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Gene: RBM25 |
Gene summary for RBM25 |
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Gene information | Species | Human | Gene symbol | RBM25 | Gene ID | 58517 |
Gene name | RNA binding motif protein 25 | |
Gene Alias | NET52 | |
Cytomap | 14q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P49756 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58517 | RBM25 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.82e-14 | -5.56e-01 | 0.0155 |
58517 | RBM25 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.24e-02 | -4.95e-01 | -0.1207 |
58517 | RBM25 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.05e-03 | -3.84e-01 | 0.096 |
58517 | RBM25 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.95e-02 | -5.07e-01 | 0.0588 |
58517 | RBM25 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.49e-06 | 8.72e-01 | 0.3487 |
58517 | RBM25 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.54e-05 | -4.07e-01 | 0.3859 |
58517 | RBM25 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.08e-03 | -5.85e-01 | 0.2585 |
58517 | RBM25 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.51e-03 | -3.95e-01 | 0.3005 |
58517 | RBM25 | F007 | Human | Colorectum | FAP | 8.87e-03 | -8.64e-02 | 0.1176 |
58517 | RBM25 | A001-C-207 | Human | Colorectum | FAP | 2.84e-04 | 7.35e-02 | 0.1278 |
58517 | RBM25 | A015-C-203 | Human | Colorectum | FAP | 1.88e-45 | 3.92e-01 | -0.1294 |
58517 | RBM25 | A015-C-204 | Human | Colorectum | FAP | 3.38e-12 | 2.81e-01 | -0.0228 |
58517 | RBM25 | A014-C-040 | Human | Colorectum | FAP | 1.53e-06 | 2.28e-01 | -0.1184 |
58517 | RBM25 | A002-C-201 | Human | Colorectum | FAP | 5.94e-20 | 2.57e-01 | 0.0324 |
58517 | RBM25 | A002-C-203 | Human | Colorectum | FAP | 2.62e-04 | 8.47e-03 | 0.2786 |
58517 | RBM25 | A001-C-119 | Human | Colorectum | FAP | 7.92e-55 | 9.73e-01 | -0.1557 |
58517 | RBM25 | A001-C-108 | Human | Colorectum | FAP | 5.64e-29 | 4.22e-01 | -0.0272 |
58517 | RBM25 | A002-C-021 | Human | Colorectum | FAP | 2.25e-04 | 3.12e-01 | 0.1171 |
58517 | RBM25 | A002-C-205 | Human | Colorectum | FAP | 3.53e-49 | 6.06e-01 | -0.1236 |
58517 | RBM25 | A014-C-108 | Human | Colorectum | FAP | 5.42e-11 | 5.18e-01 | -0.124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0043484 | Colorectum | AD | regulation of RNA splicing | 70/3918 | 148/18723 | 6.47e-13 | 1.16e-10 | 70 |
GO:0048024 | Colorectum | AD | regulation of mRNA splicing, via spliceosome | 50/3918 | 101/18723 | 1.62e-10 | 1.56e-08 | 50 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:0000380 | Colorectum | AD | alternative mRNA splicing, via spliceosome | 33/3918 | 77/18723 | 1.13e-05 | 2.55e-04 | 33 |
GO:0000381 | Colorectum | AD | regulation of alternative mRNA splicing, via spliceosome | 27/3918 | 60/18723 | 2.41e-05 | 4.66e-04 | 27 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:19033112 | Colorectum | MSS | regulation of mRNA metabolic process | 115/3467 | 288/18723 | 1.23e-17 | 6.41e-15 | 115 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:00434842 | Colorectum | MSS | regulation of RNA splicing | 66/3467 | 148/18723 | 2.44e-13 | 5.25e-11 | 66 |
GO:00506842 | Colorectum | MSS | regulation of mRNA processing | 57/3467 | 137/18723 | 2.88e-10 | 2.68e-08 | 57 |
GO:00480242 | Colorectum | MSS | regulation of mRNA splicing, via spliceosome | 46/3467 | 101/18723 | 4.20e-10 | 3.49e-08 | 46 |
GO:00003802 | Colorectum | MSS | alternative mRNA splicing, via spliceosome | 33/3467 | 77/18723 | 6.87e-07 | 2.48e-05 | 33 |
GO:00003812 | Colorectum | MSS | regulation of alternative mRNA splicing, via spliceosome | 26/3467 | 60/18723 | 8.01e-06 | 2.03e-04 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM25 | SNV | Missense_Mutation | c.1291N>T | p.Arg431Trp | p.R431W | P49756 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
RBM25 | SNV | Missense_Mutation | c.26N>A | p.Arg9His | p.R9H | P49756 | protein_coding | deleterious_low_confidence(0.02) | benign(0.198) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RBM25 | SNV | Missense_Mutation | c.795N>A | p.Asn265Lys | p.N265K | P49756 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RBM25 | SNV | Missense_Mutation | c.653A>C | p.Tyr218Ser | p.Y218S | P49756 | protein_coding | deleterious(0.05) | possibly_damaging(0.61) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
RBM25 | SNV | Missense_Mutation | c.548N>T | p.Ala183Val | p.A183V | P49756 | protein_coding | tolerated(0.22) | benign(0.05) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RBM25 | SNV | Missense_Mutation | c.259N>G | p.Thr87Ala | p.T87A | P49756 | protein_coding | deleterious(0.01) | possibly_damaging(0.899) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RBM25 | SNV | Missense_Mutation | c.425N>A | p.Arg142His | p.R142H | P49756 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RBM25 | SNV | Missense_Mutation | rs143840737 | c.199N>A | p.Ala67Thr | p.A67T | P49756 | protein_coding | tolerated(0.37) | benign(0.005) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RBM25 | SNV | Missense_Mutation | c.1324N>A | p.Glu442Lys | p.E442K | P49756 | protein_coding | deleterious(0.02) | probably_damaging(0.959) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
RBM25 | SNV | Missense_Mutation | rs757997180 | c.1292N>A | p.Arg431Gln | p.R431Q | P49756 | protein_coding | deleterious(0.03) | possibly_damaging(0.885) | TCGA-VQ-A8PJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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