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Gene: NFAT5 |
Gene summary for NFAT5 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NFAT5 | Gene ID | 10725 |
Gene name | nuclear factor of activated T cells 5 | |
Gene Alias | NF-AT5 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | O94916 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10725 | NFAT5 | CA_HPV_1 | Human | Cervix | CC | 5.90e-03 | -5.80e-03 | 0.0264 |
10725 | NFAT5 | CCI_1 | Human | Cervix | CC | 3.15e-05 | 9.17e-01 | 0.528 |
10725 | NFAT5 | CCI_2 | Human | Cervix | CC | 1.05e-08 | 1.40e+00 | 0.5249 |
10725 | NFAT5 | CCI_3 | Human | Cervix | CC | 4.64e-14 | 1.47e+00 | 0.516 |
10725 | NFAT5 | L1 | Human | Cervix | CC | 5.82e-04 | -3.11e-01 | 0.0802 |
10725 | NFAT5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.33e-04 | 5.34e-01 | -0.0811 |
10725 | NFAT5 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.61e-14 | 6.73e-01 | -0.1954 |
10725 | NFAT5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.27e-05 | 7.34e-01 | -0.059 |
10725 | NFAT5 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.36e-17 | 1.27e+00 | 0.3487 |
10725 | NFAT5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.09e-19 | 1.18e+00 | 0.281 |
10725 | NFAT5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.71e-08 | 1.00e+00 | 0.3859 |
10725 | NFAT5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.67e-11 | 8.55e-01 | 0.3005 |
10725 | NFAT5 | F007 | Human | Colorectum | FAP | 4.66e-03 | -2.79e-02 | 0.1176 |
10725 | NFAT5 | A002-C-010 | Human | Colorectum | FAP | 8.06e-03 | -3.46e-02 | 0.242 |
10725 | NFAT5 | A001-C-207 | Human | Colorectum | FAP | 1.39e-04 | -2.43e-01 | 0.1278 |
10725 | NFAT5 | A015-C-203 | Human | Colorectum | FAP | 3.07e-39 | -4.42e-01 | -0.1294 |
10725 | NFAT5 | A015-C-204 | Human | Colorectum | FAP | 6.85e-09 | -3.43e-01 | -0.0228 |
10725 | NFAT5 | A014-C-040 | Human | Colorectum | FAP | 6.92e-07 | -3.71e-01 | -0.1184 |
10725 | NFAT5 | A002-C-201 | Human | Colorectum | FAP | 2.62e-12 | -2.70e-01 | 0.0324 |
10725 | NFAT5 | A002-C-203 | Human | Colorectum | FAP | 3.78e-03 | -1.54e-01 | 0.2786 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
GO:00224099 | Cervix | CC | positive regulation of cell-cell adhesion | 61/2311 | 284/18723 | 9.30e-06 | 2.11e-04 | 61 |
GO:19030397 | Cervix | CC | positive regulation of leukocyte cell-cell adhesion | 53/2311 | 239/18723 | 1.37e-05 | 2.74e-04 | 53 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:00457852 | Colorectum | MSS | positive regulation of cell adhesion | 110/3467 | 437/18723 | 2.94e-04 | 3.87e-03 | 110 |
GO:00457853 | Colorectum | MSI-H | positive regulation of cell adhesion | 48/1319 | 437/18723 | 1.47e-03 | 2.23e-02 | 48 |
GO:00457854 | Colorectum | FAP | positive regulation of cell adhesion | 92/2622 | 437/18723 | 3.09e-05 | 7.04e-04 | 92 |
GO:00069701 | Colorectum | FAP | response to osmotic stress | 25/2622 | 84/18723 | 1.43e-04 | 2.24e-03 | 25 |
GO:0048016 | Colorectum | FAP | inositol phosphate-mediated signaling | 16/2622 | 55/18723 | 2.78e-03 | 2.15e-02 | 16 |
GO:00457855 | Colorectum | CRC | positive regulation of cell adhesion | 81/2078 | 437/18723 | 2.28e-06 | 1.10e-04 | 81 |
GO:0097720 | Colorectum | CRC | calcineurin-mediated signaling | 13/2078 | 48/18723 | 1.72e-03 | 1.77e-02 | 13 |
GO:0033173 | Colorectum | CRC | calcineurin-NFAT signaling cascade | 12/2078 | 43/18723 | 1.93e-03 | 1.96e-02 | 12 |
GO:00480161 | Colorectum | CRC | inositol phosphate-mediated signaling | 14/2078 | 55/18723 | 2.21e-03 | 2.15e-02 | 14 |
GO:0070884 | Colorectum | CRC | regulation of calcineurin-NFAT signaling cascade | 10/2078 | 34/18723 | 2.96e-03 | 2.66e-02 | 10 |
GO:0106056 | Colorectum | CRC | regulation of calcineurin-mediated signaling | 10/2078 | 35/18723 | 3.74e-03 | 3.14e-02 | 10 |
GO:0022407 | Colorectum | CRC | regulation of cell-cell adhesion | 67/2078 | 448/18723 | 6.86e-03 | 4.81e-02 | 67 |
GO:004578516 | Endometrium | AEH | positive regulation of cell adhesion | 96/2100 | 437/18723 | 5.50e-11 | 7.18e-09 | 96 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
NFAT5 | KER | Esophagus | HGIN | MALAT1,PARD6B,NEAT1, etc. | 2.81e-01 | |
NFAT5 | INMON | Lung | AAH | SAMSN1,SRGN,JARID2, etc. | 1.02e-01 |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFAT5 | SNV | Missense_Mutation | c.153N>T | p.Lys51Asn | p.K51N | O94916 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
NFAT5 | SNV | Missense_Mutation | c.3956N>G | p.Gln1319Arg | p.Q1319R | O94916 | protein_coding | deleterious(0) | possibly_damaging(0.549) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
NFAT5 | SNV | Missense_Mutation | c.3230N>T | p.Asn1077Ile | p.N1077I | O94916 | protein_coding | deleterious_low_confidence(0) | benign(0.091) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |
NFAT5 | SNV | Missense_Mutation | c.3664N>T | p.Pro1222Ser | p.P1222S | O94916 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
NFAT5 | deletion | Frame_Shift_Del | novel | c.3135delN | p.Ser1047ValfsTer2 | p.S1047Vfs*2 | O94916 | protein_coding | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NFAT5 | SNV | Missense_Mutation | novel | c.2014N>A | p.His672Asn | p.H672N | O94916 | protein_coding | tolerated(0.19) | probably_damaging(0.968) | TCGA-BJ-A191-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFAT5 | SNV | Missense_Mutation | c.4182N>T | p.Leu1394Phe | p.L1394F | O94916 | protein_coding | deleterious(0) | benign(0.055) | TCGA-EL-A3MZ-01 | Thyroid | thyroid carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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