0C9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63893 | UBE2O | LZE24T | Human | Esophagus | ESCC | 1.88e-02 | 1.30e-01 | 0.0596 |
63893 | UBE2O | P2T-E | Human | Esophagus | ESCC | 6.64e-15 | 2.21e-01 | 0.1177 |
63893 | UBE2O | P4T-E | Human | Esophagus | ESCC | 1.34e-03 | 1.41e-01 | 0.1323 |
63893 | UBE2O | P5T-E | Human | Esophagus | ESCC | 4.15e-05 | 6.51e-02 | 0.1327 |
63893 | UBE2O | P8T-E | Human | Esophagus | ESCC | 5.88e-09 | 6.45e-02 | 0.0889 |
63893 | UBE2O | P9T-E | Human | Esophagus | ESCC | 2.00e-06 | 1.85e-01 | 0.1131 |
63893 | UBE2O | P10T-E | Human | Esophagus | ESCC | 2.28e-10 | 1.85e-01 | 0.116 |
63893 | UBE2O | P11T-E | Human | Esophagus | ESCC | 1.39e-05 | 2.53e-01 | 0.1426 |
63893 | UBE2O | P12T-E | Human | Esophagus | ESCC | 1.09e-06 | 1.33e-01 | 0.1122 |
63893 | UBE2O | P15T-E | Human | Esophagus | ESCC | 1.08e-17 | 4.30e-01 | 0.1149 |
63893 | UBE2O | P16T-E | Human | Esophagus | ESCC | 1.37e-08 | 1.13e-01 | 0.1153 |
63893 | UBE2O | P20T-E | Human | Esophagus | ESCC | 2.73e-17 | 4.33e-01 | 0.1124 |
63893 | UBE2O | P21T-E | Human | Esophagus | ESCC | 6.90e-08 | 1.35e-01 | 0.1617 |
63893 | UBE2O | P22T-E | Human | Esophagus | ESCC | 5.33e-12 | 8.95e-02 | 0.1236 |
63893 | UBE2O | P23T-E | Human | Esophagus | ESCC | 1.89e-04 | 1.52e-01 | 0.108 |
63893 | UBE2O | P24T-E | Human | Esophagus | ESCC | 4.73e-08 | 9.11e-02 | 0.1287 |
63893 | UBE2O | P26T-E | Human | Esophagus | ESCC | 1.28e-11 | 1.92e-01 | 0.1276 |
63893 | UBE2O | P27T-E | Human | Esophagus | ESCC | 1.35e-05 | 8.14e-02 | 0.1055 |
63893 | UBE2O | P28T-E | Human | Esophagus | ESCC | 1.38e-20 | 3.91e-01 | 0.1149 |
63893 | UBE2O | P30T-E | Human | Esophagus | ESCC | 1.01e-09 | 2.64e-01 | 0.137 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:001648210 | Esophagus | ESCC | cytosolic transport | 124/8552 | 168/18723 | 9.69e-14 | 4.69e-12 | 124 |
GO:0052547111 | Esophagus | ESCC | regulation of peptidase activity | 275/8552 | 461/18723 | 7.54e-10 | 1.88e-08 | 275 |
GO:00065136 | Esophagus | ESCC | protein monoubiquitination | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:0052548111 | Esophagus | ESCC | regulation of endopeptidase activity | 253/8552 | 432/18723 | 3.68e-08 | 6.78e-07 | 253 |
GO:007053413 | Esophagus | ESCC | protein K63-linked ubiquitination | 44/8552 | 56/18723 | 4.84e-07 | 6.50e-06 | 44 |
GO:00421477 | Esophagus | ESCC | retrograde transport, endosome to Golgi | 63/8552 | 91/18723 | 4.58e-06 | 4.87e-05 | 63 |
GO:0045861111 | Esophagus | ESCC | negative regulation of proteolysis | 195/8552 | 351/18723 | 1.13e-04 | 7.85e-04 | 195 |
GO:0051346110 | Esophagus | ESCC | negative regulation of hydrolase activity | 208/8552 | 379/18723 | 1.76e-04 | 1.14e-03 | 208 |
GO:000717810 | Esophagus | ESCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 195/8552 | 355/18723 | 2.58e-04 | 1.58e-03 | 195 |
GO:001046620 | Esophagus | ESCC | negative regulation of peptidase activity | 140/8552 | 262/18723 | 6.73e-03 | 2.46e-02 | 140 |
GO:001095119 | Esophagus | ESCC | negative regulation of endopeptidase activity | 135/8552 | 252/18723 | 6.86e-03 | 2.51e-02 | 135 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE2O | SNV | Missense_Mutation | novel | c.1217G>A | p.Cys406Tyr | p.C406Y | Q9C0C9 | protein_coding | tolerated(0.56) | benign(0.007) | TCGA-VQ-A8PU-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
UBE2O | deletion | Frame_Shift_Del | c.2277delN | p.Ile760SerfsTer16 | p.I760Sfs*16 | Q9C0C9 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
UBE2O | insertion | Frame_Shift_Ins | rs765371406 | c.3052dupC | p.His1018ProfsTer18 | p.H1018Pfs*18 | Q9C0C9 | protein_coding | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
UBE2O | SNV | Missense_Mutation | c.2637G>A | p.Met879Ile | p.M879I | Q9C0C9 | protein_coding | deleterious(0.04) | benign(0.351) | TCGA-DJ-A2PU-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBE2O | insertion | Frame_Shift_Ins | novel | c.1437_1438insAAGGCAT | p.Ala480LysfsTer5 | p.A480Kfs*5 | Q9C0C9 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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