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Gene: SNX19 |
Gene summary for SNX19 |
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Gene information | Species | Human | Gene symbol | SNX19 | Gene ID | 399979 |
Gene name | sorting nexin 19 | |
Gene Alias | CHET8 | |
Cytomap | 11q24.3-q25 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | B7ZAU9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
399979 | SNX19 | C04 | Human | Oral cavity | OSCC | 8.34e-15 | 6.01e-01 | 0.2633 |
399979 | SNX19 | C21 | Human | Oral cavity | OSCC | 1.22e-03 | 2.18e-01 | 0.2678 |
399979 | SNX19 | C30 | Human | Oral cavity | OSCC | 1.13e-18 | 7.23e-01 | 0.3055 |
399979 | SNX19 | C51 | Human | Oral cavity | OSCC | 6.39e-03 | 2.01e-01 | 0.2674 |
399979 | SNX19 | SYSMH1 | Human | Oral cavity | OSCC | 1.71e-07 | 2.08e-01 | 0.1127 |
399979 | SNX19 | SYSMH2 | Human | Oral cavity | OSCC | 1.39e-03 | 1.90e-01 | 0.2326 |
399979 | SNX19 | SYSMH3 | Human | Oral cavity | OSCC | 1.30e-07 | 2.21e-01 | 0.2442 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160508 | Oral cavity | OSCC | vesicle organization | 189/7305 | 300/18723 | 2.40e-17 | 2.14e-15 | 189 |
GO:000930610 | Oral cavity | OSCC | protein secretion | 169/7305 | 359/18723 | 1.04e-03 | 5.34e-03 | 169 |
GO:003559210 | Oral cavity | OSCC | establishment of protein localization to extracellular region | 169/7305 | 360/18723 | 1.21e-03 | 6.08e-03 | 169 |
GO:00716929 | Oral cavity | OSCC | protein localization to extracellular region | 172/7305 | 368/18723 | 1.40e-03 | 6.79e-03 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX19 | SNV | Missense_Mutation | novel | c.1172G>A | p.Gly391Asp | p.G391D | Q92543 | protein_coding | tolerated(0.29) | benign(0.015) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SNX19 | SNV | Missense_Mutation | novel | c.2923N>T | p.Thr975Ser | p.T975S | Q92543 | protein_coding | tolerated(0.3) | benign(0.006) | TCGA-3M-AB46-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | CR |
SNX19 | SNV | Missense_Mutation | novel | c.487G>T | p.Gly163Cys | p.G163C | Q92543 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNX19 | SNV | Missense_Mutation | c.355C>T | p.Arg119Cys | p.R119C | Q92543 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SNX19 | SNV | Missense_Mutation | c.1549N>G | p.Ser517Gly | p.S517G | Q92543 | protein_coding | deleterious(0.04) | benign(0.265) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SNX19 | SNV | Missense_Mutation | rs769982884 | c.2674A>G | p.Lys892Glu | p.K892E | Q92543 | protein_coding | tolerated(0.47) | benign(0.007) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
SNX19 | SNV | Missense_Mutation | novel | c.1612N>G | p.Thr538Ala | p.T538A | Q92543 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SNX19 | SNV | Missense_Mutation | rs181345241 | c.581G>A | p.Arg194Gln | p.R194Q | Q92543 | protein_coding | tolerated(0.64) | benign(0) | TCGA-EM-A3SY-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SNX19 | SNV | Missense_Mutation | novel | c.2662G>C | p.Gly888Arg | p.G888R | Q92543 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
SNX19 | deletion | In_Frame_Del | novel | c.2063_2071delNNNNNNNNN | p.Leu688_Ala691delinsSer | p.L688_A691delinsS | Q92543 | protein_coding | TCGA-ET-A40S-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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