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Gene: PUM2 |
Gene summary for PUM2 |
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Gene information | Species | Human | Gene symbol | PUM2 | Gene ID | 23369 |
Gene name | pumilio RNA binding family member 2 | |
Gene Alias | PUMH2 | |
Cytomap | 2p24.1 | |
Gene Type | protein-coding | GO ID | GO:0002221 | UniProtAcc | Q8TB72 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23369 | PUM2 | CCI_1 | Human | Cervix | CC | 5.47e-06 | 1.19e+00 | 0.528 |
23369 | PUM2 | CCI_2 | Human | Cervix | CC | 6.93e-18 | 1.64e+00 | 0.5249 |
23369 | PUM2 | CCI_3 | Human | Cervix | CC | 5.01e-14 | 1.07e+00 | 0.516 |
23369 | PUM2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.92e-41 | -8.66e-01 | 0.0155 |
23369 | PUM2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.68e-13 | -6.32e-01 | -0.1808 |
23369 | PUM2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.43e-03 | -6.95e-01 | 0.0216 |
23369 | PUM2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.84e-11 | -6.62e-01 | -0.1207 |
23369 | PUM2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.63e-08 | -5.97e-01 | -0.1526 |
23369 | PUM2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.91e-22 | -5.98e-01 | -0.1464 |
23369 | PUM2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.01e-10 | -4.80e-01 | -0.1001 |
23369 | PUM2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.55e-02 | -4.05e-01 | -0.059 |
23369 | PUM2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.31e-02 | -6.30e-01 | -0.1706 |
23369 | PUM2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.34e-08 | -7.74e-01 | -0.2061 |
23369 | PUM2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.64e-03 | -5.18e-01 | -0.1462 |
23369 | PUM2 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.20e-08 | -6.19e-01 | -0.0842 |
23369 | PUM2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.87e-11 | -7.21e-01 | -0.0179 |
23369 | PUM2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.28e-16 | -6.88e-01 | 0.096 |
23369 | PUM2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.81e-03 | -6.26e-01 | 0.0446 |
23369 | PUM2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.82e-06 | -7.07e-01 | 0.0528 |
23369 | PUM2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.96e-06 | -4.75e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00321035 | Cervix | CC | positive regulation of response to external stimulus | 95/2311 | 427/18723 | 5.44e-09 | 5.03e-07 | 95 |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:00064029 | Cervix | CC | mRNA catabolic process | 56/2311 | 232/18723 | 4.81e-07 | 1.83e-05 | 56 |
GO:19033119 | Cervix | CC | regulation of mRNA metabolic process | 64/2311 | 288/18723 | 1.71e-06 | 5.64e-05 | 64 |
GO:00305229 | Cervix | CC | intracellular receptor signaling pathway | 60/2311 | 265/18723 | 1.89e-06 | 5.97e-05 | 60 |
GO:00064019 | Cervix | CC | RNA catabolic process | 62/2311 | 278/18723 | 2.18e-06 | 6.56e-05 | 62 |
GO:00028315 | Cervix | CC | regulation of response to biotic stimulus | 67/2311 | 327/18723 | 1.79e-05 | 3.36e-04 | 67 |
GO:000641710 | Cervix | CC | regulation of translation | 89/2311 | 468/18723 | 1.86e-05 | 3.46e-04 | 89 |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00610139 | Cervix | CC | regulation of mRNA catabolic process | 38/2311 | 166/18723 | 1.07e-04 | 1.36e-03 | 38 |
GO:00022212 | Cervix | CC | pattern recognition receptor signaling pathway | 39/2311 | 172/18723 | 1.08e-04 | 1.38e-03 | 39 |
GO:00622073 | Cervix | CC | regulation of pattern recognition receptor signaling pathway | 27/2311 | 105/18723 | 1.37e-04 | 1.68e-03 | 27 |
GO:00027534 | Cervix | CC | cytoplasmic pattern recognition receptor signaling pathway | 18/2311 | 60/18723 | 2.26e-04 | 2.55e-03 | 18 |
GO:00467008 | Cervix | CC | heterocycle catabolic process | 80/2311 | 445/18723 | 3.23e-04 | 3.42e-03 | 80 |
GO:00346559 | Cervix | CC | nucleobase-containing compound catabolic process | 74/2311 | 407/18723 | 3.77e-04 | 3.88e-03 | 74 |
GO:00434889 | Cervix | CC | regulation of mRNA stability | 35/2311 | 158/18723 | 3.80e-04 | 3.89e-03 | 35 |
GO:00434879 | Cervix | CC | regulation of RNA stability | 36/2311 | 170/18723 | 7.72e-04 | 6.86e-03 | 36 |
GO:00442709 | Cervix | CC | cellular nitrogen compound catabolic process | 79/2311 | 451/18723 | 7.80e-04 | 6.91e-03 | 79 |
