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Gene: MLLT10 |
Gene summary for MLLT10 |
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Gene information | Species | Human | Gene symbol | MLLT10 | Gene ID | 8028 |
Gene name | MLLT10 histone lysine methyltransferase DOT1L cofactor | |
Gene Alias | AF10 | |
Cytomap | 10p12.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P55197 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8028 | MLLT10 | CCI_1 | Human | Cervix | CC | 8.14e-04 | 7.06e-01 | 0.528 |
8028 | MLLT10 | CCI_2 | Human | Cervix | CC | 6.09e-08 | 8.99e-01 | 0.5249 |
8028 | MLLT10 | CCI_3 | Human | Cervix | CC | 1.95e-11 | 9.49e-01 | 0.516 |
8028 | MLLT10 | EEC-subject2 | Human | Endometrium | EEC | 7.74e-04 | 2.38e-01 | -0.2607 |
8028 | MLLT10 | EEC-subject3 | Human | Endometrium | EEC | 5.77e-06 | -9.15e-02 | -0.2525 |
8028 | MLLT10 | EEC-subject4 | Human | Endometrium | EEC | 2.99e-03 | 1.19e-01 | -0.2571 |
8028 | MLLT10 | GSM5276934 | Human | Endometrium | EEC | 5.18e-07 | -1.58e-01 | -0.0913 |
8028 | MLLT10 | GSM5276937 | Human | Endometrium | EEC | 9.73e-04 | -1.81e-01 | -0.0897 |
8028 | MLLT10 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.71e-10 | -8.75e-02 | -0.1869 |
8028 | MLLT10 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.18e-06 | -8.94e-02 | -0.1875 |
8028 | MLLT10 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.23e-13 | -1.22e-01 | -0.1883 |
8028 | MLLT10 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.15e-07 | 1.19e-02 | -0.1934 |
8028 | MLLT10 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.13e-14 | -1.51e-01 | -0.1917 |
8028 | MLLT10 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.80e-13 | -1.03e-01 | -0.1916 |
8028 | MLLT10 | LZE4T | Human | Esophagus | ESCC | 1.06e-11 | 4.74e-01 | 0.0811 |
8028 | MLLT10 | LZE7T | Human | Esophagus | ESCC | 2.42e-04 | 1.81e-01 | 0.0667 |
8028 | MLLT10 | LZE8T | Human | Esophagus | ESCC | 4.26e-05 | 1.83e-01 | 0.067 |
8028 | MLLT10 | LZE24T | Human | Esophagus | ESCC | 3.08e-18 | 5.56e-01 | 0.0596 |
8028 | MLLT10 | P1T-E | Human | Esophagus | ESCC | 1.19e-08 | 4.97e-01 | 0.0875 |
8028 | MLLT10 | P2T-E | Human | Esophagus | ESCC | 7.98e-24 | 4.51e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MLLT10 | SNV | Missense_Mutation | c.2359G>A | p.Ala787Thr | p.A787T | P55197 | protein_coding | tolerated(0.83) | benign(0) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MLLT10 | SNV | Missense_Mutation | c.614N>C | p.Lys205Thr | p.K205T | P55197 | protein_coding | deleterious(0.02) | possibly_damaging(0.906) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MLLT10 | SNV | Missense_Mutation | rs369695121 | c.1322N>A | p.Gly441Asp | p.G441D | P55197 | protein_coding | tolerated(0.06) | benign(0.203) | TCGA-D7-6526-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
MLLT10 | SNV | Missense_Mutation | c.1771N>A | p.Val591Ile | p.V591I | P55197 | protein_coding | tolerated(0.14) | probably_damaging(0.956) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |
MLLT10 | SNV | Missense_Mutation | novel | c.551G>T | p.Gly184Val | p.G184V | P55197 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
MLLT10 | SNV | Missense_Mutation | novel | c.277N>G | p.Lys93Glu | p.K93E | P55197 | protein_coding | deleterious(0.01) | probably_damaging(0.928) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
MLLT10 | SNV | Missense_Mutation | novel | c.29T>C | p.Leu10Pro | p.L10P | P55197 | protein_coding | tolerated(0.06) | benign(0.202) | TCGA-VQ-A925-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MLLT10 | insertion | Frame_Shift_Ins | novel | c.2288dupA | p.Asn763LysfsTer28 | p.N763Kfs*28 | P55197 | protein_coding | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
MLLT10 | insertion | Frame_Shift_Ins | rs747811015 | c.1224_1225insG | p.Val411GlyfsTer3 | p.V411Gfs*3 | P55197 | protein_coding | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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