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Gene: NWD1 |
Gene summary for NWD1 |
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Gene information | Species | Human | Gene symbol | NWD1 | Gene ID | 284434 |
Gene name | NACHT and WD repeat domain containing 1 | |
Gene Alias | NWD1 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q149M9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284434 | NWD1 | HCC1 | Human | Liver | HCC | 7.03e-21 | 2.11e+00 | 0.5336 |
284434 | NWD1 | HCC2 | Human | Liver | HCC | 2.75e-38 | 2.24e+00 | 0.5341 |
284434 | NWD1 | HCC5 | Human | Liver | HCC | 4.48e-36 | 2.11e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510902 | Liver | HCC | regulation of DNA-binding transcription factor activity | 220/7958 | 440/18723 | 8.04e-04 | 4.82e-03 | 220 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NWD1 | SNV | Missense_Mutation | c.4279A>G | p.Ser1427Gly | p.S1427G | Q149M9 | protein_coding | tolerated(0.35) | benign(0.059) | TCGA-HP-A5N0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NWD1 | SNV | Missense_Mutation | rs758051323 | c.3815C>T | p.Thr1272Met | p.T1272M | Q149M9 | protein_coding | deleterious(0.03) | probably_damaging(0.917) | TCGA-KR-A7K0-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NWD1 | SNV | Missense_Mutation | c.3617N>T | p.Arg1206Leu | p.R1206L | Q149M9 | protein_coding | deleterious(0.02) | benign(0.272) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NWD1 | SNV | Missense_Mutation | novel | c.1606N>A | p.Leu536Met | p.L536M | Q149M9 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-55-7281-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
NWD1 | SNV | Missense_Mutation | novel | c.2222N>T | p.Arg741Leu | p.R741L | Q149M9 | protein_coding | tolerated(0.21) | benign(0.007) | TCGA-55-7281-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
NWD1 | SNV | Missense_Mutation | c.2837N>G | p.Phe946Cys | p.F946C | Q149M9 | protein_coding | deleterious(0) | possibly_damaging(0.655) | TCGA-64-1681-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
NWD1 | SNV | Missense_Mutation | c.895N>A | p.Arg299Ser | p.R299S | Q149M9 | protein_coding | tolerated(0.31) | possibly_damaging(0.668) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
NWD1 | SNV | Missense_Mutation | c.2669N>A | p.Gly890Asp | p.G890D | Q149M9 | protein_coding | deleterious(0.01) | possibly_damaging(0.656) | TCGA-78-7159-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NWD1 | SNV | Missense_Mutation | c.1012G>T | p.Val338Leu | p.V338L | Q149M9 | protein_coding | deleterious(0.03) | possibly_damaging(0.741) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NWD1 | SNV | Missense_Mutation | rs770074174 | c.3092N>T | p.Thr1031Met | p.T1031M | Q149M9 | protein_coding | tolerated(0.05) | benign(0.272) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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