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Gene: RPS6KC1 |
Gene summary for RPS6KC1 |
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Gene information | Species | Human | Gene symbol | RPS6KC1 | Gene ID | 26750 |
Gene name | ribosomal protein S6 kinase C1 | |
Gene Alias | RPK118 | |
Cytomap | 1q32.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96S38 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26750 | RPS6KC1 | CCI_1 | Human | Cervix | CC | 4.83e-09 | 1.07e+00 | 0.528 |
26750 | RPS6KC1 | CCI_2 | Human | Cervix | CC | 3.31e-04 | 5.06e-01 | 0.5249 |
26750 | RPS6KC1 | CCI_3 | Human | Cervix | CC | 4.90e-11 | 8.15e-01 | 0.516 |
26750 | RPS6KC1 | LZE4T | Human | Esophagus | ESCC | 2.21e-08 | 3.07e-01 | 0.0811 |
26750 | RPS6KC1 | LZE7T | Human | Esophagus | ESCC | 2.67e-07 | 2.56e-01 | 0.0667 |
26750 | RPS6KC1 | LZE24T | Human | Esophagus | ESCC | 2.21e-05 | 1.39e-01 | 0.0596 |
26750 | RPS6KC1 | LZE21T | Human | Esophagus | ESCC | 4.27e-04 | 2.66e-01 | 0.0655 |
26750 | RPS6KC1 | P1T-E | Human | Esophagus | ESCC | 2.08e-02 | 1.93e-01 | 0.0875 |
26750 | RPS6KC1 | P2T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.65e-01 | 0.1177 |
26750 | RPS6KC1 | P4T-E | Human | Esophagus | ESCC | 8.30e-03 | 1.19e-01 | 0.1323 |
26750 | RPS6KC1 | P5T-E | Human | Esophagus | ESCC | 1.13e-10 | 2.24e-01 | 0.1327 |
26750 | RPS6KC1 | P8T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.01e-01 | 0.0889 |
26750 | RPS6KC1 | P9T-E | Human | Esophagus | ESCC | 1.01e-13 | 3.57e-01 | 0.1131 |
26750 | RPS6KC1 | P10T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.90e-01 | 0.116 |
26750 | RPS6KC1 | P11T-E | Human | Esophagus | ESCC | 1.85e-10 | 3.92e-01 | 0.1426 |
26750 | RPS6KC1 | P12T-E | Human | Esophagus | ESCC | 2.56e-16 | 2.94e-01 | 0.1122 |
26750 | RPS6KC1 | P15T-E | Human | Esophagus | ESCC | 9.37e-13 | 3.05e-01 | 0.1149 |
26750 | RPS6KC1 | P16T-E | Human | Esophagus | ESCC | 6.17e-12 | 3.50e-01 | 0.1153 |
26750 | RPS6KC1 | P17T-E | Human | Esophagus | ESCC | 1.36e-02 | 1.47e-01 | 0.1278 |
26750 | RPS6KC1 | P19T-E | Human | Esophagus | ESCC | 1.67e-04 | 3.35e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS6KC1 | SNV | Missense_Mutation | novel | c.2311N>A | p.Glu771Lys | p.E771K | Q96S38 | protein_coding | tolerated(0.74) | benign(0.001) | TCGA-52-7811-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RPS6KC1 | SNV | Missense_Mutation | rs777557634 | c.3073C>T | p.Arg1025Cys | p.R1025C | Q96S38 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-58-8392-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RPS6KC1 | SNV | Missense_Mutation | c.1306C>T | p.Pro436Ser | p.P436S | Q96S38 | protein_coding | tolerated(1) | benign(0) | TCGA-60-2710-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | pemetrexed | SD | |
RPS6KC1 | SNV | Missense_Mutation | c.2407N>C | p.Gly803Arg | p.G803R | Q96S38 | protein_coding | tolerated(0.1) | benign(0.027) | TCGA-63-5128-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
RPS6KC1 | SNV | Missense_Mutation | novel | c.3183N>T | p.Trp1061Cys | p.W1061C | Q96S38 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-NC-A5HL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RPS6KC1 | SNV | Missense_Mutation | novel | c.1835N>C | p.Leu612Pro | p.L612P | Q96S38 | protein_coding | deleterious(0.02) | possibly_damaging(0.453) | TCGA-NC-A5HR-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
RPS6KC1 | insertion | Frame_Shift_Ins | rs775247030 | c.3162_3163insT | p.Thr1057TyrfsTer22 | p.T1057Yfs*22 | Q96S38 | protein_coding | TCGA-50-5072-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD | ||
RPS6KC1 | insertion | Frame_Shift_Ins | novel | c.725_726insGCCTAGAAATATGATCACAATAGTAAACAGAT | p.Ala243ProfsTer11 | p.A243Pfs*11 | Q96S38 | protein_coding | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
RPS6KC1 | insertion | Frame_Shift_Ins | novel | c.258_259insT | p.Gly88TrpfsTer4 | p.G88Wfs*4 | Q96S38 | protein_coding | TCGA-37-4135-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
RPS6KC1 | SNV | Missense_Mutation | c.1228G>T | p.Gly410Cys | p.G410C | Q96S38 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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