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Gene: SUPT6H |
Gene summary for SUPT6H |
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Gene information | Species | Human | Gene symbol | SUPT6H | Gene ID | 6830 |
Gene name | SPT6 homolog, histone chaperone and transcription elongation factor | |
Gene Alias | SPT6 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q7KZ85 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6830 | SUPT6H | LZE2T | Human | Esophagus | ESCC | 8.79e-03 | 4.97e-01 | 0.082 |
6830 | SUPT6H | LZE4T | Human | Esophagus | ESCC | 1.33e-14 | 5.34e-01 | 0.0811 |
6830 | SUPT6H | LZE7T | Human | Esophagus | ESCC | 1.37e-08 | 4.81e-01 | 0.0667 |
6830 | SUPT6H | LZE8T | Human | Esophagus | ESCC | 4.07e-08 | 3.14e-01 | 0.067 |
6830 | SUPT6H | LZE20T | Human | Esophagus | ESCC | 1.88e-10 | 1.91e-01 | 0.0662 |
6830 | SUPT6H | LZE22T | Human | Esophagus | ESCC | 3.39e-08 | 3.30e-01 | 0.068 |
6830 | SUPT6H | LZE24T | Human | Esophagus | ESCC | 2.17e-17 | 6.07e-01 | 0.0596 |
6830 | SUPT6H | LZE21T | Human | Esophagus | ESCC | 4.13e-03 | 5.81e-01 | 0.0655 |
6830 | SUPT6H | P1T-E | Human | Esophagus | ESCC | 3.03e-20 | 8.67e-01 | 0.0875 |
6830 | SUPT6H | P2T-E | Human | Esophagus | ESCC | 1.24e-21 | 6.03e-01 | 0.1177 |
6830 | SUPT6H | P4T-E | Human | Esophagus | ESCC | 2.44e-20 | 4.59e-01 | 0.1323 |
6830 | SUPT6H | P5T-E | Human | Esophagus | ESCC | 6.27e-08 | 2.35e-01 | 0.1327 |
6830 | SUPT6H | P8T-E | Human | Esophagus | ESCC | 1.64e-28 | 6.19e-01 | 0.0889 |
6830 | SUPT6H | P9T-E | Human | Esophagus | ESCC | 9.99e-16 | 3.41e-01 | 0.1131 |
6830 | SUPT6H | P10T-E | Human | Esophagus | ESCC | 5.42e-27 | 6.58e-01 | 0.116 |
6830 | SUPT6H | P11T-E | Human | Esophagus | ESCC | 1.35e-14 | 6.47e-01 | 0.1426 |
6830 | SUPT6H | P12T-E | Human | Esophagus | ESCC | 2.08e-23 | 4.97e-01 | 0.1122 |
6830 | SUPT6H | P15T-E | Human | Esophagus | ESCC | 2.08e-28 | 6.94e-01 | 0.1149 |
6830 | SUPT6H | P16T-E | Human | Esophagus | ESCC | 3.84e-19 | 3.65e-01 | 0.1153 |
6830 | SUPT6H | P17T-E | Human | Esophagus | ESCC | 4.73e-09 | 3.99e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:0050684110 | Esophagus | ESCC | regulation of mRNA processing | 109/8552 | 137/18723 | 3.51e-16 | 2.59e-14 | 109 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:0046822110 | Esophagus | ESCC | regulation of nucleocytoplasmic transport | 88/8552 | 106/18723 | 1.88e-15 | 1.19e-13 | 88 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:007116612 | Esophagus | ESCC | ribonucleoprotein complex localization | 66/8552 | 77/18723 | 2.94e-13 | 1.38e-11 | 66 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUPT6H | SNV | Missense_Mutation | c.22N>A | p.Glu8Lys | p.E8K | Q7KZ85 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.905) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
SUPT6H | SNV | Missense_Mutation | c.950N>G | p.Ala317Gly | p.A317G | Q7KZ85 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-86-6562-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | vinblastine | PD | |
SUPT6H | SNV | Missense_Mutation | c.3540N>T | p.Gln1180His | p.Q1180H | Q7KZ85 | protein_coding | deleterious(0.05) | benign(0.142) | TCGA-86-A456-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SUPT6H | SNV | Missense_Mutation | novel | c.2477G>T | p.Arg826Leu | p.R826L | Q7KZ85 | protein_coding | deleterious(0.02) | benign(0.112) | TCGA-91-6847-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SUPT6H | SNV | Missense_Mutation | c.3183G>C | p.Glu1061Asp | p.E1061D | Q7KZ85 | protein_coding | deleterious(0.01) | probably_damaging(0.949) | TCGA-91-6847-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SUPT6H | SNV | Missense_Mutation | novel | c.1600N>T | p.Gly534Cys | p.G534C | Q7KZ85 | protein_coding | deleterious(0) | benign(0.366) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SUPT6H | SNV | Missense_Mutation | c.1891N>A | p.Ala631Thr | p.A631T | Q7KZ85 | protein_coding | tolerated(0.44) | benign(0.011) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SUPT6H | SNV | Missense_Mutation | novel | c.4994N>G | p.Lys1665Arg | p.K1665R | Q7KZ85 | protein_coding | tolerated(0.51) | benign(0.015) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
SUPT6H | SNV | Missense_Mutation | novel | c.7N>A | p.Asp3Asn | p.D3N | Q7KZ85 | protein_coding | deleterious_low_confidence(0) | benign(0.086) | TCGA-56-A5DS-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUPT6H | SNV | Missense_Mutation | novel | c.3527N>T | p.His1176Leu | p.H1176L | Q7KZ85 | protein_coding | deleterious(0.04) | benign(0.297) | TCGA-63-7021-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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