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Gene: RALGAPB |
Gene summary for RALGAPB |
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Gene information | Species | Human | Gene symbol | RALGAPB | Gene ID | 57148 |
Gene name | Ral GTPase activating protein non-catalytic subunit beta | |
Gene Alias | KIAA1219 | |
Cytomap | 20q11.23 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q6MZJ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57148 | RALGAPB | LZE4T | Human | Esophagus | ESCC | 2.49e-06 | 1.96e-01 | 0.0811 |
57148 | RALGAPB | LZE5T | Human | Esophagus | ESCC | 1.35e-02 | 2.52e-01 | 0.0514 |
57148 | RALGAPB | LZE7T | Human | Esophagus | ESCC | 1.71e-05 | 2.99e-01 | 0.0667 |
57148 | RALGAPB | LZE8T | Human | Esophagus | ESCC | 5.09e-03 | 4.89e-02 | 0.067 |
57148 | RALGAPB | LZE20T | Human | Esophagus | ESCC | 6.06e-04 | 1.56e-01 | 0.0662 |
57148 | RALGAPB | LZE24T | Human | Esophagus | ESCC | 3.74e-22 | 6.15e-01 | 0.0596 |
57148 | RALGAPB | P1T-E | Human | Esophagus | ESCC | 4.37e-09 | 3.47e-01 | 0.0875 |
57148 | RALGAPB | P2T-E | Human | Esophagus | ESCC | 1.70e-20 | 2.87e-01 | 0.1177 |
57148 | RALGAPB | P4T-E | Human | Esophagus | ESCC | 1.75e-09 | 2.26e-01 | 0.1323 |
57148 | RALGAPB | P5T-E | Human | Esophagus | ESCC | 1.88e-19 | 1.16e-01 | 0.1327 |
57148 | RALGAPB | P8T-E | Human | Esophagus | ESCC | 3.41e-18 | 3.39e-01 | 0.0889 |
57148 | RALGAPB | P9T-E | Human | Esophagus | ESCC | 1.30e-08 | 1.05e-01 | 0.1131 |
57148 | RALGAPB | P10T-E | Human | Esophagus | ESCC | 1.67e-24 | 3.90e-01 | 0.116 |
57148 | RALGAPB | P11T-E | Human | Esophagus | ESCC | 1.94e-14 | 3.69e-01 | 0.1426 |
57148 | RALGAPB | P12T-E | Human | Esophagus | ESCC | 1.74e-18 | 3.92e-01 | 0.1122 |
57148 | RALGAPB | P15T-E | Human | Esophagus | ESCC | 1.16e-21 | 4.69e-01 | 0.1149 |
57148 | RALGAPB | P16T-E | Human | Esophagus | ESCC | 2.78e-19 | 3.62e-01 | 0.1153 |
57148 | RALGAPB | P17T-E | Human | Esophagus | ESCC | 1.61e-02 | 1.38e-01 | 0.1278 |
57148 | RALGAPB | P20T-E | Human | Esophagus | ESCC | 7.94e-12 | 2.41e-01 | 0.1124 |
57148 | RALGAPB | P21T-E | Human | Esophagus | ESCC | 1.72e-19 | 3.35e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:005105617 | Thyroid | PTC | regulation of small GTPase mediated signal transduction | 132/5968 | 302/18723 | 9.26e-06 | 1.04e-04 | 132 |
GO:004308718 | Thyroid | PTC | regulation of GTPase activity | 148/5968 | 348/18723 | 1.63e-05 | 1.71e-04 | 148 |
GO:004354714 | Thyroid | PTC | positive regulation of GTPase activity | 103/5968 | 255/18723 | 2.38e-03 | 1.25e-02 | 103 |
GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
GO:004354715 | Thyroid | ATC | positive regulation of GTPase activity | 106/6293 | 255/18723 | 4.58e-03 | 1.89e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RALGAPB | SNV | Missense_Mutation | novel | c.425T>C | p.Leu142Ser | p.L142S | Q86X10 | protein_coding | tolerated(0.05) | benign(0.178) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
RALGAPB | SNV | Missense_Mutation | novel | c.1859C>T | p.Ser620Phe | p.S620F | Q86X10 | protein_coding | deleterious(0) | possibly_damaging(0.735) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RALGAPB | SNV | Missense_Mutation | novel | c.3178G>A | p.Glu1060Lys | p.E1060K | Q86X10 | protein_coding | tolerated(0.2) | benign(0.228) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RALGAPB | SNV | Missense_Mutation | rs140936843 | c.2323C>T | p.Arg775Cys | p.R775C | Q86X10 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RALGAPB | SNV | Missense_Mutation | rs755240443 | c.2150N>A | p.Arg717His | p.R717H | Q86X10 | protein_coding | tolerated(0.17) | probably_damaging(0.989) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RALGAPB | SNV | Missense_Mutation | novel | c.1846A>C | p.Asn616His | p.N616H | Q86X10 | protein_coding | tolerated(0.6) | benign(0.006) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
RALGAPB | SNV | Missense_Mutation | rs374734373 | c.2734G>A | p.Ala912Thr | p.A912T | Q86X10 | protein_coding | tolerated(0.19) | probably_damaging(0.998) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RALGAPB | SNV | Missense_Mutation | novel | c.697G>C | p.Val233Leu | p.V233L | Q86X10 | protein_coding | tolerated(1) | probably_damaging(0.98) | TCGA-EY-A1GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
RALGAPB | insertion | Nonsense_Mutation | novel | c.633_634insAACTATAAGTTGATCATCTAGTT | p.Pro212AsnfsTer7 | p.P212Nfs*7 | Q86X10 | protein_coding | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD | ||
RALGAPB | insertion | Frame_Shift_Ins | rs756557178 | c.1142dupC | p.His382ThrfsTer2 | p.H382Tfs*2 | Q86X10 | protein_coding | TCGA-AX-A05Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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