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Gene: RUNX1T1 |
Gene summary for RUNX1T1 |
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Gene information | Species | Human | Gene symbol | RUNX1T1 | Gene ID | 862 |
Gene name | RUNX1 partner transcriptional co-repressor 1 | |
Gene Alias | AML1-MTG8 | |
Cytomap | 8q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B2R6I9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
862 | RUNX1T1 | HTA12-15-2 | Human | Pancreas | PDAC | 4.41e-04 | 3.66e-01 | 0.2315 |
862 | RUNX1T1 | HTA12-23-1 | Human | Pancreas | PDAC | 2.91e-17 | 1.17e+00 | 0.3405 |
862 | RUNX1T1 | HTA12-25-1 | Human | Pancreas | PDAC | 1.68e-12 | 8.37e-01 | 0.313 |
862 | RUNX1T1 | HTA12-26-1 | Human | Pancreas | PDAC | 1.81e-32 | 1.15e+00 | 0.3728 |
862 | RUNX1T1 | HTA12-29-1 | Human | Pancreas | PDAC | 1.45e-57 | 1.09e+00 | 0.3722 |
862 | RUNX1T1 | HTA12-30-1 | Human | Pancreas | PDAC | 2.27e-04 | 9.49e-01 | 0.3671 |
862 | RUNX1T1 | HTA12-32-1 | Human | Pancreas | PDAC | 4.23e-05 | 9.52e-01 | 0.3624 |
862 | RUNX1T1 | ATC12 | Human | Thyroid | ATC | 6.70e-03 | 1.48e-01 | 0.34 |
862 | RUNX1T1 | ATC13 | Human | Thyroid | ATC | 1.32e-57 | 9.87e-01 | 0.34 |
862 | RUNX1T1 | ATC4 | Human | Thyroid | ATC | 1.56e-05 | 1.90e-01 | 0.34 |
862 | RUNX1T1 | ATC5 | Human | Thyroid | ATC | 1.19e-57 | 1.04e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004544423 | Thyroid | ATC | fat cell differentiation | 105/6293 | 229/18723 | 7.42e-05 | 5.62e-04 | 105 |
GO:004559822 | Thyroid | ATC | regulation of fat cell differentiation | 61/6293 | 139/18723 | 7.28e-03 | 2.86e-02 | 61 |
GO:0045599 | Thyroid | ATC | negative regulation of fat cell differentiation | 28/6293 | 56/18723 | 8.12e-03 | 3.13e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUNX1T1 | SNV | Missense_Mutation | c.1104N>G | p.His368Gln | p.H368Q | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-NI-A8LF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
RUNX1T1 | SNV | Missense_Mutation | c.690N>T | p.Glu230Asp | p.E230D | protein_coding | tolerated(0.11) | benign(0.009) | TCGA-RC-A7SK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
RUNX1T1 | SNV | Missense_Mutation | c.1544N>A | p.Val515Glu | p.V515E | protein_coding | deleterious(0.01) | possibly_damaging(0.772) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | ||
RUNX1T1 | SNV | Missense_Mutation | rs777917271 | c.1400N>A | p.Ser467Asn | p.S467N | protein_coding | tolerated(0.23) | benign(0.258) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
RUNX1T1 | SNV | Missense_Mutation | c.1562N>A | p.Thr521Lys | p.T521K | protein_coding | tolerated(0.34) | benign(0.246) | TCGA-05-4395-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
RUNX1T1 | SNV | Missense_Mutation | c.1474C>A | p.Leu492Ile | p.L492I | protein_coding | tolerated(0.44) | benign(0.26) | TCGA-05-4417-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RUNX1T1 | SNV | Missense_Mutation | novel | c.718G>T | p.Val240Phe | p.V240F | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD | |
RUNX1T1 | SNV | Missense_Mutation | c.1441N>C | p.Asp481His | p.D481H | protein_coding | tolerated(0.08) | probably_damaging(0.919) | TCGA-44-2657-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RUNX1T1 | SNV | Missense_Mutation | novel | c.1753N>A | p.Cys585Ser | p.C585S | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RUNX1T1 | SNV | Missense_Mutation | c.1429N>A | p.Pro477Thr | p.P477T | protein_coding | tolerated(0.07) | benign(0.075) | TCGA-44-6778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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