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Gene: MROH1 |
Gene summary for MROH1 |
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Gene information | Species | Human | Gene symbol | MROH1 | Gene ID | 727957 |
Gene name | maestro heat like repeat family member 1 | |
Gene Alias | HEATR7A | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | B4DIR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
727957 | MROH1 | LZE4T | Human | Esophagus | ESCC | 6.84e-04 | 1.38e-01 | 0.0811 |
727957 | MROH1 | LZE7T | Human | Esophagus | ESCC | 5.88e-06 | 2.56e-01 | 0.0667 |
727957 | MROH1 | LZE8T | Human | Esophagus | ESCC | 9.46e-06 | 1.33e-01 | 0.067 |
727957 | MROH1 | LZE20T | Human | Esophagus | ESCC | 6.78e-08 | 2.26e-01 | 0.0662 |
727957 | MROH1 | LZE24T | Human | Esophagus | ESCC | 3.80e-11 | 1.81e-01 | 0.0596 |
727957 | MROH1 | P1T-E | Human | Esophagus | ESCC | 1.55e-09 | 3.53e-01 | 0.0875 |
727957 | MROH1 | P2T-E | Human | Esophagus | ESCC | 9.57e-14 | 1.33e-01 | 0.1177 |
727957 | MROH1 | P4T-E | Human | Esophagus | ESCC | 6.99e-08 | 1.18e-01 | 0.1323 |
727957 | MROH1 | P5T-E | Human | Esophagus | ESCC | 3.41e-10 | 1.86e-01 | 0.1327 |
727957 | MROH1 | P8T-E | Human | Esophagus | ESCC | 2.30e-09 | 1.12e-01 | 0.0889 |
727957 | MROH1 | P9T-E | Human | Esophagus | ESCC | 3.35e-05 | 1.37e-01 | 0.1131 |
727957 | MROH1 | P10T-E | Human | Esophagus | ESCC | 9.41e-12 | 1.49e-01 | 0.116 |
727957 | MROH1 | P11T-E | Human | Esophagus | ESCC | 1.55e-03 | 1.77e-01 | 0.1426 |
727957 | MROH1 | P12T-E | Human | Esophagus | ESCC | 5.62e-11 | 1.76e-01 | 0.1122 |
727957 | MROH1 | P15T-E | Human | Esophagus | ESCC | 1.30e-11 | 2.34e-01 | 0.1149 |
727957 | MROH1 | P16T-E | Human | Esophagus | ESCC | 6.60e-17 | 2.33e-01 | 0.1153 |
727957 | MROH1 | P17T-E | Human | Esophagus | ESCC | 3.82e-04 | 2.24e-01 | 0.1278 |
727957 | MROH1 | P20T-E | Human | Esophagus | ESCC | 1.74e-04 | 1.08e-01 | 0.1124 |
727957 | MROH1 | P21T-E | Human | Esophagus | ESCC | 1.50e-19 | 4.42e-01 | 0.1617 |
727957 | MROH1 | P22T-E | Human | Esophagus | ESCC | 3.12e-17 | 1.04e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MROH1 | SNV | Missense_Mutation | novel | c.338T>C | p.Val113Ala | p.V113A | Q8NDA8 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MROH1 | SNV | Missense_Mutation | novel | c.3433A>G | p.Thr1145Ala | p.T1145A | Q8NDA8 | protein_coding | tolerated(0.17) | benign(0.108) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MROH1 | SNV | Missense_Mutation | novel | c.4330C>T | p.Arg1444Cys | p.R1444C | Q8NDA8 | protein_coding | deleterious(0) | possibly_damaging(0.63) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MROH1 | insertion | In_Frame_Ins | novel | c.1662_1663insGGACGTGTG | p.Arg556_Gly557insValGlyArg | p.R556_G557insVGR | Q8NDA8 | protein_coding | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MROH1 | deletion | Frame_Shift_Del | novel | c.1159delN | p.Lys388SerfsTer8 | p.K388Sfs*8 | Q8NDA8 | protein_coding | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MROH1 | deletion | Frame_Shift_Del | novel | c.1368delN | p.Lys458ArgfsTer23 | p.K458Rfs*23 | Q8NDA8 | protein_coding | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MROH1 | SNV | Missense_Mutation | c.194N>G | p.Val65Gly | p.V65G | Q8NDA8 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-DD-A4NQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
MROH1 | SNV | Missense_Mutation | novel | c.3446G>C | p.Trp1149Ser | p.W1149S | Q8NDA8 | protein_coding | deleterious(0.05) | probably_damaging(0.991) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
MROH1 | SNV | Missense_Mutation | novel | c.1342G>A | p.Glu448Lys | p.E448K | Q8NDA8 | protein_coding | tolerated(0.94) | benign(0) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MROH1 | SNV | Missense_Mutation | novel | c.2255C>T | p.Pro752Leu | p.P752L | Q8NDA8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-95-A4VK-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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