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Gene: TMTC1 |
Gene summary for TMTC1 |
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Gene information | Species | Human | Gene symbol | TMTC1 | Gene ID | 83857 |
Gene name | transmembrane O-mannosyltransferase targeting cadherins 1 | |
Gene Alias | ARG99 | |
Cytomap | 12p11.22 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IUR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83857 | TMTC1 | P8T-E | Human | Esophagus | ESCC | 1.72e-02 | 1.62e-01 | 0.0889 |
83857 | TMTC1 | P9T-E | Human | Esophagus | ESCC | 1.90e-04 | 1.39e-01 | 0.1131 |
83857 | TMTC1 | P10T-E | Human | Esophagus | ESCC | 3.55e-04 | 1.22e-01 | 0.116 |
83857 | TMTC1 | P12T-E | Human | Esophagus | ESCC | 1.00e-09 | 2.38e-01 | 0.1122 |
83857 | TMTC1 | P15T-E | Human | Esophagus | ESCC | 4.35e-06 | 1.68e-01 | 0.1149 |
83857 | TMTC1 | P16T-E | Human | Esophagus | ESCC | 6.44e-37 | 6.53e-01 | 0.1153 |
83857 | TMTC1 | P22T-E | Human | Esophagus | ESCC | 1.90e-07 | 1.44e-01 | 0.1236 |
83857 | TMTC1 | P23T-E | Human | Esophagus | ESCC | 5.16e-10 | 2.06e-01 | 0.108 |
83857 | TMTC1 | P26T-E | Human | Esophagus | ESCC | 4.31e-02 | 9.36e-02 | 0.1276 |
83857 | TMTC1 | P30T-E | Human | Esophagus | ESCC | 5.96e-19 | 5.71e-01 | 0.137 |
83857 | TMTC1 | P39T-E | Human | Esophagus | ESCC | 2.14e-03 | 7.62e-02 | 0.0894 |
83857 | TMTC1 | P40T-E | Human | Esophagus | ESCC | 7.99e-05 | 1.33e-01 | 0.109 |
83857 | TMTC1 | P42T-E | Human | Esophagus | ESCC | 5.08e-03 | 1.39e-01 | 0.1175 |
83857 | TMTC1 | P47T-E | Human | Esophagus | ESCC | 1.14e-02 | 5.99e-02 | 0.1067 |
83857 | TMTC1 | P48T-E | Human | Esophagus | ESCC | 2.16e-04 | 1.11e-01 | 0.0959 |
83857 | TMTC1 | P52T-E | Human | Esophagus | ESCC | 1.05e-14 | 2.88e-01 | 0.1555 |
83857 | TMTC1 | P56T-E | Human | Esophagus | ESCC | 2.21e-02 | 9.43e-01 | 0.1613 |
83857 | TMTC1 | P74T-E | Human | Esophagus | ESCC | 1.74e-02 | 1.60e-01 | 0.1479 |
83857 | TMTC1 | P107T-E | Human | Esophagus | ESCC | 3.14e-02 | 7.34e-02 | 0.171 |
83857 | TMTC1 | P128T-E | Human | Esophagus | ESCC | 1.75e-02 | 2.07e-01 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00064931 | Esophagus | ESCC | protein O-linked glycosylation | 51/8552 | 86/18723 | 7.54e-03 | 2.70e-02 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMTC1 | SNV | Missense_Mutation | novel | c.936N>A | p.Met312Ile | p.M312I | Q8IUR5 | protein_coding | deleterious(0.03) | benign(0.015) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMTC1 | SNV | Missense_Mutation | c.994N>C | p.Val332Leu | p.V332L | Q8IUR5 | protein_coding | tolerated(0.12) | benign(0.005) | TCGA-64-5779-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD | |
TMTC1 | SNV | Missense_Mutation | c.635N>T | p.Gly212Val | p.G212V | Q8IUR5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
TMTC1 | SNV | Missense_Mutation | c.1041N>T | p.Glu347Asp | p.E347D | Q8IUR5 | protein_coding | deleterious(0.02) | possibly_damaging(0.804) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMTC1 | SNV | Missense_Mutation | c.1468N>T | p.Ala490Ser | p.A490S | Q8IUR5 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-73-4668-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | pemetrexed | PD | |
TMTC1 | SNV | Missense_Mutation | c.460C>T | p.His154Tyr | p.H154Y | Q8IUR5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-73-4670-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
TMTC1 | SNV | Missense_Mutation | rs745880933 | c.1790G>A | p.Arg597Gln | p.R597Q | Q8IUR5 | protein_coding | tolerated(0.22) | benign(0.082) | TCGA-75-5125-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD |
TMTC1 | SNV | Missense_Mutation | c.635N>T | p.Gly212Val | p.G212V | Q8IUR5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | |
TMTC1 | SNV | Missense_Mutation | novel | c.2093G>T | p.Arg698Leu | p.R698L | Q8IUR5 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
TMTC1 | SNV | Missense_Mutation | novel | c.1889N>T | p.Gly630Val | p.G630V | Q8IUR5 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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