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Gene: TAB3 |
Gene summary for TAB3 |
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Gene information | Species | Human | Gene symbol | TAB3 | Gene ID | 257397 |
Gene name | TGF-beta activated kinase 1 (MAP3K7) binding protein 3 | |
Gene Alias | MAP3K7IP3 | |
Cytomap | Xp21.2 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | Q8N5C8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
257397 | TAB3 | NAFLD1 | Human | Liver | NAFLD | 2.20e-04 | 4.42e-01 | -0.04 |
257397 | TAB3 | HCC1_Meng | Human | Liver | HCC | 1.53e-28 | -6.94e-02 | 0.0246 |
257397 | TAB3 | HCC2_Meng | Human | Liver | HCC | 5.63e-19 | -2.07e-02 | 0.0107 |
257397 | TAB3 | HCC2 | Human | Liver | HCC | 1.71e-02 | 3.26e+00 | 0.5341 |
257397 | TAB3 | S027 | Human | Liver | HCC | 3.90e-02 | 3.99e-01 | 0.2446 |
257397 | TAB3 | S028 | Human | Liver | HCC | 1.12e-10 | 5.29e-01 | 0.2503 |
257397 | TAB3 | S029 | Human | Liver | HCC | 3.51e-13 | 7.04e-01 | 0.2581 |
257397 | TAB3 | HTA12-26-1 | Human | Pancreas | PDAC | 1.12e-06 | 5.01e-01 | 0.3728 |
257397 | TAB3 | HTA12-29-1 | Human | Pancreas | PDAC | 4.41e-22 | 5.68e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00098957 | Liver | NAFLD | negative regulation of catabolic process | 65/1882 | 320/18723 | 2.50e-08 | 2.71e-06 | 65 |
GO:00313307 | Liver | NAFLD | negative regulation of cellular catabolic process | 55/1882 | 262/18723 | 9.35e-08 | 7.59e-06 | 55 |
GO:00105065 | Liver | NAFLD | regulation of autophagy | 57/1882 | 317/18723 | 1.00e-05 | 3.18e-04 | 57 |
GO:001050621 | Liver | HCC | regulation of autophagy | 210/7958 | 317/18723 | 7.59e-18 | 8.45e-16 | 210 |
GO:000989522 | Liver | HCC | negative regulation of catabolic process | 196/7958 | 320/18723 | 7.98e-12 | 3.35e-10 | 196 |
GO:003133022 | Liver | HCC | negative regulation of cellular catabolic process | 164/7958 | 262/18723 | 3.52e-11 | 1.35e-09 | 164 |
GO:00105074 | Liver | HCC | negative regulation of autophagy | 57/7958 | 85/18723 | 4.10e-06 | 5.27e-05 | 57 |
GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
GO:004312312 | Liver | HCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 108/7958 | 186/18723 | 1.28e-05 | 1.43e-04 | 108 |
GO:004312212 | Liver | HCC | regulation of I-kappaB kinase/NF-kappaB signaling | 138/7958 | 249/18723 | 2.47e-05 | 2.58e-04 | 138 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513214 | Liver | NAFLD | Salmonella infection | 55/1043 | 249/8465 | 8.48e-06 | 3.09e-04 | 2.49e-04 | 55 |
hsa0513014 | Liver | NAFLD | Pathogenic Escherichia coli infection | 45/1043 | 197/8465 | 2.31e-05 | 6.88e-04 | 5.54e-04 | 45 |
hsa0513114 | Liver | NAFLD | Shigellosis | 48/1043 | 247/8465 | 7.82e-04 | 1.17e-02 | 9.39e-03 | 48 |
hsa0513215 | Liver | NAFLD | Salmonella infection | 55/1043 | 249/8465 | 8.48e-06 | 3.09e-04 | 2.49e-04 | 55 |
hsa0513015 | Liver | NAFLD | Pathogenic Escherichia coli infection | 45/1043 | 197/8465 | 2.31e-05 | 6.88e-04 | 5.54e-04 | 45 |
hsa0513115 | Liver | NAFLD | Shigellosis | 48/1043 | 247/8465 | 7.82e-04 | 1.17e-02 | 9.39e-03 | 48 |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513042 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0513142 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa049362 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa046684 | Liver | HCC | TNF signaling pathway | 73/4020 | 114/8465 | 2.53e-04 | 1.19e-03 | 6.63e-04 | 73 |
hsa0513252 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513052 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0513152 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa049363 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa0466811 | Liver | HCC | TNF signaling pathway | 73/4020 | 114/8465 | 2.53e-04 | 1.19e-03 | 6.63e-04 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAB3 | SNV | Missense_Mutation | c.121N>A | p.Ala41Thr | p.A41T | Q8N5C8 | protein_coding | deleterious(0.04) | possibly_damaging(0.813) | TCGA-22-5480-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD | |
TAB3 | SNV | Missense_Mutation | novel | c.2045N>G | p.Tyr682Cys | p.Y682C | Q8N5C8 | protein_coding | tolerated(0.06) | possibly_damaging(0.641) | TCGA-22-5481-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TAB3 | SNV | Missense_Mutation | c.1046C>T | p.Ala349Val | p.A349V | Q8N5C8 | protein_coding | tolerated(0.42) | benign(0.131) | TCGA-33-AASD-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TAB3 | SNV | Missense_Mutation | novel | c.1237N>T | p.Gly413Trp | p.G413W | Q8N5C8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TAB3 | SNV | Missense_Mutation | novel | c.1746A>T | p.Arg582Ser | p.R582S | Q8N5C8 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-39-5011-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
TAB3 | SNV | Missense_Mutation | novel | c.1229N>T | p.Pro410Leu | p.P410L | Q8N5C8 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-43-A475-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
TAB3 | SNV | Missense_Mutation | novel | c.104A>T | p.Asn35Ile | p.N35I | Q8N5C8 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TAB3 | SNV | Missense_Mutation | novel | c.934C>G | p.Gln312Glu | p.Q312E | Q8N5C8 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-56-8629-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
TAB3 | SNV | Missense_Mutation | c.701N>G | p.Gln234Arg | p.Q234R | Q8N5C8 | protein_coding | tolerated(0.35) | benign(0.306) | TCGA-60-2708-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
TAB3 | SNV | Missense_Mutation | novel | c.1238N>T | p.Gly413Val | p.G413V | Q8N5C8 | protein_coding | deleterious(0.02) | possibly_damaging(0.899) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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