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Gene: PHF8 |
Gene summary for PHF8 |
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Gene information | Species | Human | Gene symbol | PHF8 | Gene ID | 23133 |
Gene name | PHD finger protein 8 | |
Gene Alias | JHDM1F | |
Cytomap | Xp11.22 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q9UPP1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23133 | PHF8 | LZE4T | Human | Esophagus | ESCC | 2.63e-02 | 4.92e-02 | 0.0811 |
23133 | PHF8 | LZE7T | Human | Esophagus | ESCC | 3.34e-03 | 3.43e-01 | 0.0667 |
23133 | PHF8 | LZE8T | Human | Esophagus | ESCC | 7.46e-03 | 9.55e-02 | 0.067 |
23133 | PHF8 | LZE24T | Human | Esophagus | ESCC | 5.69e-16 | 4.52e-01 | 0.0596 |
23133 | PHF8 | LZE21T | Human | Esophagus | ESCC | 2.71e-02 | 2.94e-01 | 0.0655 |
23133 | PHF8 | P1T-E | Human | Esophagus | ESCC | 1.60e-03 | 1.32e-01 | 0.0875 |
23133 | PHF8 | P2T-E | Human | Esophagus | ESCC | 3.34e-12 | 2.06e-01 | 0.1177 |
23133 | PHF8 | P4T-E | Human | Esophagus | ESCC | 3.63e-11 | 2.14e-01 | 0.1323 |
23133 | PHF8 | P5T-E | Human | Esophagus | ESCC | 9.70e-07 | 2.87e-02 | 0.1327 |
23133 | PHF8 | P8T-E | Human | Esophagus | ESCC | 9.76e-23 | 3.26e-01 | 0.0889 |
23133 | PHF8 | P9T-E | Human | Esophagus | ESCC | 5.30e-06 | 9.75e-02 | 0.1131 |
23133 | PHF8 | P10T-E | Human | Esophagus | ESCC | 3.41e-03 | 3.11e-02 | 0.116 |
23133 | PHF8 | P11T-E | Human | Esophagus | ESCC | 3.57e-05 | 1.65e-01 | 0.1426 |
23133 | PHF8 | P12T-E | Human | Esophagus | ESCC | 8.49e-13 | 3.32e-01 | 0.1122 |
23133 | PHF8 | P15T-E | Human | Esophagus | ESCC | 6.64e-09 | 2.07e-01 | 0.1149 |
23133 | PHF8 | P16T-E | Human | Esophagus | ESCC | 8.53e-18 | 2.04e-01 | 0.1153 |
23133 | PHF8 | P20T-E | Human | Esophagus | ESCC | 2.67e-07 | 1.84e-01 | 0.1124 |
23133 | PHF8 | P21T-E | Human | Esophagus | ESCC | 2.50e-07 | 4.45e-02 | 0.1617 |
23133 | PHF8 | P22T-E | Human | Esophagus | ESCC | 4.70e-13 | 1.66e-01 | 0.1236 |
23133 | PHF8 | P23T-E | Human | Esophagus | ESCC | 1.36e-11 | 3.04e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00400295 | Esophagus | ESCC | regulation of gene expression, epigenetic | 74/8552 | 105/18723 | 2.24e-07 | 3.42e-06 | 74 |
GO:000008214 | Esophagus | ESCC | G1/S transition of mitotic cell cycle | 134/8552 | 214/18723 | 4.04e-07 | 5.55e-06 | 134 |
GO:004484314 | Esophagus | ESCC | cell cycle G1/S phase transition | 148/8552 | 241/18723 | 5.68e-07 | 7.48e-06 | 148 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:00063564 | Esophagus | ESCC | regulation of transcription by RNA polymerase I | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:00459432 | Esophagus | ESCC | positive regulation of transcription by RNA polymerase I | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00064824 | Esophagus | ESCC | protein demethylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00082144 | Esophagus | ESCC | protein dealkylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00708281 | Esophagus | ESCC | heterochromatin organization | 31/8552 | 46/18723 | 2.42e-03 | 1.06e-02 | 31 |
GO:00165773 | Esophagus | ESCC | histone demethylation | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:00700763 | Esophagus | ESCC | histone lysine demethylation | 20/8552 | 28/18723 | 5.23e-03 | 1.97e-02 | 20 |
GO:0045814 | Esophagus | ESCC | negative regulation of gene expression, epigenetic | 32/8552 | 50/18723 | 6.90e-03 | 2.52e-02 | 32 |
GO:00609686 | Esophagus | ESCC | regulation of gene silencing | 48/8552 | 81/18723 | 9.54e-03 | 3.30e-02 | 48 |
GO:19022751 | Esophagus | ESCC | regulation of chromatin organization | 22/8552 | 33/18723 | 1.22e-02 | 4.08e-02 | 22 |
GO:00447727 | Prostate | BPH | mitotic cell cycle phase transition | 112/3107 | 424/18723 | 1.57e-07 | 3.58e-06 | 112 |
GO:00165706 | Prostate | BPH | histone modification | 120/3107 | 463/18723 | 1.73e-07 | 3.89e-06 | 120 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF8 | SNV | Missense_Mutation | novel | c.2188N>A | p.Leu730Met | p.L730M | Q9UPP1 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-05-4405-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHF8 | SNV | Missense_Mutation | c.1573N>A | p.Gly525Ser | p.G525S | Q9UPP1 | protein_coding | tolerated(0.74) | benign(0) | TCGA-05-5428-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
PHF8 | SNV | Missense_Mutation | novel | c.1063N>T | p.His355Tyr | p.H355Y | Q9UPP1 | protein_coding | tolerated(0.35) | possibly_damaging(0.645) | TCGA-44-3396-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | alimta | SD |
PHF8 | SNV | Missense_Mutation | rs782358977 | c.2453N>A | p.Arg818Gln | p.R818Q | Q9UPP1 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-44-A4SU-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PHF8 | SNV | Missense_Mutation | c.1351N>T | p.Asp451Tyr | p.D451Y | Q9UPP1 | protein_coding | deleterious(0) | benign(0.1) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
PHF8 | SNV | Missense_Mutation | rs782241612 | c.752G>T | p.Trp251Leu | p.W251L | Q9UPP1 | protein_coding | deleterious(0) | possibly_damaging(0.53) | TCGA-55-6978-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PHF8 | SNV | Missense_Mutation | c.2330N>G | p.Ser777Cys | p.S777C | Q9UPP1 | protein_coding | tolerated(0.05) | benign(0.022) | TCGA-55-7570-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PHF8 | SNV | Missense_Mutation | novel | c.47C>A | p.Pro16His | p.P16H | Q9UPP1 | protein_coding | deleterious_low_confidence(0) | benign(0.146) | TCGA-55-7911-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PHF8 | SNV | Missense_Mutation | novel | c.772G>C | p.Glu258Gln | p.E258Q | Q9UPP1 | protein_coding | deleterious(0.01) | benign(0.272) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PHF8 | SNV | Missense_Mutation | c.1625N>T | p.Arg542Leu | p.R542L | Q9UPP1 | protein_coding | deleterious(0.01) | benign(0.067) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23133 | PHF8 | ENZYME, DRUGGABLE GENOME | inhibitor | 178103604 |
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