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Gene: SEMA3A |
Gene summary for SEMA3A |
Gene summary. |
Gene information | Species | Human | Gene symbol | SEMA3A | Gene ID | 10371 |
Gene name | semaphorin 3A | |
Gene Alias | COLL1 | |
Cytomap | 7q21.11 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q14563 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10371 | SEMA3A | HCC1_Meng | Human | Liver | HCC | 2.39e-13 | 3.90e-02 | 0.0246 |
10371 | SEMA3A | S014 | Human | Liver | HCC | 6.74e-18 | 6.26e-01 | 0.2254 |
10371 | SEMA3A | S015 | Human | Liver | HCC | 1.22e-03 | 3.01e-01 | 0.2375 |
10371 | SEMA3A | S016 | Human | Liver | HCC | 1.21e-14 | 5.02e-01 | 0.2243 |
10371 | SEMA3A | ATC09 | Human | Thyroid | ATC | 4.53e-07 | 4.02e-01 | 0.2871 |
10371 | SEMA3A | ATC11 | Human | Thyroid | ATC | 9.94e-09 | 9.03e-01 | 0.3386 |
10371 | SEMA3A | ATC12 | Human | Thyroid | ATC | 2.77e-07 | 1.93e-01 | 0.34 |
10371 | SEMA3A | ATC1 | Human | Thyroid | ATC | 2.63e-07 | 4.37e-01 | 0.2878 |
10371 | SEMA3A | ATC2 | Human | Thyroid | ATC | 7.49e-03 | 4.71e-01 | 0.34 |
10371 | SEMA3A | ATC3 | Human | Thyroid | ATC | 6.53e-05 | 2.95e-01 | 0.338 |
10371 | SEMA3A | ATC4 | Human | Thyroid | ATC | 6.40e-11 | 3.20e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:004873222 | Liver | HCC | gland development | 242/7958 | 436/18723 | 2.26e-08 | 5.28e-07 | 242 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
GO:2001224 | Liver | HCC | positive regulation of neuron migration | 14/7958 | 16/18723 | 2.73e-04 | 1.98e-03 | 14 |
GO:006056011 | Liver | HCC | developmental growth involved in morphogenesis | 124/7958 | 234/18723 | 7.37e-04 | 4.47e-03 | 124 |
GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:00459263 | Liver | HCC | negative regulation of growth | 129/7958 | 249/18723 | 1.81e-03 | 9.37e-03 | 129 |
GO:003287222 | Liver | HCC | regulation of stress-activated MAPK cascade | 102/7958 | 192/18723 | 1.86e-03 | 9.49e-03 | 102 |
GO:004867511 | Liver | HCC | axon extension | 67/7958 | 120/18723 | 2.17e-03 | 1.09e-02 | 67 |
GO:199013811 | Liver | HCC | neuron projection extension | 92/7958 | 172/18723 | 2.31e-03 | 1.14e-02 | 92 |
GO:004858811 | Liver | HCC | developmental cell growth | 121/7958 | 234/18723 | 2.68e-03 | 1.28e-02 | 121 |
GO:00507674 | Liver | HCC | regulation of neurogenesis | 181/7958 | 364/18723 | 3.00e-03 | 1.40e-02 | 181 |
GO:000725412 | Liver | HCC | JNK cascade | 89/7958 | 167/18723 | 3.09e-03 | 1.44e-02 | 89 |
GO:00083614 | Liver | HCC | regulation of cell size | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
GO:0030308 | Liver | HCC | negative regulation of cell growth | 98/7958 | 188/18723 | 4.74e-03 | 2.02e-02 | 98 |
GO:00305164 | Liver | HCC | regulation of axon extension | 52/7958 | 95/18723 | 1.07e-02 | 3.97e-02 | 52 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | CRC | AD |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | CRC | ADJ |
SEMA3A | NRP1_PLXNA4 | SEMA3A_NRP1_PLXNA4 | SEMA3 | CRC | ADJ |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | CRC | CRC |
SEMA3A | NRP1_PLXNA4 | SEMA3A_NRP1_PLXNA4 | SEMA3 | CRC | CRC |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | CRC | FAP |
SEMA3A | NRP1_PLXNA4 | SEMA3A_NRP1_PLXNA4 | SEMA3 | CRC | FAP |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | CRC | MSS |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | Endometrium | ADJ |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | Endometrium | AEH |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | Endometrium | EEC |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | Esophagus | ESCC |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | GC | ADJ |
SEMA3A | NRP1_PLXNA1 | SEMA3A_NRP1_PLXNA1 | SEMA3 | HNSCC | OSCC |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | HNSCC | OSCC |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | HNSCC | Precancer |
SEMA3A | NRP1_PLXNA4 | SEMA3A_NRP1_PLXNA4 | SEMA3 | Lung | AAH |
SEMA3A | NRP1_PLXNA4 | SEMA3A_NRP1_PLXNA4 | SEMA3 | Lung | ADJ |
SEMA3A | NRP1_PLXNA2 | SEMA3A_NRP1_PLXNA2 | SEMA3 | Lung | AIS |
SEMA3A | NRP1_PLXNA4 | SEMA3A_NRP1_PLXNA4 | SEMA3 | Lung | AIS |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEMA3A | SNV | Missense_Mutation | novel | c.1578G>T | p.Glu526Asp | p.E526D | Q14563 | protein_coding | tolerated(0.51) | probably_damaging(0.979) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
SEMA3A | SNV | Missense_Mutation | c.1226N>A | p.Met409Lys | p.M409K | Q14563 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4TC-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
SEMA3A | SNV | Missense_Mutation | c.1354G>A | p.Gly452Arg | p.G452R | Q14563 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SEMA3A | SNV | Missense_Mutation | c.1189N>A | p.Asp397Asn | p.D397N | Q14563 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
SEMA3A | SNV | Missense_Mutation | c.2054N>T | p.Gly685Val | p.G685V | Q14563 | protein_coding | tolerated(0.3) | benign(0) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SEMA3A | SNV | Missense_Mutation | c.1517C>A | p.Thr506Lys | p.T506K | Q14563 | protein_coding | tolerated(0.64) | benign(0) | TCGA-39-5036-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SEMA3A | SNV | Missense_Mutation | novel | c.2241N>T | p.Trp747Cys | p.W747C | Q14563 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SEMA3A | SNV | Missense_Mutation | novel | c.2240N>T | p.Trp747Leu | p.W747L | Q14563 | protein_coding | tolerated(0.15) | possibly_damaging(0.459) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SEMA3A | SNV | Missense_Mutation | novel | c.634N>T | p.Arg212Trp | p.R212W | Q14563 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-56-8308-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | SD |
SEMA3A | SNV | Missense_Mutation | rs566466269 | c.1811C>T | p.Ala604Val | p.A604V | Q14563 | protein_coding | deleterious(0.02) | benign(0.253) | TCGA-56-A4BW-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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