GO:00395292 | Cervix | CC | RIG-I signaling pathway | 10/2311 | 27/18723 | 9.25e-04 | 7.84e-03 | 10 |
GO:00028331 | Cervix | CC | positive regulation of response to biotic stimulus | 35/2311 | 168/18723 | 1.23e-03 | 9.87e-03 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501716 | Cervix | CC | Spinocerebellar ataxia | 35/1267 | 143/8465 | 1.77e-03 | 7.21e-03 | 4.26e-03 | 35 |
hsa0501717 | Cervix | CC | Spinocerebellar ataxia | 35/1267 | 143/8465 | 1.77e-03 | 7.21e-03 | 4.26e-03 | 35 |
hsa05017 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa050171 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa050172 | Colorectum | SER | Spinocerebellar ataxia | 46/1580 | 143/8465 | 6.78e-05 | 7.51e-04 | 5.45e-04 | 46 |
hsa050173 | Colorectum | SER | Spinocerebellar ataxia | 46/1580 | 143/8465 | 6.78e-05 | 7.51e-04 | 5.45e-04 | 46 |
hsa050174 | Colorectum | MSS | Spinocerebellar ataxia | 60/1875 | 143/8465 | 7.14e-08 | 1.26e-06 | 7.71e-07 | 60 |
hsa050175 | Colorectum | MSS | Spinocerebellar ataxia | 60/1875 | 143/8465 | 7.14e-08 | 1.26e-06 | 7.71e-07 | 60 |
hsa050178 | Colorectum | FAP | Spinocerebellar ataxia | 37/1404 | 143/8465 | 2.94e-03 | 1.29e-02 | 7.86e-03 | 37 |
hsa050179 | Colorectum | FAP | Spinocerebellar ataxia | 37/1404 | 143/8465 | 2.94e-03 | 1.29e-02 | 7.86e-03 | 37 |
hsa0501718 | Endometrium | AEH | Spinocerebellar ataxia | 43/1197 | 143/8465 | 5.92e-07 | 7.69e-06 | 5.63e-06 | 43 |
hsa0501719 | Endometrium | AEH | Spinocerebellar ataxia | 43/1197 | 143/8465 | 5.92e-07 | 7.69e-06 | 5.63e-06 | 43 |
hsa0501723 | Endometrium | EEC | Spinocerebellar ataxia | 43/1237 | 143/8465 | 1.46e-06 | 2.01e-05 | 1.50e-05 | 43 |
hsa0501733 | Endometrium | EEC | Spinocerebellar ataxia | 43/1237 | 143/8465 | 1.46e-06 | 2.01e-05 | 1.50e-05 | 43 |
hsa0501728 | Esophagus | ESCC | Spinocerebellar ataxia | 94/4205 | 143/8465 | 6.77e-05 | 2.90e-04 | 1.48e-04 | 94 |
hsa0501736 | Esophagus | ESCC | Spinocerebellar ataxia | 94/4205 | 143/8465 | 6.77e-05 | 2.90e-04 | 1.48e-04 | 94 |
hsa0501710 | Liver | Cirrhotic | Spinocerebellar ataxia | 66/2530 | 143/8465 | 2.58e-05 | 2.15e-04 | 1.32e-04 | 66 |
hsa0501711 | Liver | Cirrhotic | Spinocerebellar ataxia | 66/2530 | 143/8465 | 2.58e-05 | 2.15e-04 | 1.32e-04 | 66 |
hsa0501721 | Liver | HCC | Spinocerebellar ataxia | 92/4020 | 143/8465 | 3.20e-05 | 1.88e-04 | 1.04e-04 | 92 |
hsa0501731 | Liver | HCC | Spinocerebellar ataxia | 92/4020 | 143/8465 | 3.20e-05 | 1.88e-04 | 1.04e-04 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PUM2 | deletion | Frame_Shift_Del | novel | c.396delN | p.Gly133AlafsTer24 | p.G133Afs*24 | Q8TB72 | protein_coding | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | ||
PUM2 | SNV | Missense_Mutation | c.2074N>T | p.Pro692Ser | p.P692S | Q8TB72 | protein_coding | tolerated(0.51) | benign(0.02) | TCGA-BR-8286-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PUM2 | SNV | Missense_Mutation | c.2576N>C | p.Val859Ala | p.V859A | Q8TB72 | protein_coding | deleterious(0.03) | possibly_damaging(0.608) | TCGA-BR-A453-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PUM2 | SNV | Missense_Mutation | novel | c.829N>C | p.Thr277Pro | p.T277P | Q8TB72 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.97) | TCGA-D7-8572-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PUM2 | SNV | Missense_Mutation | c.1115N>G | p.Gln372Arg | p.Q372R | Q8TB72 | protein_coding | deleterious_low_confidence(0.02) | benign(0.209) | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PUM2 | SNV | Missense_Mutation | novel | c.2654N>A | p.Cys885Tyr | p.C885Y | Q8TB72 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IN-A6RL-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
PUM2 | SNV | Missense_Mutation | c.292N>A | p.Val98Ile | p.V98I | Q8TB72 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
PUM2 | deletion | Frame_Shift_Del | novel | c.396delN | p.Gly133AlafsTer24 | p.G133Afs*24 | Q8TB72 | protein_coding | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | ||
PUM2 | SNV | Missense_Mutation | novel | c.2138A>G | p.Asp713Gly | p.D713G | Q8TB72 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EL-A4K7-01 | Thyroid | thyroid carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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