GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160555 | Liver | NAFLD | Wnt signaling pathway | 74/1882 | 444/18723 | 8.98e-06 | 2.96e-04 | 74 |
GO:01987385 | Liver | NAFLD | cell-cell signaling by wnt | 74/1882 | 446/18723 | 1.05e-05 | 3.33e-04 | 74 |
GO:00301115 | Liver | NAFLD | regulation of Wnt signaling pathway | 57/1882 | 328/18723 | 2.79e-05 | 7.46e-04 | 57 |
GO:00608285 | Liver | NAFLD | regulation of canonical Wnt signaling pathway | 44/1882 | 253/18723 | 2.14e-04 | 3.68e-03 | 44 |
GO:00600705 | Liver | NAFLD | canonical Wnt signaling pathway | 50/1882 | 303/18723 | 3.08e-04 | 4.83e-03 | 50 |
GO:00301774 | Liver | NAFLD | positive regulation of Wnt signaling pathway | 27/1882 | 140/18723 | 6.82e-04 | 8.76e-03 | 27 |
GO:00902634 | Liver | NAFLD | positive regulation of canonical Wnt signaling pathway | 21/1882 | 106/18723 | 1.81e-03 | 1.86e-02 | 21 |
GO:00307055 | Liver | NAFLD | cytoskeleton-dependent intracellular transport | 33/1882 | 195/18723 | 1.98e-03 | 1.98e-02 | 33 |
GO:00323866 | Liver | NAFLD | regulation of intracellular transport | 49/1882 | 337/18723 | 5.34e-03 | 4.11e-02 | 49 |
GO:00109703 | Liver | NAFLD | transport along microtubule | 26/1882 | 155/18723 | 6.30e-03 | 4.69e-02 | 26 |
GO:003238621 | Liver | HCC | regulation of intracellular transport | 231/7958 | 337/18723 | 1.99e-22 | 3.40e-20 | 231 |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:00315031 | Liver | HCC | protein-containing complex localization | 129/7958 | 220/18723 | 9.38e-07 | 1.42e-05 | 129 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:003070521 | Liver | HCC | cytoskeleton-dependent intracellular transport | 111/7958 | 195/18723 | 3.25e-05 | 3.28e-04 | 111 |
GO:00109702 | Liver | HCC | transport along microtubule | 90/7958 | 155/18723 | 6.49e-05 | 5.92e-04 | 90 |
GO:006007021 | Liver | HCC | canonical Wnt signaling pathway | 162/7958 | 303/18723 | 7.00e-05 | 6.32e-04 | 162 |
GO:006082821 | Liver | HCC | regulation of canonical Wnt signaling pathway | 137/7958 | 253/18723 | 1.15e-04 | 9.70e-04 | 137 |
GO:003017721 | Liver | HCC | positive regulation of Wnt signaling pathway | 81/7958 | 140/18723 | 1.73e-04 | 1.36e-03 | 81 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC21B | SNV | Missense_Mutation | rs754751728 | c.3551N>T | p.Ala1184Val | p.A1184V | Q7Z4L5 | protein_coding | tolerated(0.08) | possibly_damaging(0.802) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTC21B | SNV | Missense_Mutation | | c.151G>A | p.Gly51Ser | p.G51S | Q7Z4L5 | protein_coding | tolerated(0.16) | possibly_damaging(0.637) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TTC21B | SNV | Missense_Mutation | rs777506886 | c.314N>T | p.Gly105Val | p.G105V | Q7Z4L5 | protein_coding | tolerated(0.18) | benign(0.034) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TTC21B | SNV | Missense_Mutation | | c.1864G>C | p.Glu622Gln | p.E622Q | Q7Z4L5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-18-4083-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
TTC21B | SNV | Missense_Mutation | | c.3283G>A | p.Glu1095Lys | p.E1095K | Q7Z4L5 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-18-5592-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TTC21B | SNV | Missense_Mutation | | c.2207T>C | p.Leu736Pro | p.L736P | Q7Z4L5 | protein_coding | deleterious(0) | benign(0.26) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TTC21B | SNV | Missense_Mutation | | c.802N>T | p.Thr268Ser | p.T268S | Q7Z4L5 | protein_coding | tolerated(1) | benign(0) | TCGA-21-1077-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TTC21B | SNV | Missense_Mutation | | c.2660N>C | p.Cys887Ser | p.C887S | Q7Z4L5 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-33-4582-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TTC21B | SNV | Missense_Mutation | | c.3638A>T | p.Tyr1213Phe | p.Y1213F | Q7Z4L5 | protein_coding | tolerated(0.61) | benign(0.092) | TCGA-33-4583-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TTC21B | SNV | Missense_Mutation | novel | c.3613N>A | p.Asp1205Asn | p.D1205N | Q7Z4L5 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-34-2609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | PD |