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Gene: PC |
Gene summary for PC |
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Gene information | Species | Human | Gene symbol | PC | Gene ID | 5091 |
Gene name | pyruvate carboxylase | |
Gene Alias | PCB | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A024R5C5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5091 | PC | LZE4T | Human | Esophagus | ESCC | 1.99e-06 | 2.40e-01 | 0.0811 |
5091 | PC | LZE24T | Human | Esophagus | ESCC | 1.99e-06 | 8.82e-02 | 0.0596 |
5091 | PC | LZE21T | Human | Esophagus | ESCC | 2.38e-03 | 3.68e-01 | 0.0655 |
5091 | PC | P2T-E | Human | Esophagus | ESCC | 3.22e-06 | 6.93e-02 | 0.1177 |
5091 | PC | P4T-E | Human | Esophagus | ESCC | 1.05e-09 | 1.10e-01 | 0.1323 |
5091 | PC | P5T-E | Human | Esophagus | ESCC | 4.85e-02 | 4.69e-02 | 0.1327 |
5091 | PC | P8T-E | Human | Esophagus | ESCC | 4.74e-04 | 9.31e-02 | 0.0889 |
5091 | PC | P9T-E | Human | Esophagus | ESCC | 3.79e-14 | 2.80e-01 | 0.1131 |
5091 | PC | P10T-E | Human | Esophagus | ESCC | 1.41e-03 | 6.28e-02 | 0.116 |
5091 | PC | P11T-E | Human | Esophagus | ESCC | 3.75e-04 | 1.97e-01 | 0.1426 |
5091 | PC | P15T-E | Human | Esophagus | ESCC | 5.49e-28 | 6.82e-01 | 0.1149 |
5091 | PC | P16T-E | Human | Esophagus | ESCC | 6.55e-09 | 1.18e-01 | 0.1153 |
5091 | PC | P20T-E | Human | Esophagus | ESCC | 8.95e-07 | 1.32e-01 | 0.1124 |
5091 | PC | P21T-E | Human | Esophagus | ESCC | 3.28e-19 | 5.13e-01 | 0.1617 |
5091 | PC | P22T-E | Human | Esophagus | ESCC | 1.04e-02 | 3.64e-02 | 0.1236 |
5091 | PC | P23T-E | Human | Esophagus | ESCC | 3.45e-02 | 4.02e-02 | 0.108 |
5091 | PC | P24T-E | Human | Esophagus | ESCC | 7.89e-05 | 9.29e-02 | 0.1287 |
5091 | PC | P26T-E | Human | Esophagus | ESCC | 2.23e-03 | 2.30e-02 | 0.1276 |
5091 | PC | P27T-E | Human | Esophagus | ESCC | 1.89e-04 | 1.33e-01 | 0.1055 |
5091 | PC | P28T-E | Human | Esophagus | ESCC | 4.82e-06 | 1.58e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00457279 | Breast | Precancer | positive regulation of translation | 32/1080 | 136/18723 | 5.89e-12 | 9.27e-10 | 32 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00342509 | Breast | Precancer | positive regulation of cellular amide metabolic process | 33/1080 | 162/18723 | 1.72e-10 | 1.77e-08 | 33 |
GO:00621979 | Breast | Precancer | cellular response to chemical stress | 51/1080 | 337/18723 | 2.40e-10 | 2.34e-08 | 51 |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00345999 | Breast | Precancer | cellular response to oxidative stress | 42/1080 | 288/18723 | 2.78e-08 | 1.79e-06 | 42 |
GO:00104989 | Breast | Precancer | proteasomal protein catabolic process | 58/1080 | 490/18723 | 1.54e-07 | 8.05e-06 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0002014 | Esophagus | ESCC | Citrate cycle (TCA cycle) | 27/4205 | 30/8465 | 3.48e-06 | 1.94e-05 | 9.95e-06 | 27 |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0123023 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0062023 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa0002015 | Esophagus | ESCC | Citrate cycle (TCA cycle) | 27/4205 | 30/8465 | 3.48e-06 | 1.94e-05 | 9.95e-06 | 27 |
hsa0120033 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0123033 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0062033 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa0120010 | Liver | NAFLD | Carbon metabolism | 26/1043 | 115/8465 | 1.39e-03 | 1.71e-02 | 1.38e-02 | 26 |
