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Gene: NDST3 |
Gene summary for NDST3 |
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Gene information | Species | Human | Gene symbol | NDST3 | Gene ID | 9348 |
Gene name | N-deacetylase and N-sulfotransferase 3 | |
Gene Alias | HSST3 | |
Cytomap | 4q26 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | O95803 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9348 | NDST3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.76e-04 | 3.30e-01 | -0.1088 |
9348 | NDST3 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.81e-10 | 3.80e-01 | -0.1954 |
9348 | NDST3 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.84e-09 | 3.69e-01 | -0.1464 |
9348 | NDST3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.80e-03 | 1.66e-01 | -0.1001 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDST3 | SNV | Missense_Mutation | novel | c.1342N>T | p.Ser448Cys | p.S448C | O95803 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NDST3 | SNV | Missense_Mutation | novel | c.1230N>A | p.His410Gln | p.H410Q | O95803 | protein_coding | tolerated(0.05) | benign(0.419) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDST3 | SNV | Missense_Mutation | c.1951N>A | p.Asp651Asn | p.D651N | O95803 | protein_coding | tolerated(0.35) | possibly_damaging(0.673) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NDST3 | SNV | Missense_Mutation | novel | c.2363N>A | p.Gly788Glu | p.G788E | O95803 | protein_coding | tolerated(0.12) | probably_damaging(0.936) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
NDST3 | SNV | Missense_Mutation | rs772285048 | c.565N>A | p.Ala189Thr | p.A189T | O95803 | protein_coding | tolerated(0.23) | possibly_damaging(0.45) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NDST3 | SNV | Missense_Mutation | novel | c.1300C>A | p.Leu434Ile | p.L434I | O95803 | protein_coding | deleterious(0) | possibly_damaging(0.708) | TCGA-63-A5ML-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | vinorelbine | SD |
NDST3 | SNV | Missense_Mutation | novel | c.2072T>A | p.Ile691Asn | p.I691N | O95803 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
NDST3 | SNV | Missense_Mutation | novel | c.1253N>G | p.Tyr418Cys | p.Y418C | O95803 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
NDST3 | SNV | Missense_Mutation | novel | c.1230N>G | p.His410Gln | p.H410Q | O95803 | protein_coding | tolerated(0.05) | benign(0.419) | TCGA-NC-A5HI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
NDST3 | SNV | Missense_Mutation | rs775212321 | c.2257N>A | p.Glu753Lys | p.E753K | O95803 | protein_coding | deleterious(0.02) | benign(0.111) | TCGA-BB-8596-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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