![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PLCH1 |
Gene summary for PLCH1 |
![]() |
Gene information | Species | Human | Gene symbol | PLCH1 | Gene ID | 23007 |
Gene name | phospholipase C eta 1 | |
Gene Alias | PLC eta 1 | |
Cytomap | 3q25.31 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q4KWH8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23007 | PLCH1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.32e-12 | -5.10e-01 | 0.0155 |
23007 | PLCH1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.86e-08 | -6.23e-01 | -0.1207 |
23007 | PLCH1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.15e-04 | -4.02e-01 | 0.096 |
23007 | PLCH1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.97e-03 | -3.73e-01 | 0.0674 |
23007 | PLCH1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.31e-05 | -5.90e-01 | 0.2585 |
23007 | PLCH1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.09e-17 | -6.29e-01 | 0.3005 |
23007 | PLCH1 | A015-C-203 | Human | Colorectum | FAP | 2.02e-21 | -4.45e-01 | -0.1294 |
23007 | PLCH1 | A015-C-204 | Human | Colorectum | FAP | 2.43e-05 | -2.17e-01 | -0.0228 |
23007 | PLCH1 | A014-C-040 | Human | Colorectum | FAP | 2.92e-04 | -3.67e-01 | -0.1184 |
23007 | PLCH1 | A002-C-201 | Human | Colorectum | FAP | 2.70e-14 | -3.24e-01 | 0.0324 |
23007 | PLCH1 | A002-C-203 | Human | Colorectum | FAP | 1.61e-02 | 1.42e-01 | 0.2786 |
23007 | PLCH1 | A001-C-119 | Human | Colorectum | FAP | 7.53e-07 | -3.34e-01 | -0.1557 |
23007 | PLCH1 | A001-C-108 | Human | Colorectum | FAP | 1.94e-12 | -2.54e-01 | -0.0272 |
23007 | PLCH1 | A002-C-205 | Human | Colorectum | FAP | 6.46e-21 | -3.16e-01 | -0.1236 |
23007 | PLCH1 | A015-C-005 | Human | Colorectum | FAP | 3.13e-03 | -1.84e-01 | -0.0336 |
23007 | PLCH1 | A015-C-006 | Human | Colorectum | FAP | 1.89e-15 | -3.73e-01 | -0.0994 |
23007 | PLCH1 | A015-C-106 | Human | Colorectum | FAP | 4.02e-09 | -3.24e-01 | -0.0511 |
23007 | PLCH1 | A002-C-114 | Human | Colorectum | FAP | 4.22e-20 | -4.52e-01 | -0.1561 |
23007 | PLCH1 | A015-C-104 | Human | Colorectum | FAP | 1.32e-23 | -3.79e-01 | -0.1899 |
23007 | PLCH1 | A001-C-014 | Human | Colorectum | FAP | 4.21e-08 | -2.87e-01 | 0.0135 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0048017 | Colorectum | AD | inositol lipid-mediated signaling | 53/3918 | 182/18723 | 5.35e-03 | 3.52e-02 | 53 |
GO:0048015 | Colorectum | AD | phosphatidylinositol-mediated signaling | 52/3918 | 178/18723 | 5.37e-03 | 3.54e-02 | 52 |
GO:00160422 | Colorectum | MSS | lipid catabolic process | 77/3467 | 320/18723 | 7.43e-03 | 4.71e-02 | 77 |
GO:00160423 | Colorectum | FAP | lipid catabolic process | 65/2622 | 320/18723 | 1.13e-03 | 1.08e-02 | 65 |
GO:00160424 | Colorectum | CRC | lipid catabolic process | 53/2078 | 320/18723 | 1.89e-03 | 1.93e-02 | 53 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00562 | Colorectum | CRC | Inositol phosphate metabolism | 18/1091 | 73/8465 | 4.38e-03 | 2.52e-02 | 1.71e-02 | 18 |
hsa005621 | Colorectum | CRC | Inositol phosphate metabolism | 18/1091 | 73/8465 | 4.38e-03 | 2.52e-02 | 1.71e-02 | 18 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLCH1 | SNV | Missense_Mutation | c.4105N>A | p.Leu1369Ile | p.L1369I | Q4KWH8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.991) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
PLCH1 | SNV | Missense_Mutation | novel | c.961N>A | p.Asp321Asn | p.D321N | Q4KWH8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
PLCH1 | SNV | Missense_Mutation | rs374607347 | c.143N>A | p.Arg48Gln | p.R48Q | Q4KWH8 | protein_coding | deleterious(0.01) | possibly_damaging(0.638) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH1 | SNV | Missense_Mutation | rs780609556 | c.1982G>A | p.Arg661His | p.R661H | Q4KWH8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLCH1 | SNV | Missense_Mutation | novel | c.3739N>C | p.Ser1247Pro | p.S1247P | Q4KWH8 | protein_coding | tolerated_low_confidence(0.59) | benign(0) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
PLCH1 | SNV | Missense_Mutation | rs370205187 | c.155N>A | p.Arg52Gln | p.R52Q | Q4KWH8 | protein_coding | deleterious(0.03) | possibly_damaging(0.873) | TCGA-AX-A2H2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLCH1 | SNV | Missense_Mutation | novel | c.2852G>T | p.Arg951Ile | p.R951I | Q4KWH8 | protein_coding | deleterious(0.03) | possibly_damaging(0.646) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
PLCH1 | SNV | Missense_Mutation | rs760652400 | c.66G>A | p.Met22Ile | p.M22I | Q4KWH8 | protein_coding | deleterious(0) | possibly_damaging(0.826) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PLCH1 | SNV | Missense_Mutation | novel | c.448A>G | p.Thr150Ala | p.T150A | Q4KWH8 | protein_coding | deleterious(0) | possibly_damaging(0.796) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLCH1 | SNV | Missense_Mutation | rs745760948 | c.3145A>G | p.Met1049Val | p.M1049V | Q4KWH8 | protein_coding | tolerated_low_confidence(0.64) | benign(0) | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |