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Gene: SRRT |
Gene summary for SRRT |
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Gene information | Species | Human | Gene symbol | SRRT | Gene ID | 51593 |
Gene name | serrate, RNA effector molecule | |
Gene Alias | ARS2 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BXP5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51593 | SRRT | LZE4T | Human | Esophagus | ESCC | 1.17e-09 | 3.78e-01 | 0.0811 |
51593 | SRRT | LZE7T | Human | Esophagus | ESCC | 8.00e-14 | 7.79e-01 | 0.0667 |
51593 | SRRT | LZE8T | Human | Esophagus | ESCC | 9.28e-14 | 2.57e-01 | 0.067 |
51593 | SRRT | LZE20T | Human | Esophagus | ESCC | 3.37e-04 | 1.84e-01 | 0.0662 |
51593 | SRRT | LZE21D1 | Human | Esophagus | HGIN | 9.57e-03 | 2.26e-01 | 0.0632 |
51593 | SRRT | LZE22T | Human | Esophagus | ESCC | 1.27e-18 | 5.90e-01 | 0.068 |
51593 | SRRT | LZE24T | Human | Esophagus | ESCC | 4.12e-19 | 4.91e-01 | 0.0596 |
51593 | SRRT | LZE21T | Human | Esophagus | ESCC | 1.33e-03 | 5.75e-01 | 0.0655 |
51593 | SRRT | LZE6T | Human | Esophagus | ESCC | 1.63e-07 | 4.23e-01 | 0.0845 |
51593 | SRRT | P1T-E | Human | Esophagus | ESCC | 1.02e-14 | 7.65e-01 | 0.0875 |
51593 | SRRT | P2T-E | Human | Esophagus | ESCC | 2.48e-61 | 1.15e+00 | 0.1177 |
51593 | SRRT | P4T-E | Human | Esophagus | ESCC | 5.65e-23 | 6.35e-01 | 0.1323 |
51593 | SRRT | P5T-E | Human | Esophagus | ESCC | 6.72e-15 | 3.62e-01 | 0.1327 |
51593 | SRRT | P8T-E | Human | Esophagus | ESCC | 7.59e-29 | 6.05e-01 | 0.0889 |
51593 | SRRT | P9T-E | Human | Esophagus | ESCC | 1.55e-19 | 4.54e-01 | 0.1131 |
51593 | SRRT | P10T-E | Human | Esophagus | ESCC | 4.16e-30 | 6.51e-01 | 0.116 |
51593 | SRRT | P11T-E | Human | Esophagus | ESCC | 3.17e-16 | 6.20e-01 | 0.1426 |
51593 | SRRT | P12T-E | Human | Esophagus | ESCC | 1.13e-40 | 8.01e-01 | 0.1122 |
51593 | SRRT | P15T-E | Human | Esophagus | ESCC | 8.20e-33 | 8.48e-01 | 0.1149 |
51593 | SRRT | P16T-E | Human | Esophagus | ESCC | 3.37e-42 | 9.37e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00198277 | Esophagus | HGIN | stem cell population maintenance | 39/2587 | 131/18723 | 1.63e-06 | 6.14e-05 | 39 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:00987278 | Esophagus | HGIN | maintenance of cell number | 39/2587 | 134/18723 | 3.02e-06 | 1.03e-04 | 39 |
GO:00466859 | Esophagus | HGIN | response to arsenic-containing substance | 15/2587 | 33/18723 | 1.08e-05 | 3.10e-04 | 15 |
GO:00310532 | Esophagus | HGIN | primary miRNA processing | 6/2587 | 13/18723 | 4.97e-03 | 4.18e-02 | 6 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:004668514 | Esophagus | ESCC | response to arsenic-containing substance | 30/8552 | 33/18723 | 5.73e-08 | 1.02e-06 | 30 |
GO:009872714 | Esophagus | ESCC | maintenance of cell number | 90/8552 | 134/18723 | 3.94e-07 | 5.43e-06 | 90 |
GO:001982714 | Esophagus | ESCC | stem cell population maintenance | 88/8552 | 131/18723 | 5.23e-07 | 6.97e-06 | 88 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00507697 | Esophagus | ESCC | positive regulation of neurogenesis | 131/8552 | 225/18723 | 9.71e-05 | 6.90e-04 | 131 |
GO:00351969 | Esophagus | ESCC | production of miRNAs involved in gene silencing by miRNA | 37/8552 | 52/18723 | 1.75e-04 | 1.14e-03 | 37 |
GO:00310508 | Esophagus | ESCC | dsRNA processing | 38/8552 | 54/18723 | 2.08e-04 | 1.31e-03 | 38 |
GO:00709188 | Esophagus | ESCC | production of small RNA involved in gene silencing by RNA | 38/8552 | 54/18723 | 2.08e-04 | 1.31e-03 | 38 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:003105311 | Esophagus | ESCC | primary miRNA processing | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRRT | SNV | Missense_Mutation | novel | c.515N>G | p.Tyr172Cys | p.Y172C | Q9BXP5 | protein_coding | deleterious(0) | benign(0.108) | TCGA-CR-7383-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PR |
SRRT | SNV | Missense_Mutation | c.1358C>T | p.Ser453Leu | p.S453L | Q9BXP5 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-CV-7247-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
SRRT | SNV | Missense_Mutation | rs751168051 | c.1563N>G | p.Ile521Met | p.I521M | Q9BXP5 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-CX-7085-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SRRT | SNV | Missense_Mutation | novel | c.281N>C | p.Ser94Thr | p.S94T | Q9BXP5 | protein_coding | tolerated(0.39) | benign(0.099) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
SRRT | deletion | In_Frame_Del | novel | c.40_63delNNNNNNNNNNNNNNNNNNNNNNNN | p.Lys15_Asp22del | p.K15_D22del | Q9BXP5 | protein_coding | TCGA-CN-6012-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | ||
SRRT | insertion | In_Frame_Ins | novel | c.2203_2204insTCCCAC | p.Lys735delinsIleProGln | p.K735delinsIPQ | Q9BXP5 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
SRRT | SNV | Missense_Mutation | novel | c.1349N>C | p.Val450Ala | p.V450A | Q9BXP5 | protein_coding | tolerated(0.05) | probably_damaging(0.956) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SRRT | SNV | Missense_Mutation | c.2441N>A | p.Arg814His | p.R814H | Q9BXP5 | protein_coding | tolerated(0.45) | benign(0) | TCGA-CD-8530-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | CR | |
SRRT | SNV | Missense_Mutation | c.1507N>T | p.Arg503Cys | p.R503C | Q9BXP5 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
SRRT | SNV | Missense_Mutation | c.950N>G | p.Asn317Ser | p.N317S | Q9BXP5 | protein_coding | tolerated(0.83) | benign(0) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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