![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PEG3 |
Gene summary for PEG3 |
![]() |
Gene information | Species | Human | Gene symbol | PEG3 | Gene ID | 5178 |
Gene name | paternally expressed 3 | |
Gene Alias | PW1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9GZU2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5178 | PEG3 | GSM4909281 | Human | Breast | IDC | 1.58e-28 | 5.45e-01 | 0.21 |
5178 | PEG3 | GSM4909298 | Human | Breast | IDC | 4.14e-61 | 8.98e-01 | 0.1551 |
5178 | PEG3 | GSM4909304 | Human | Breast | IDC | 5.34e-07 | 2.18e-01 | 0.1636 |
5178 | PEG3 | HCC1_Meng | Human | Liver | HCC | 8.95e-10 | 4.36e-02 | 0.0246 |
5178 | PEG3 | HCC2 | Human | Liver | HCC | 1.25e-22 | 3.74e+00 | 0.5341 |
5178 | PEG3 | S014 | Human | Liver | HCC | 2.68e-34 | 1.10e+00 | 0.2254 |
5178 | PEG3 | S015 | Human | Liver | HCC | 3.41e-32 | 1.14e+00 | 0.2375 |
5178 | PEG3 | S016 | Human | Liver | HCC | 4.77e-32 | 1.21e+00 | 0.2243 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PEG3 | PERI | Cervix | HSIL_HPV | AC006115.2,HES6,SERTM1, etc. | 3.67e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEG3 | SNV | Missense_Mutation | c.3658N>A | p.Leu1220Ile | p.L1220I | Q9GZU2 | protein_coding | tolerated(0.38) | benign(0.023) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PEG3 | SNV | Missense_Mutation | c.132N>G | p.Phe44Leu | p.F44L | Q9GZU2 | protein_coding | tolerated(0.07) | benign(0.048) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PEG3 | SNV | Missense_Mutation | novel | c.1157N>A | p.Arg386Lys | p.R386K | Q9GZU2 | protein_coding | tolerated(0.22) | benign(0.021) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | rs150561309 | c.4330G>A | p.Glu1444Lys | p.E1444K | Q9GZU2 | protein_coding | tolerated(0.07) | benign(0.118) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | novel | c.3844T>G | p.Phe1282Val | p.F1282V | Q9GZU2 | protein_coding | deleterious(0.02) | benign(0.248) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | novel | c.2967G>T | p.Lys989Asn | p.K989N | Q9GZU2 | protein_coding | tolerated(0.06) | probably_damaging(0.932) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | novel | c.1908C>A | p.Phe636Leu | p.F636L | Q9GZU2 | protein_coding | tolerated(0.08) | probably_damaging(0.987) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | novel | c.1802N>T | p.Glu601Val | p.E601V | Q9GZU2 | protein_coding | tolerated(0.14) | possibly_damaging(0.72) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
PEG3 | SNV | Missense_Mutation | novel | c.1195N>T | p.Asp399Tyr | p.D399Y | Q9GZU2 | protein_coding | deleterious(0) | possibly_damaging(0.751) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PEG3 | SNV | Missense_Mutation | novel | c.1574A>T | p.Lys525Met | p.K525M | Q9GZU2 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |