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Gene: SEC24C |
Gene summary for SEC24C |
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Gene information | Species | Human | Gene symbol | SEC24C | Gene ID | 9632 |
Gene name | SEC24 homolog C, COPII coat complex component | |
Gene Alias | SEC24C | |
Cytomap | 10q22.2 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | A0A024QZM6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9632 | SEC24C | LZE20T | Human | Esophagus | ESCC | 4.80e-02 | 3.98e-02 | 0.0662 |
9632 | SEC24C | LZE22T | Human | Esophagus | ESCC | 2.91e-05 | 2.83e-01 | 0.068 |
9632 | SEC24C | LZE24T | Human | Esophagus | ESCC | 6.68e-16 | 4.16e-01 | 0.0596 |
9632 | SEC24C | P1T-E | Human | Esophagus | ESCC | 1.62e-04 | 2.16e-01 | 0.0875 |
9632 | SEC24C | P2T-E | Human | Esophagus | ESCC | 2.71e-16 | 2.74e-01 | 0.1177 |
9632 | SEC24C | P4T-E | Human | Esophagus | ESCC | 3.71e-14 | 2.30e-01 | 0.1323 |
9632 | SEC24C | P5T-E | Human | Esophagus | ESCC | 6.11e-12 | 9.56e-02 | 0.1327 |
9632 | SEC24C | P8T-E | Human | Esophagus | ESCC | 2.69e-14 | 2.41e-01 | 0.0889 |
9632 | SEC24C | P10T-E | Human | Esophagus | ESCC | 1.37e-11 | 2.03e-01 | 0.116 |
9632 | SEC24C | P11T-E | Human | Esophagus | ESCC | 5.04e-07 | 1.86e-01 | 0.1426 |
9632 | SEC24C | P12T-E | Human | Esophagus | ESCC | 9.93e-15 | 3.17e-01 | 0.1122 |
9632 | SEC24C | P15T-E | Human | Esophagus | ESCC | 6.64e-16 | 2.82e-01 | 0.1149 |
9632 | SEC24C | P16T-E | Human | Esophagus | ESCC | 7.87e-15 | 2.89e-01 | 0.1153 |
9632 | SEC24C | P17T-E | Human | Esophagus | ESCC | 2.63e-08 | 3.08e-01 | 0.1278 |
9632 | SEC24C | P19T-E | Human | Esophagus | ESCC | 2.05e-06 | 3.84e-01 | 0.1662 |
9632 | SEC24C | P20T-E | Human | Esophagus | ESCC | 1.31e-09 | 2.28e-01 | 0.1124 |
9632 | SEC24C | P21T-E | Human | Esophagus | ESCC | 5.02e-20 | 4.37e-01 | 0.1617 |
9632 | SEC24C | P22T-E | Human | Esophagus | ESCC | 7.41e-06 | 1.02e-01 | 0.1236 |
9632 | SEC24C | P23T-E | Human | Esophagus | ESCC | 3.34e-15 | 3.09e-01 | 0.108 |
9632 | SEC24C | P24T-E | Human | Esophagus | ESCC | 1.75e-13 | 2.56e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:0006900111 | Esophagus | ESCC | vesicle budding from membrane | 54/8552 | 61/18723 | 2.66e-12 | 1.07e-10 | 54 |
GO:009011414 | Esophagus | ESCC | COPII-coated vesicle budding | 27/8552 | 29/18723 | 8.09e-08 | 1.39e-06 | 27 |
GO:00901104 | Esophagus | ESCC | COPII-coated vesicle cargo loading | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00354595 | Esophagus | ESCC | vesicle cargo loading | 19/8552 | 27/18723 | 8.35e-03 | 2.95e-02 | 19 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:000688821 | Liver | HCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 100/7958 | 130/18723 | 1.15e-15 | 8.67e-14 | 100 |
GO:001605021 | Liver | HCC | vesicle organization | 194/7958 | 300/18723 | 5.58e-15 | 3.97e-13 | 194 |
GO:000690021 | Liver | HCC | vesicle budding from membrane | 53/7958 | 61/18723 | 7.38e-13 | 3.80e-11 | 53 |
GO:00901142 | Liver | HCC | COPII-coated vesicle budding | 27/7958 | 29/18723 | 1.28e-08 | 3.14e-07 | 27 |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:00901102 | Liver | HCC | COPII-coated vesicle cargo loading | 14/7958 | 15/18723 | 5.65e-05 | 5.26e-04 | 14 |
GO:003545921 | Liver | HCC | vesicle cargo loading | 19/7958 | 27/18723 | 3.18e-03 | 1.47e-02 | 19 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00160508 | Oral cavity | OSCC | vesicle organization | 189/7305 | 300/18723 | 2.40e-17 | 2.14e-15 | 189 |
GO:00068888 | Oral cavity | OSCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 97/7305 | 130/18723 | 1.42e-16 | 1.15e-14 | 97 |
GO:000170116 | Oral cavity | OSCC | in utero embryonic development | 207/7305 | 367/18723 | 7.92e-12 | 2.95e-10 | 207 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa05130310 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0513042 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0513052 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa0513030 | Oral cavity | OSCC | Pathogenic Escherichia coli infection | 129/3704 | 197/8465 | 4.32e-10 | 5.17e-09 | 2.63e-09 | 129 |
hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa05130114 | Oral cavity | OSCC | Pathogenic Escherichia coli infection | 129/3704 | 197/8465 | 4.32e-10 | 5.17e-09 | 2.63e-09 | 129 |
hsa04141210 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
hsa05130210 | Oral cavity | LP | Pathogenic Escherichia coli infection | 87/2418 | 197/8465 | 1.71e-06 | 1.78e-05 | 1.15e-05 | 87 |
hsa0414138 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
hsa0513038 | Oral cavity | LP | Pathogenic Escherichia coli infection | 87/2418 | 197/8465 | 1.71e-06 | 1.78e-05 | 1.15e-05 | 87 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEC24C | deletion | Frame_Shift_Del | c.1369delN | p.Gln459SerfsTer32 | p.Q459Sfs*32 | P53992 | protein_coding | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |||
SEC24C | insertion | Frame_Shift_Ins | novel | c.1251_1252insG | p.Glu419GlyfsTer22 | p.E419Gfs*22 | P53992 | protein_coding | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | ||
SEC24C | insertion | Frame_Shift_Ins | rs764652839 | c.1368_1369insC | p.Gln459ProfsTer17 | p.Q459Pfs*17 | P53992 | protein_coding | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | ||
SEC24C | insertion | Frame_Shift_Ins | rs764652839 | c.1368_1369insC | p.Gln459ProfsTer17 | p.Q459Pfs*17 | P53992 | protein_coding | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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