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Gene: MUC17 |
Gene summary for MUC17 |
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Gene information | Species | Human | Gene symbol | MUC17 | Gene ID | 140453 |
Gene name | mucin 17, cell surface associated | |
Gene Alias | MUC-17 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q685J3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140453 | MUC17 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.48e-06 | 1.16e+00 | -0.1808 |
140453 | MUC17 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.03e-05 | 4.70e-01 | -0.0811 |
140453 | MUC17 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.93e-04 | 2.05e+00 | -0.2602 |
140453 | MUC17 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.40e-05 | 1.44e+00 | -0.2196 |
140453 | MUC17 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.12e-02 | -1.38e-01 | 0.0674 |
140453 | MUC17 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.38e-03 | -1.42e-01 | 0.3859 |
140453 | MUC17 | A015-C-203 | Human | Colorectum | FAP | 2.05e-02 | -1.36e-01 | -0.1294 |
140453 | MUC17 | A002-C-201 | Human | Colorectum | FAP | 1.71e-02 | -1.46e-01 | 0.0324 |
140453 | MUC17 | A002-C-203 | Human | Colorectum | FAP | 7.57e-03 | -1.37e-01 | 0.2786 |
140453 | MUC17 | A001-C-108 | Human | Colorectum | FAP | 1.92e-04 | -1.40e-01 | -0.0272 |
140453 | MUC17 | A015-C-106 | Human | Colorectum | FAP | 3.19e-04 | -1.20e-01 | -0.0511 |
140453 | MUC17 | A015-C-202 | Human | Colorectum | FAP | 1.83e-02 | -1.46e-01 | -0.0849 |
140453 | MUC17 | A001-C-203 | Human | Colorectum | FAP | 3.34e-02 | -1.31e-01 | -0.0481 |
140453 | MUC17 | A002-C-116 | Human | Colorectum | FAP | 2.00e-05 | -1.39e-01 | -0.0452 |
140453 | MUC17 | F034 | Human | Colorectum | FAP | 4.21e-02 | -1.31e-01 | -0.0665 |
140453 | MUC17 | CRC-3-11773 | Human | Colorectum | CRC | 2.60e-02 | -1.15e-01 | 0.2564 |
140453 | MUC17 | Pat01-B | Human | Stomach | GC | 5.32e-84 | 1.37e+00 | 0.5754 |
140453 | MUC17 | Pat02-B | Human | Stomach | GC | 1.54e-25 | 5.48e-01 | 0.0368 |
140453 | MUC17 | Pat03-B | Human | Stomach | GC | 1.41e-42 | 1.00e+00 | 0.3693 |
140453 | MUC17 | Pat05-B | Human | Stomach | GC | 6.46e-04 | 2.62e-01 | -0.0353 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC17 | SNV | Missense_Mutation | c.11560T>A | p.Ser3854Thr | p.S3854T | Q685J3 | protein_coding | tolerated(0.08) | benign(0.099) | TCGA-A6-6782-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC17 | SNV | Missense_Mutation | c.3256G>T | p.Ala1086Ser | p.A1086S | Q685J3 | protein_coding | tolerated(0.14) | benign(0.062) | TCGA-AA-3696-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
MUC17 | SNV | Missense_Mutation | c.3821N>C | p.Ser1274Thr | p.S1274T | Q685J3 | protein_coding | deleterious(0.03) | benign(0.092) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC17 | SNV | Missense_Mutation | novel | c.8605N>G | p.Thr2869Ala | p.T2869A | Q685J3 | protein_coding | deleterious(0) | possibly_damaging(0.636) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MUC17 | SNV | Missense_Mutation | rs771685225 | c.5807C>G | p.Thr1936Arg | p.T1936R | Q685J3 | protein_coding | deleterious(0) | possibly_damaging(0.484) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MUC17 | SNV | Missense_Mutation | c.7024N>T | p.Arg2342Cys | p.R2342C | Q685J3 | protein_coding | deleterious(0.01) | benign(0.046) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC17 | SNV | Missense_Mutation | rs567129894 | c.439G>A | p.Val147Met | p.V147M | Q685J3 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MUC17 | SNV | Missense_Mutation | c.6959C>A | p.Pro2320His | p.P2320H | Q685J3 | protein_coding | deleterious(0) | benign(0.089) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MUC17 | SNV | Missense_Mutation | novel | c.3905C>A | p.Pro1302His | p.P1302H | Q685J3 | protein_coding | deleterious(0) | benign(0.437) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MUC17 | SNV | Missense_Mutation | novel | c.9697C>T | p.Pro3233Ser | p.P3233S | Q685J3 | protein_coding | tolerated(0.36) | benign(0.441) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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