hsa0120011 | Liver | NAFLD | Carbon metabolism | 26/1043 | 115/8465 | 1.39e-03 | 1.71e-02 | 1.38e-02 | 26 |
hsa0120021 | Liver | Cirrhotic | Carbon metabolism | 64/2530 | 115/8465 | 6.37e-09 | 1.18e-07 | 7.26e-08 | 64 |
hsa006208 | Liver | Cirrhotic | Pyruvate metabolism | 29/2530 | 47/8465 | 5.90e-06 | 5.95e-05 | 3.67e-05 | 29 |
hsa0002010 | Liver | Cirrhotic | Citrate cycle (TCA cycle) | 21/2530 | 30/8465 | 6.56e-06 | 6.24e-05 | 3.84e-05 | 21 |
hsa012304 | Liver | Cirrhotic | Biosynthesis of amino acids | 35/2530 | 75/8465 | 1.54e-03 | 7.83e-03 | 4.83e-03 | 35 |
hsa0120031 | Liver | Cirrhotic | Carbon metabolism | 64/2530 | 115/8465 | 6.37e-09 | 1.18e-07 | 7.26e-08 | 64 |
hsa0062011 | Liver | Cirrhotic | Pyruvate metabolism | 29/2530 | 47/8465 | 5.90e-06 | 5.95e-05 | 3.67e-05 | 29 |
hsa0002011 | Liver | Cirrhotic | Citrate cycle (TCA cycle) | 21/2530 | 30/8465 | 6.56e-06 | 6.24e-05 | 3.84e-05 | 21 |
hsa0123011 | Liver | Cirrhotic | Biosynthesis of amino acids | 35/2530 | 75/8465 | 1.54e-03 | 7.83e-03 | 4.83e-03 | 35 |
hsa0120041 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0002021 | Liver | HCC | Citrate cycle (TCA cycle) | 28/4020 | 30/8465 | 1.08e-07 | 1.44e-06 | 8.02e-07 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PC | SNV | Missense_Mutation | rs750387125 | c.365N>G | p.Ser122Cys | p.S122C | P11498 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-T2-A6WX-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
PC | SNV | Missense_Mutation | rs766679405 | c.1544C>T | p.Pro515Leu | p.P515L | P11498 | protein_coding | tolerated(0.15) | benign(0.088) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PC | SNV | Missense_Mutation | rs543756586 | c.2279N>A | p.Arg760Gln | p.R760Q | P11498 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PC | SNV | Missense_Mutation | rs780682688 | c.170N>T | p.Thr57Met | p.T57M | P11498 | protein_coding | deleterious(0.03) | probably_damaging(0.97) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PC | SNV | Missense_Mutation | rs780682688 | c.170N>T | p.Thr57Met | p.T57M | P11498 | protein_coding | deleterious(0.03) | probably_damaging(0.97) | TCGA-BR-8077-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PC | SNV | Missense_Mutation | c.3184N>A | p.Ala1062Thr | p.A1062T | P11498 | protein_coding | tolerated(0.09) | benign(0.031) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PC | SNV | Missense_Mutation | c.3061A>G | p.Lys1021Glu | p.K1021E | P11498 | protein_coding | tolerated(0.67) | benign(0.022) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PC | SNV | Missense_Mutation | c.307A>G | p.Ile103Val | p.I103V | P11498 | protein_coding | tolerated(0.17) | benign(0.3) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
PC | SNV | Missense_Mutation | c.2780N>A | p.Ser927Asn | p.S927N | P11498 | protein_coding | tolerated(0.19) | benign(0) | TCGA-CD-5801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
PC | SNV | Missense_Mutation | c.449G>T | p.Gly150Val | p.G150V | P11498 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5091 | PC | ENZYME, CLINICALLY ACTIONABLE | AMPHOTERICIN B | 2015823 | ||
5091 | PC | ENZYME, CLINICALLY ACTIONABLE | CORTISOL | HYDROCORTISONE | 942746 |
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