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Gene: SCAF8 |
Gene summary for SCAF8 |
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Gene information | Species | Human | Gene symbol | SCAF8 | Gene ID | 22828 |
Gene name | SR-related CTD associated factor 8 | |
Gene Alias | RBM16 | |
Cytomap | 6q25.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A0A0MT33 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22828 | SCAF8 | CCI_1 | Human | Cervix | CC | 4.46e-02 | 4.49e-01 | 0.528 |
22828 | SCAF8 | CCI_2 | Human | Cervix | CC | 8.61e-09 | 7.49e-01 | 0.5249 |
22828 | SCAF8 | CCI_3 | Human | Cervix | CC | 2.93e-11 | 8.40e-01 | 0.516 |
22828 | SCAF8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.57e-06 | -3.54e-01 | 0.0155 |
22828 | SCAF8 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.48e-02 | 3.57e-01 | -0.1954 |
22828 | SCAF8 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.17e-03 | -3.78e-01 | 0.0674 |
22828 | SCAF8 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.56e-03 | 4.12e-01 | 0.294 |
22828 | SCAF8 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.99e-13 | -5.46e-01 | 0.3005 |
22828 | SCAF8 | A002-C-010 | Human | Colorectum | FAP | 1.36e-03 | -1.73e-01 | 0.242 |
22828 | SCAF8 | A015-C-203 | Human | Colorectum | FAP | 4.37e-28 | -5.43e-01 | -0.1294 |
22828 | SCAF8 | A015-C-204 | Human | Colorectum | FAP | 2.70e-07 | -4.14e-01 | -0.0228 |
22828 | SCAF8 | A014-C-040 | Human | Colorectum | FAP | 1.94e-08 | -7.48e-01 | -0.1184 |
22828 | SCAF8 | A002-C-201 | Human | Colorectum | FAP | 1.30e-15 | -4.27e-01 | 0.0324 |
22828 | SCAF8 | A002-C-203 | Human | Colorectum | FAP | 3.46e-04 | -2.53e-01 | 0.2786 |
22828 | SCAF8 | A001-C-119 | Human | Colorectum | FAP | 7.07e-12 | -5.93e-01 | -0.1557 |
22828 | SCAF8 | A001-C-108 | Human | Colorectum | FAP | 1.37e-16 | -4.15e-01 | -0.0272 |
22828 | SCAF8 | A002-C-205 | Human | Colorectum | FAP | 1.82e-28 | -6.35e-01 | -0.1236 |
22828 | SCAF8 | A001-C-104 | Human | Colorectum | FAP | 2.73e-05 | -3.54e-01 | 0.0184 |
22828 | SCAF8 | A015-C-005 | Human | Colorectum | FAP | 1.10e-04 | -3.22e-01 | -0.0336 |
22828 | SCAF8 | A015-C-006 | Human | Colorectum | FAP | 1.64e-18 | -5.65e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:00329847 | Cervix | CC | protein-containing complex disassembly | 41/2311 | 224/18723 | 6.13e-03 | 3.48e-02 | 41 |
GO:00063545 | Cervix | CC | DNA-templated transcription, elongation | 20/2311 | 91/18723 | 6.88e-03 | 3.74e-02 | 20 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0043244 | Colorectum | AD | regulation of protein-containing complex disassembly | 41/3918 | 121/18723 | 6.22e-04 | 6.48e-03 | 41 |
GO:0032786 | Colorectum | AD | positive regulation of DNA-templated transcription, elongation | 13/3918 | 27/18723 | 1.47e-03 | 1.25e-02 | 13 |
GO:0043242 | Colorectum | AD | negative regulation of protein-containing complex disassembly | 29/3918 | 82/18723 | 1.76e-03 | 1.45e-02 | 29 |
GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
GO:00063541 | Colorectum | MSS | DNA-templated transcription, elongation | 29/3467 | 91/18723 | 1.52e-03 | 1.39e-02 | 29 |
GO:00327861 | Colorectum | MSS | positive regulation of DNA-templated transcription, elongation | 12/3467 | 27/18723 | 1.74e-03 | 1.55e-02 | 12 |
GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
GO:00329844 | Colorectum | FAP | protein-containing complex disassembly | 54/2622 | 224/18723 | 3.37e-05 | 7.48e-04 | 54 |
GO:00327862 | Colorectum | FAP | positive regulation of DNA-templated transcription, elongation | 11/2622 | 27/18723 | 5.93e-04 | 6.58e-03 | 11 |
GO:00063542 | Colorectum | FAP | DNA-templated transcription, elongation | 24/2622 | 91/18723 | 1.32e-03 | 1.22e-02 | 24 |
GO:00432442 | Colorectum | FAP | regulation of protein-containing complex disassembly | 28/2622 | 121/18723 | 4.50e-03 | 3.06e-02 | 28 |
GO:00432421 | Colorectum | FAP | negative regulation of protein-containing complex disassembly | 20/2622 | 82/18723 | 8.23e-03 | 4.82e-02 | 20 |
GO:00329845 | Colorectum | CRC | protein-containing complex disassembly | 46/2078 | 224/18723 | 2.61e-05 | 7.18e-04 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCAF8 | SNV | Missense_Mutation | c.1873G>T | p.Ala625Ser | p.A625S | protein_coding | deleterious(0.04) | probably_damaging(0.975) | TCGA-44-7660-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Vaccine | recprame+as15 | PD | ||
SCAF8 | SNV | Missense_Mutation | c.3671N>G | p.His1224Arg | p.H1224R | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.958) | TCGA-44-A4SS-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SCAF8 | SNV | Missense_Mutation | novel | c.312N>A | p.Met104Ile | p.M104I | protein_coding | tolerated(0.11) | probably_damaging(0.963) | TCGA-49-6761-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SCAF8 | SNV | Missense_Mutation | novel | c.544N>T | p.Gly182Trp | p.G182W | protein_coding | deleterious(0.02) | probably_damaging(0.97) | TCGA-49-6761-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SCAF8 | SNV | Missense_Mutation | novel | c.1769N>T | p.Arg590Leu | p.R590L | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SCAF8 | SNV | Missense_Mutation | novel | c.2174C>T | p.Pro725Leu | p.P725L | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SCAF8 | SNV | Missense_Mutation | c.967G>T | p.Ala323Ser | p.A323S | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SCAF8 | SNV | Missense_Mutation | c.2671N>G | p.Leu891Val | p.L891V | protein_coding | tolerated_low_confidence(0.19) | probably_damaging(0.997) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | ||
SCAF8 | SNV | Missense_Mutation | novel | c.777G>C | p.Gln259His | p.Q259H | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-86-7711-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SCAF8 | SNV | Missense_Mutation | novel | c.1766N>T | p.Pro589Leu | p.P589L | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-34-5241-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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