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Gene: PCNX2 |
Gene summary for PCNX2 |
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Gene information | Species | Human | Gene symbol | PCNX2 | Gene ID | 80003 |
Gene name | pecanex 2 | |
Gene Alias | PCNXL2 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A6NKB5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80003 | PCNX2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.46e-04 | 4.62e-01 | -0.0811 |
80003 | PCNX2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.50e-03 | 5.12e-01 | -0.059 |
80003 | PCNX2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.84e-03 | 4.34e-01 | 0.0131 |
80003 | PCNX2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.79e-02 | 1.91e-01 | 0.0674 |
80003 | PCNX2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.20e-07 | 5.98e-01 | 0.0588 |
80003 | PCNX2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.49e-03 | 1.41e-01 | 0.294 |
80003 | PCNX2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.87e-04 | 4.02e-01 | 0.281 |
80003 | PCNX2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.63e-05 | 2.21e-01 | 0.3005 |
80003 | PCNX2 | A002-C-010 | Human | Colorectum | FAP | 1.27e-03 | 3.89e-01 | 0.242 |
80003 | PCNX2 | A001-C-108 | Human | Colorectum | FAP | 1.02e-02 | 3.94e-01 | -0.0272 |
80003 | PCNX2 | A002-C-021 | Human | Colorectum | FAP | 4.72e-16 | 5.28e-01 | 0.1171 |
80003 | PCNX2 | A001-C-104 | Human | Colorectum | FAP | 1.30e-03 | 4.47e-01 | 0.0184 |
80003 | PCNX2 | A015-C-202 | Human | Colorectum | FAP | 4.97e-02 | 3.09e-01 | -0.0849 |
80003 | PCNX2 | A015-C-002 | Human | Colorectum | FAP | 2.96e-02 | 3.98e-01 | -0.0763 |
80003 | PCNX2 | A008-E-015 | Human | Colorectum | FAP | 1.74e-07 | 3.94e-01 | 0.0177 |
80003 | PCNX2 | AEH-subject1 | Human | Endometrium | AEH | 2.66e-23 | 4.00e-01 | -0.3059 |
80003 | PCNX2 | AEH-subject2 | Human | Endometrium | AEH | 1.07e-12 | 3.01e-01 | -0.2525 |
80003 | PCNX2 | AEH-subject3 | Human | Endometrium | AEH | 2.44e-20 | 4.33e-01 | -0.2576 |
80003 | PCNX2 | AEH-subject4 | Human | Endometrium | AEH | 1.17e-16 | 4.06e-01 | -0.2657 |
80003 | PCNX2 | AEH-subject5 | Human | Endometrium | AEH | 1.69e-11 | 2.43e-01 | -0.2953 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCNX2 | SNV | Missense_Mutation | rs373041734 | c.5923G>A | p.Glu1975Lys | p.E1975K | A6NKB5 | protein_coding | tolerated(0.73) | benign(0.169) | TCGA-D1-A0ZS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCNX2 | SNV | Missense_Mutation | c.194G>A | p.Ser65Asn | p.S65N | A6NKB5 | protein_coding | tolerated(0.16) | benign(0.069) | TCGA-D1-A0ZS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCNX2 | SNV | Missense_Mutation | rs779501694 | c.1754N>T | p.Ser585Phe | p.S585F | A6NKB5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCNX2 | SNV | Missense_Mutation | novel | c.4156N>G | p.Asn1386Asp | p.N1386D | A6NKB5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PCNX2 | SNV | Missense_Mutation | novel | c.3631N>G | p.Ile1211Val | p.I1211V | A6NKB5 | protein_coding | tolerated(0.38) | benign(0.223) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PCNX2 | SNV | Missense_Mutation | rs374424345 | c.6121N>A | p.Ala2041Thr | p.A2041T | A6NKB5 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-D1-A17D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
PCNX2 | SNV | Missense_Mutation | novel | c.2863G>T | p.Val955Leu | p.V955L | A6NKB5 | protein_coding | tolerated(0.11) | benign(0.055) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PCNX2 | SNV | Missense_Mutation | novel | c.5273N>G | p.Asp1758Gly | p.D1758G | A6NKB5 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PCNX2 | SNV | Missense_Mutation | c.1849N>A | p.Glu617Lys | p.E617K | A6NKB5 | protein_coding | tolerated(0.62) | benign(0.154) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCNX2 | SNV | Missense_Mutation | novel | c.3209N>G | p.Phe1070Cys | p.F1070C | A6NKB5 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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